SUMMARY This paper presents analysis and design of a new ultra-low voltage analog front end (AFE) dedicated to strain sensor applications. The AFE, designed in 0.18 μm CMOS process, features a chopper-stabilized instrumentation amplifier (IA), a balanced active MOSFET-C 2nd order low pass filter (LPF), a clock generator and a voltage booster which operate at supply voltage (Vdd) of 0.6 V. The designed IA achieves 30 dB of closedloop gain, 101 dB of common-mode rejection ratio (CMRR) at 50 Hz, 80 dB of power-supply rejection ratio (PSRR) at 50 Hz, thermal noise floor of 53.4 nV/ √ Hz, current consumption of 14 μA, and noise efficiency factor (NEF) of 9.7. The high CMRR and rail-to-rail output swing capability is attributed to a new low voltage realization of the active-bootstrapped technique using a pseudo-differential gain-boosting operational transconductance amplifier (OTA) and proposed current-driven bulk (CDB) biasing technique. An output capacitor-less low-dropout regulator (LDO), with a new fast start-up LPF technique, is used to regulate this 0.6 V supply from a 0.8–1.0 V energy harvesting power source. It achieves power supply rejection (PSR) of 42 dB at frequency of 1 MHz. A cascode compensated pseudo differential amplifier is used as the filter’s building block for low power design. The filter’s single-ended-to-balanced converter is implemented using a new low voltage amplifier with two-stage common-mode cancellation. The overall AFE was simulated to have 65.6 dB of signalto-noise ratio (SNR), total harmonic distortion (THD) of less than 0.9% for a 100 Hz sinusoidal maximum input signal, bandwidth of 2 kHz, and power consumption of 51.2 μW. Spectre RF simulations were performed to validate the design using BSIM3V3 transistor models provided by GLOBALFOUNDRIES 0.18 μm CMOS process.