Orbital Aspergillosis Research Articles

Ophthalmic Plastic & Reconstructive Surgery
Sep 1, 1993
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Orbital Aspergillosis: Conservative Debridement and Local Amphotericin Irrigation

A patient maintained on long-term immunosuppressive agents after bone marrow transplantation developed an Aspergillus abscess in the right orbit. The abscess was resected without visual compromise and the orbit was irrigated regularly with amphotericin B via an indwelling catheter. Follow-up computed tomography, surgical exploration, and histological analysis demonstrated suppression of fungal growth in the orbit. Persistent fungus was recovered from nonirrigated sinuses despite their previous surgical evacuation and continued systemic amphotericin B administration. Treatment of orbital aspergillosis should include surgical reduction of the local fungal inoculum, supplementation of intravenous antifungal agents with local delivery to minimize systemic toxicity, and attempts to reverse the immunosuppression. If the last is not possible, extensive extirpation of normal surrounding tissues will not prevent repopulation by the ubiquitous fungus.

Ophthalmic Plastic & Reconstructive Surgery
Sep 1, 1989
Gerald J Harris + 1

Orbital aspergillosis producing an orbital apex syndrome and enophthalmos

An atypical presentation of orbital aspergillosis producing an orbital apex syndrome and enophthalmos is described. the most frequent presentation of orbital aspergillosis is proptosis and associated sinus disease.

Orbit
Jan 1, 1988
Mark L Malton + 1

Orbital Aspergillosis

SUMMARY We treated a 40-year-old male who had orbital aspergillosis and presumed early intracranial extension with limited orbital exenteration and adjunctive amphotericin B. Forty-two months later the patient is alive without recurrence. Our patient illustrates the typical presentation of orbital aspergillosis with severe periorbital pain and proptosis; however, he did not have the usual concomitant sinusitis. Aggressive surgical and antifungal therapy in this case was successful in preventing further intracranial extension, which usually has a high mortality rate.

Ophthalmic Surgery, Lasers and Imaging Retina
Mar 1, 1983
Richard K Dortzbach + 1

Parasellar and orbital apex syndrome caused by aspergillosis

Patients with orbital aspergillosis commonly present with unilateral proptosis and associated sinus disease. However, neither of these manifestations was observed in a 62-year-old woman who had an orbital apex syndrome with visual loss, complete ophthalmoplegia, and corneal hypoesthesia. Pathologic examination of specimen from a granulomalike mass removed at left frontotemporal craniotomy showed branching hyphae with the characteristic appearance of Aspergillus.

Neurology
Feb 1, 1976
Thomas R Hedges + 1

Asperillosis of the orbit. Report of ten cases and review of the literature.

Half of ten cases of orbital aspergillosis occurred in patients in the fourth and fifth decades of life. In four cases, the orbit was secondarily involved, probably from direct extension from the paranasal sinuses. Of five patients who had brain involvement, the primary focus of infection in two was apparently intracranial, while in three there was secondary involvement of the central nervous system. No evidence of systemic fungal disease was found. The disease presented a protracted clinical course with poor response to local excision of involved tissues and antifungal agents. Six patients are known to have died of the disease; the other four were lost to follow-up. Species ofAspergilluswas cultured in four cases. A review of the literature disclosed only 20 previously reported cases.