Orbital Expansion Research Articles

Helium roaming in excess electrons in C60F60 as dynamic quasi-Matryoshka dolls.

Multi-guest clathrates exhibit lots of functional characteristics owing to their unique structures, which herald beautiful application prospects, but their fundamental information is still scarce. Herein, we explore a type of (helium, excess electrons/EEs)-C60F60 co-clathrates with quasi-Matryoshka-doll structures using abinitio molecular dynamics simulation and reveal the EEs-entangled He roaming dynamics in C60F60 and its effect on the characteristics of clathrates. Perfluorination ensures that C60F60 possesses an extremely electropositive interior cavity. Its unique confinement effect can stabilize He as an extremely inert entity by noticeably enlarging the 1s-2s orbital gap and can also trap 1-2 EEs in its s-type interior orbital with extremely large binding energies. Co-inclusion of He and EEs in C60F60 exhibits inter-repulsive He⋯EEs entangling dynamics featuring quasi-Matryoshka-doll structures (He@EEs@C60F60). In this structure, EEs screen the attraction of cage-shell Cδ+ to He 1s2 electrons, thus inhibiting their stabilization and orbital expansion, while He conversely decreases the stability of EEs and redshifts their transition absorption. He can roam in the cavity, but its trajectory is impacted by EEs serving as a medium, and thus, the structures exhibit anormal dynamic variation of internuclear He⋯C spin coupling JHeC, which is manipulated by the EEs-entangled He roaming dynamics. JHeC and JHeC' present opposite distance dependences for the colinearly aligned C⋅⋅⋅He⋅⋅⊗⋅⋅⋅⋅⋅C' (⊗, the cage center). This work provides insights into the Matryoshka-doll structured He@EEs@C60F60 with He-EEs entangling dynamics and its modulation on EEs absorption and reveals the dynamic role of EEs in manipulating He-roaming and JHeC coupling properties for promising applications.

Positron interactions with vinyl acetate from 0.1 eV to 5 keV

Abstract Scattering cross sections from positron impact on vinyl acetate are explored in the energy region 0.1~eV to a 5~keV, employing a cc-pVTZ basis set. The optimized molecular wavefunction of the target was obtained through a multi-center expansion of Gaussian-type orbitals in the Hartree-Fock self-consistent field framework. The elastic cross sections are computed using the single-centre-expansion formalism. Two distinct models were employed to address the long-range effects associated with the target's polar nature and yielded almost identical corrections. The Born-corrected elastic cross sections align more strongly with the existing experimental corrected data than the results reported from the independent-atom-model approximation. The differential and momentum transfer cross sections after applying Born-correction are also reported. The direct ionization cross sections are obtained using the binary-encounter-Bethe model for positrons. The cross sections obtained by summing elastic and ionization cross sections align closely with `forward angle corrected' experimental total cross sections across a significant energy range. The agreement significantly improves beyond 30 eV, suggesting that the omission of excitation and positronium formation cross sections becomes less significant. A brief analysis of the electron interaction with the target is also made.

6822 Proptosis Improvement with Teprotumumab is Independent of Race, Ethnicity, Gender and Age from Three Global Randomized, Double-Masked, Placebo-Controlled Trials of Patients with Acute Thyroid Eye Disease (TED)

Abstract Disclosure: G.J. Kahaly: Consulting Fee; Self; Amgen Inc. Research Investigator; Self; Amgen Inc. S.T. Wester: Advisory Board Member; Self; Amgen Inc. Consulting Fee; Self; Immunovant, Lassen. Research Investigator; Self; Amgen Inc, Sling Therapeutics, Immunovant. C.Y. Liu: Other; Self; royalties from Wolters Kluwers Health. H. Kate: Employee; Self; Amgen Inc. Stock Owner; Self; Amgen Inc. E. Conrad: Employee; Self; Amgen Inc. Stock Owner; Self; Amgen Inc. R.J. Holt: Employee; Self; Amgen Inc. Stock Owner; Self; Amgen Inc. Y. Hiromatsu: Advisory Board Member; Self; Amgen Inc. Consulting Fee; Self; Amgen Inc. Research Investigator; Self; Amgen Inc. Introduction: Thyroid eye disease (TED) produces orbital tissue expansion, inflammation, proptosis (eye bulging) and diplopia (double vision), causing eye pain and appearance/visual changes. Teprotumumab, an insulin-like growth factor-1 receptor inhibitor, significantly improved signs and symptoms of TED in three placebo-controlled trials in patients with high inflammation. Here, we report pooled proptosis response in patient subgroups. Methods: Patients ≥18 years old from three placebo-controlled trials, two in the US and EU (NCT01868997, NCT03298867) and one in Japan (OPTIC-J; jRCT2031210453), with Graves’ disease and recent onset (≤9 month duration) active TED (Clinical activity score, CAS≥4, ≥3 for OPTIC-J) were included. Patients received eight infusions of teprotumumab or placebo over 21 weeks, with the final study visit at Week 24 (three weeks after final dose). Observed proptosis response, defined as ≥2 mm improvement from baseline in study eye without deterioration ≥2 mm in fellow eye at Week 24, versus placebo is reported by tobacco use (yes/no), race (White or Asian), and age (<65/≥65). Cochran-Mantel-Haenszel tests compared teprotumumab and placebo subgroups. Results: Of 111 teprotumumab and 114 placebo patients, 68.5% (76) and 76.3% (87) were female, respectively; mean (SD) age 50.3 (12.4) and 51.1 (13.1) years, respectively; mean (SD) TED duration 5.49 (2.32) and 5.98 (2.40) months, respectively; and 78.4% (87) and 73.7% (84) were never/former smokers, respectively. In the overall population, 80.2% (89/111) of teprotumumab patients and 14.0% (16/114) of placebo patients had a proptosis response (P<.0001). At Week 24, 70.8% (17/24) of teprotumumab and 23.3% (7/30) placebo smokers were proptosis responders; in non-smokers, 82.8% (72/87) of teprotumumab and 10.7% (9/84) placebo patients were proptosis responders (P<.0001 for both). In White patients, 78.9% (56/71) of teprotumumab and 15.8% (12/76) of placebo patients were proptosis responders; in Asian patients, 90.0% (27/30) of teprotumumab and 10.0% (3/30) of placebo patients were responders (P<.0001 for both). In patients <65 years, 79.2% (76/96) teprotumumab patients and 13.4% (13/97) placebo patients were responders; in patients ≥65 years, 86.7% (13/15) teprotumumab and 17.6% (3/17) placebo were responders (P<.0001 for both). Conclusions: Subgroup analysis of proptosis response by tobacco use, race, and age showed that teprotumumab treatment led to significantly higher proptosis response versus placebo in all groups. Public Presentation: 6/1/2024

Signatures of circumbinary disc dynamics in multimessenger population studies of massive black hole binaries

ABSTRACT We investigate the effect of the cutting-edge circumbinary disc (CBD) evolution models on massive black hole binary (MBHB) populations and the gravitational wave background (GWB). We show that CBD-driven evolution leaves a tell-tale signature in MBHB populations, by driving binaries towards an equilibrium eccentricity that depends on the binary mass ratio. We find high orbital eccentricities ($e_{\rm b} \sim 0.5$) as MBHBs enter multimessenger observable frequency bands. The CBD-induced eccentricity distribution of MBHB populations in observable bands is independent of the initial eccentricity distribution at binary formation, erasing any memory of eccentricities induced in the large-scale dynamics of merging galaxies. Our results suggest that eccentric MBHBs are the rule rather than the exception in upcoming transient surveys, provided that CBDs regularly form in MBHB systems. We show that the GWB amplitude is sensitive to CBD-driven preferential accretion onto the secondary, resulting in an increase in GWB amplitude $A_{\rm yr^{-1}}$ by over 100 per cent with just 10 per cent Eddington accretion. As we self-consistently allow for binary hardening and softening, we show that CBD-driven orbital expansion does not diminish the GWB amplitude, and instead increases the amplitude by a small amount. We further present detection rates and population statistics of MBHBs with $M_{\rm b} \gtrsim 10^6 \, {\rm M}_{\odot }$ in Laser Interferometer Space Antenna, showing that most binaries have equal mass ratios and can retain residual eccentricities up to $e_{\rm b} \sim 10^{-3}$ due to CBD-driven evolution.

Study of Earth’s Obliquity Evolutionary History by Advanced Kinematic Model

NASA’s press release of ‘Moon having receded by 1 m from Earth in a quarter of century’ on the Silver Jubilee Anniversary (20 July 1994) of Man’s landing on Moon led to the development of the Kinematic Model (KM) of evolving Earth-Moon System (E-M system). Best fit KM parameters is adopted for the analysis of evolving E-M system assuming the present length of day of Earth to be 24 hours, sidereal orbital period of Moon divided by spin period of Earth = LOM(length of month)/LOD(length of day) = 27.322 and the age of Moon=4.467Gy. Using the best fit model parameters the velocity of recession of Moon is derived as 2.3cm/y as compared to 3.7cm/y by Lunar Laser Ranging experiment (Dickey et.al. 1994) [1]. Matija Cuk et.al (2016) have proposed a new model for the birth and tidal evolution of our natural satellite Moon born from impact generated terrestrial debris in the equatorial plane of high obliquity, high angular momentum Earth [2]. Using Moon’s orbital plane inclination angle (α), Moon’s obliquity (β) and eccentricity(e) of Moon’s orbit around Earth the advanced KM was developed and used for predicting the evolutionary history of Earth’s obliquity from a (semimajor axis of Moon) = 45RE = 2.96695×108 m (Cassini State Transition orbit) to the present a = 60.336RE = 3.844×108 m [3]. The present paper is sequel to the paper Sharma (2024) [5]. In the Advanced KM. (Φ)-Earth’s obliquity, (α)-Lunar orbital plane inclination, (β)-Lunar Obliquity and (e)-eccentricity of Moon’s orbit around Earth have been included. It has been shown that with the present epoch value of Φ = 23.4°, α = 5.14° , β = 1.54° and e = 0.0549, the general equation describing the evolution of E-M system from 45RE=2.96695×108 m to the present a = 60.336RE = 3.844×108 m yields (Length of Month/Length of Day) = 27.32 with fine tuning of globe-orbit parameters within its measurement error margin. But the tension between the predicted and the observed velocity of recession could not be removed even in the Advanced KM. This tension constrains Moon to be in an accelerated expanding spiral orbit where it recedes from 3.274×108 m to the present orbit 3.844×108 m in 1.2Gy time span. In the classical model this spiral expansion took 1.9Gy where it monotonically expanded spirally from 18,000Km to 384,440Km.. In the new hypothesis according to Cuk et.al. of Moon’s origin from high obliquity, high angular momentum Earth, Moon initially spirals out in chaotic manner with the lunar expansion getting stalled at Laplace Plane Transition as well as in Cassini State transition [2]. Plus in multiple-impact scenario of Moon formation according to Rufu et.al. also results in a delayed formation of full size Moon [4]. Both these factors result in a longer transit time from 18,000Km to 3.012×108 m of 3.267Gy. This results in an accelerated phase from 3.012×108 m to 3.844×108 m in 1.2Gy subsequently resulting into radial recession rate of 3.7cm/y. In the Advanced KM, 3.267Gy is spent in spiral orbital expansion from 3RE to 45RE but in fits and 1.2Gy is spent in accelerated monotonic spiral expansion from 45RE to 60.336RE. Hence this model is called fits and bound model. This also results in a much better match between observed LOD curve and theoretical LOD curve as is shown in a sequel paper [5]. In the present paper Advanced Kinematic Model analyzes the history of the evolution of Earth’s Obliqquity from the birth of Moon 4.467Gy ago to the present modern times.

Unveiling Modern Strategies for Diagnosing and Treating Grave Orbitopathy

Graves' Orbitopathy (GO), also known as thyroid eye disease or thyroid-associated orbitopathy is characterized by inflammation, ocular muscle hypertrophy, adipogenesis, and oedema (due to glycosaminoglycan accumulation). This condition leads to remodeling, tissue expansion, and/or fibrosis within the fibroadipose tissue or extraocular muscles of the orbit. GO manifests as an extrathyroidal aspect of autoimmune thyroid diseases in both Grave's disease (GD) and Hashimoto's thyroiditis.
 The pathophysiological foundation of GO entails the infiltration of B cells, T cells, and CD34+ fibroblasts in the orbit. B cells generate IGF (insulin-like growth factor), wherein IGF and TRab (Thyroid-Receptor antibodies) stimulate the IGF receptor complex and thyrotropin receptor (respectively) on the surface of CD34+ cells which triggers orbital tissue expansion, orbital protrusion, optic nerve compression, and eyeball displacement, resulting in exophthalmos.
 GO progress through an active phase (characterized by inflammation with visible manifestations), followed by a plateau phase (stabilization of GO manifestations), and a gradual resolution of distinctive residual signs and symptoms (inactive phase). This entire process spans between 18-24 months in untreated patients, where disease manifestations significantly depend on the phase during which the disease is identified.
 GO therapy is intended to shorten the active phase and supress its residual eye manifestations during the inactive phase. In general, GO therapy is categorized into general and disease severity-specific approaches.
 GO therapy often falls short of providing satisfactory results, prompting need of surgery to address lingering clinical manifestations. This review presents the latest insights into the pathogenesis and treatment of GO for better management and outcomes.

Gravitational wave mergers of accreting binary black holes in AGN discs

ABSTRACT Binary black hole (BBH) evolution in the discs of active galactic nuclei (AGNs) is a promising channel for gravitational wave (GW)-driven mergers. It is, however, unclear whether binaries interacting with the surrounding disc undergo orbital contraction or expansion. We develop a simple analytical model of accreting BBHs in AGN discs to follow the orbital evolution from the disc-dominated regime at large separations into the GW-driven regime at small separations (the coupled ‘disc + GW’-driven evolution). We obtain that accreting binaries expand in thick discs with aspect ratio greater than a critical value (>hcrit); whereas accreting binaries contract and eventually merge in thin discs (<hcrit). Interestingly, accreting BBHs can experience faster mergers compared to non-accreting counterparts, with a non-monotonic dependence on the disc aspect ratio. The orbital contraction is usually coupled with eccentricity growth in the disc-dominated regime, which lead to accelerated inspirals in the GW-driven regime. We quantify the resulting BBH merger time-scales in AGN discs (τmerger ∼ 105–107 yr) and estimate the associated GW merger rates ($\mathcal {R} \sim (0.2 {\small --} 5) \, \text{Gpc}^{-3} \text{yr}^{-1}$). Overall, accreting binaries may efficiently contract and merge in thin discs, hence this particular BBH-in-AGN channel may provide a non-negligible contribution to the observed GW merger event rate.

Theoretical study on molecular charge populations of 1D π-stacked multimers in neutral and electron oxidation states

Abstract We theoretically investigated molecular charge populations of 1D π-stacked multimers consisting of π-conjugated molecules in the neutral and electron oxidation states based on the valence-bond (VB) theory. Qualitative analysis for a π-stacked trimer model based on the VB mixing diagram suggested that the inner monomer site tends to be more positively charged than the outer sites in the monocationic π-stacked trimer. Spatial expansion of each molecular site orbital toward the stacking direction is predicted to enhance the difference of positive charge populations between the inner and outer monomers. In contrast, an opposite tendency for the site charges was expected in the dicationic π-stacked trimer, primarily due to the hole–hole Coulomb repulsions. To generalize the results of the trimer to π-stacked N-mers, 1D N-site VB configuration interaction models were constructed considering the orbital expansion effects between the sites. We examined how the number of monomers (N), stacking distance (R), and characteristic orbital exponent for the monomers (ζ) affected the molecular charge populations in the monocationic and dicationic π-stacked N-mers through the parameters χij characterizing the orbital expansion effect. The results are expected to help establish design strategies for novel electronic functional materials based on discrete stacks of π-conjugated molecules.

Anomalous orbital expansion of the low-mass X-ray binary 2A 1822-371: the existence of a circumbinary disk?

Source 2A 1822-371 is an eclipsing low-mass X-ray binary (LMXB) consisting of a neutron star (NS) and a ∼0.5 M⊙donor star in an orbit of 5.57 h. Based on the timing of the eclipse arrival times, this source was found to experience a rapid orbital expansion with an orbital period derivative asṖorb= (1.51 ± 0.05) × 10−10s s−1, implying that the mass-transfer rate is probably higher than at least three times the Eddington accretion rate. The standard magnetic braking (MB) model cannot produce a mass-transfer rate this high. The modified MB model can produce a high mass-transfer rate, resulting in a highṖorb. We propose an alternative model to account for the anomalously high mass-transfer rate andṖorbof 2A 1822-371. During the mass transfer, a tiny fraction of the transferred material is thought to form a circumbinary (CB) disk around the LMXB, which can efficiently extract orbital angular momentum from the system by the interaction between the CB disk and the binary. We used the MESA code to model the formation and evolution of 2A 1822-371 for different CB-disk masses. When the CB-disk mass is 2.3 × 10−8 M⊙, the simulation can reproduce the observed donor-star mass, orbital period, and orbital period derivative. This CB disk can accelerate the evolution of the binary and produce a high mass-transfer rate of 1.9 × 10−7M⊙yr−1, driving the binary to evolve toward a wide-orbit system. Therefore, we propose that CB disks may cause the rapid orbital changes observed in some LMXBs.

Orbital expansion variational quantum eigensolver

Variational quantum eigensolver (VQE) has emerged as a promising method for investigating ground state properties in quantum chemistry, materials science, and condensed matter physics. However, the conventional VQE method generally lacks systematic improvement and convergence guarantees, particularly when dealing with strongly correlated systems. In light of these challenges, we present a novel framework called orbital expansion VQE (OE-VQE) to address these limitations. The key idea is to devise an efficient convergence path by utilizing shallower quantum circuits, starting from a highly compact active space and gradually expanding it until convergence to the ground state is achieved. To validate the effectiveness of the OE-VQE framework, we conducted benchmark simulations on several small yet representative molecules, including the chain, ring and . The simulation results demonstrate that our proposed convergence paths significantly enhance the performance of conventional VQE. Overall, our work sheds valuable insight into the simulation of molecules based on shallow quantum circuits, offering a promising avenue for advancing the efficiency and accuracy of VQE approaches in tackling complex molecular systems.

The Impact of Orbital Volume on Post-traumatic Enophthalmos: A Systematic Review and Meta-analysis.

Orbital volume increase has been previously linked with post-traumatic enophthalmos. However, this varies and some studies show no correlation. This systematic review and meta-analysis aimed to synthesize the correlation between orbital volume and enophthalmos and to determine if surgical intervention, enophthalmos measurement method, fracture location, or timing affect this correlation. Automation tools were used to assist in this review of 6 databases. Searches were performed across all dates. Included studies quantitatively reported orbital volume and enophthalmos following traumatic orbital wall fractures in at least 5 adult subjects. Correlational data were extracted or calculated. Random-effects meta-analysis was used with subgroup analyses for each of the secondary aims. Twenty-five articles describing 648 patients were included. The pooled correlation between orbital volume and enophthalmos was r =0.71 ( R2 =0.50, P <0.001). Operative status, enophthalmos measurement method, and fracture location did not affect pooled correlation. The delay between trauma or surgery and enophthalmos measurement was not shown to modulate correlation for unoperated patients ( R2 =0.05, P =0.22) but showed a negative relationship for postoperative patients ( z =-0.0281, SE=0.0128, R2 =0.63, P =0.03), but this was heavily influenced by a single article. All results had high residual heterogeneity. Studies were rated as moderate, low, or very low quality with few stating explicit hypotheses or limitations. Bony orbital volume expansion accounts for around 50% of post-traumatic enophthalmos. The other half is probably explained by soft tissue or geometric bony, rather than volumetric, changes.

Vectorial Doppler complex spectrum and its application to the rotational detection

Based on vectorial polarized fields of light applied to detect the rotational velocity by the rotational Doppler effect, we propose a method to measure the magnitude and direction of the rotational velocity simultaneously for a general rotating surface. When the rotational surface is rough, the scattered vectorial Doppler signal spectrum is complex. In this paper, we make complex spectrum analyses using the orbital angular momentum modal expansion method and measure the rotational velocity in the experiment.

Excimer Energies.

A multistate energy decomposition analysis (MS-EDA) method is introduced for excimers using density functional theory. Although EDA has been widely applied to intermolecular interactions in the ground state, few methods are currently available for excited-state complexes. Here, the total energy of an excimer state is separated into exciton excitation energy ΔEEx(|ΨX·ΨY⟩*), resulting from the state interaction between locally excited monomer states |ΨX*·ΨY⟩ and |ΨX·ΨY*⟩ , a superexchange stabilization energy ΔESE, originating from the mutual charge transfer between two monomers |ΨX+·ΨY⟩ and |ΨX-·ΨY+⟩ , and an orbital-and-configuration delocalization term ΔEOCD due to the expansion of configuration space and block-localized orbitals to the fully delocalized dimer system. Although there is no net charge transfer in symmetric excimer cases, the resonance of charge-transfer states is critical to stabilizing the excimer. The monomer localized excited and charge-transfer states are variationally optimized, forming a minimal active space for nonorthogonal state interaction (NOSI) calculations in multistate density functional theory to yield the intermediate states for energy analysis. The present MS-EDA method focuses on properties unique to excited states, providing insights into exciton coupling, superexchange and delocalization energies. MS-EDA is illustrated on the acetone and pentacene excimer systems; three configurations of the latter case are examined, including the optimized excimer, a stacked configuration of two pentacene molecules and the fishbone orientation. It is found that excited-state energy splitting is strongly dependent on the relative energies of the monomer excited states and the phase-matching of the monomer wave functions.

Differential cross sections for projectile scattering angle in proton-helium collision at intermediate energies

The collisions between proton and helium are treated with a semi-classical atomic orbital expansion for proton incident energies 5–150 keV considering two-electrons explicitly. Differential cross sections with respect to the projectile scattering angle are calculated for elastic scattering, 21S and 21P excitation, single electron capture, and single ionization. The agreement with experiments are mostly good, but non-negligible discrepancies are seen for the elastic scattering and the single electron capture with target excitation.

Spectrum of ocular manifestations in apert syndrome

Apert syndrome is a congenital type 1 acrocephalosyndactyly characterized by craniosynostosis, dysmorphic facial features and symmetrical syndactyly. There is premature fusion of cranial sutures which leads to restriction of intracranial and orbital space expansion giving characteristic dysmorphic facial appearance. We are reporting two cases of Apert syndrome of different age groups from ophthalmic point of view, and with different sets of ocular manifestation. Of the two cases, the one who presented early had a better visual prognosis. Apert Syndrome has a social stigma and the patients often suffers social and psychological disturbances. Patient counselling, timely management by multidisciplinary approach and regular follow ups are an important aspect which can offer a better quality of life.

Unravelling the evolution of hot Jupiter systems under the effect of tidal and magnetic interactions and mass-loss

ABSTRACT Various interactions affect the population of close-in planets. Among them, the tidal and magnetic interactions drive orbital decay and star-planet angular momentum exchange, leading to stellar spin-up. As a result of the above processes, a planet may initiate the mass transfer to the host star once it encounters the Roche limit. Another mechanism providing substantial mass-loss is associated with the atmospheric escape caused by photoevaporation followed by orbital expansion, which is thought to be important for hot Neptunes and super-Earths. Thus, the fraction of the initial number of hot Jupiters may transform into lower-mass planets through the Roche lobe overflow (RLO) phase and continue secular evolution under the effect of photoevaporation. In this paper, we compile the latest prescriptions for tidal and magnetic migration and mass-loss rates to explore the dynamics of hot Jupiter systems. We study how the implemented interactions shape the orbital architecture of Jovian planets and whether their impact is enough to reproduce the observational sample. Our models suggest that the tidal interaction is able to generate the upper boundary of the hot Jupiter population in the mass–separation diagram. To recreate the sub-Jovian desert, we need to make additional assumptions regarding the RLO phase or the influence of the protoplanetary disc’s inner edge on the initial planetary location. According to our estimates, 12–15 per cent of hot Jupiters around solar-mass stars have been engulfed or become lower-mass planets. 0.20–0.25 per cent of the present-day giant planet population undergoes decay intense enough to be detected with modern facilities.

Variability in Future Atmospheric Circulation Patterns in the MPI-ESM1-2-HR Model in Iran

Analyzing and classifying atmospheric circulation patterns (CPs) is useful for studying climate variability. These classifications can effectively identify the links between large-scale and regional-local scale processes. This work uses the historical (1975–2014) and projected (2015–2054) simulations of the MPI-ESM1-2-HR model to reproduce the CPs over the Middle East and Iran. Eighteen CPs were identified based on the geopotential height (GPH) of 500 hPa data from Coupled Model Intercomparison Project Phase 6 (CMIP6) in SSP1-2.6, SSP3-7.0, and SSP5-8.5. The method of principal component analysis (PCA) and k-means clustering was used. Then, the possible variability of each pattern in the surface and mid-level of the atmosphere and their expected changes in the frequency of CPs in global warming scenarios were investigated. This research showed that CPs 3, 6, and 11 happen during warm months of the year. The surface thermal low pressure is associated with the subtropical high in the atmosphere mid-level. According to the intensity of the low and the northward development, or the orbital expansion of the subtropical high, this pattern has an increasing (CPs 3 and 6) or decreasing (CP11) trend in the future period. CPs 1 and 12 occur during cold months. In CP1, dynamic high pressure prevails over Iran. However, in CP12, Iran is affected by high pressure from southeastern Europe. They will decrease in future projections. CPs 7 and 16, which often occur in the transition season (spring), show an increase in the projected patterns. CP 18 occurs throughout the year, but its highest frequency is in autumn, and the frequency of occurrence decreases. An increase in 500 hPa geopotential height over the Arabian Sea in all 18 classes and all three SSPs is predicted for future periods. Analysis of the obtained weather types indicates the identification of all effective atmospheric circulation patterns in the study area so that the behavior and frequency of each pattern explain the prevailing atmospheric phenomena in this region.

Enlargement of the Eye Socket Early after Birth with an Ocular Prosthesis for Clinical Congenital Anophthalmia

Clinical congenital anophthalmia causes facial asymmetry and difficulty in wearing ocular prostheses due to underdevelopment of the orbits. Orbital expansion must be started early after birth for treatment, but consensus regarding the treatment for clinical congenital anophthalmia has not been established. We report a successful orbital expansion using a thermoplastic splint. A one-month-old boy had left clinical congenital anophthalmia (ophthalmatrophia), right congenital glaucoma, and right anterior segment ocular dysgenesis. Two months after birth, left orbital expansion was initiated using a custom-made thermoplastic splint. The splint was replaced with larger ones in steps as the infant grew, and the orbit was successfully expanded. There is no appreciable size difference between the left and right orbit after 5 years of follow up. Treatment using a splint for the conjunctival sac is a simple and effective procedure that can be performed on an outpatient basis. Safer and simpler material should be widely used for the treatment.

Modeling Hartree-Fock approximations of the Schrödinger Equation for multielectron atoms from Helium to Xenon using STO-nG basis sets

The energy of an atom is extremely useful in nuclear physics and reaction mechanism pathway determination but is challenging to compute. Thus, we aimed to synthesize regression models for Pople Gaussian expansions of Slater-type Orbitals (STO-nG) atomic energy vs. atomic number scatter plots to allow for easy approximation of atomic energies without using computational chemistry methods. Using the Hartree-Fock method, we calculated atomic energies for elements helium to xenon (He to Xe) using STO-nG electron orbital basis set models. After calculating atomic energies for each basis set, we plotted them as tables of atomic energy (in Hartrees) versus the atomic number. We hypothesized that there would be a non-linear correlation in the scatter plot. We first formed the regressions using data from helium to krypton (He to Kr), and then we added new data from Kr to Xe. We then calculated the old and new coefficients of determination, and the difference between them. Due to their common use in modeling, exponential, sinusoidal, and quadratic regressions were tested to model the data. The data supported the hypothesis that the scatter plots had non-linear correlations. Sinusoidal and quadratic regressions had higher initial coefficients, suggesting higher viability, while sinusoidal regressions also had the highest average final coefficients, and the lowest change in coefficients. The data indicated that of the three regressions, sinusoidal regressions most aptly modeled the scatter plots.

Glucocorticoids Directly Affect Hyaluronan Production of Orbital Fibroblasts; A Potential Pleiotropic Effect in Graves' Orbitopathy.

Orbital connective tissue expansion is a hallmark of Graves’ orbitopathy (GO). In moderate-to-severe active GO, glucocorticoids (GC) are the first line of treatment. Here we show that hydrocortisone (HC), prednisolone (P), methylprednisolone (MP), and dexamethasone (DEX) inhibit the hyaluronan (HA) production of orbital (OF) and dermal (DF) fibroblasts. HA production of GO OFs (n = 4), NON-GO OFs (n = 4) and DFs (n = 4) was measured by ELISA. mRNA expression of enzymes of HA metabolism and fibroblast proliferation was examined by RT-PCR and BrdU incorporation, respectively. After 24 h of GC treatment (1µM) HA production decreased by an average of 67.9 ± 3.11% (p < 0.0001) in all cell cultures. HAS2, HAS3 and HYAL1 expression in OFs also decreased (p = 0.009, p = 0.0005 and p = 0.015, respectively). Ten ng/mL PDGF-BB increased HA production and fibroblast proliferation in all cell lines (p < 0.0001); GC treatment remained effective and reduced HA production under PDGF-BB-stimulated conditions (p < 0.0001). MP and DEX reduced (p < 0.001, p = 0.002, respectively) PDGF-BB-induced HAS2 expression in OFs. MP and DEX treatment decreased PDGF-BB stimulated HAS3 expression (p = 0.035 and p = 0.029, respectively). None of the GCs tested reduced the PDGF-BB stimulated proliferation rate. Our results confirm that GCs directly reduce the HA production of OFs, which may contribute to the beneficial effect of GCs in GO.