Oral Tinidazole Research Articles

A placebo-controlled, double-blind comparison of tinidazole and triple sulfonamide cream for the treatment of nonspecific vaginitis

Oral tinidazole, 500 mg twice daily for 5 days, was compared to triple sulfonamide cream inserted into the vagina twice daily for 7 days for the treatment of nonspecific vaginitis in a placebo-controlled, double-blind trial. At 1 and 3 weeks after treatment, 29 of 30 and 18 of 19 patients, respectively, who had been given tinidazole were cured, as compared to 16 of 27 and 6 of 14 patients, respectively, who had been given oral placebo together with a vaginal cream with or without sulfonamides (p < 0.01 and p = 0.0015, respectively). At 3 weeks, five of nine women who had received vaginal sulfonamide cream and oral placebo had persistent nonspecific vaginitis, thus suggesting that it was not more effective than a vaginal placebo cream. Untreated nonspecific vaginitis and persistence of this syndrome were significantly associated with Gardnerella vaginalis, anaerobic gram-negative rods, clue cells, a vaginal pH of ≥5.0, a succinate/lactate peak heights ratio of ≥0.3, and the absence of lactobacilli on a vaginal smear.

Prophylactic oral and intravenous tinidazole in hysterectomy.

Prophylactic oral and intravenous tinidazole in hysterectomy.

Tinidazole: a review of clinical experience in anaerobic infections.

Oral and intravenous tinidazole have been evaluated in an extensive series of clinical trials for the treatment of anaerobic infections and for the prevention of infection after gastrointestinal and gynaecological surgery. In almost all studies simple dosage regimens were used; these were based on the pharmacokinetic properties of tinidazole and its in-vitro activity against almost all clinically relevant anaerobic bacteria. These characteristics permit the use of single pre-operative dpse in surgical prophylaxis and once daily dosage in treatment. Results in the therapy of proven and strongly suspected anaerobic infections in approximately 264 patients are summarized. Patients received tinidazole alone or together with an agent active against aerobes, usually an aminoglycoside. Very good efficacy and an almost complete freedom from significant side effects were observed in patients treated for a wide variety of anaerobic infections. These included septicaemia. upper respiratory infections and sinusitis, anginose infectious mononucleosis, broncho-pulmonary infections, osteomyelitis. pelvic infections. septic abortion, peritonitis and post-operative intra-abdominal sepsis, cellulitis and post-operative wound infection. Chemotherapy was often associated with surgical drainage. Findings with intravenous or oral tinidazole for the prophylaxis of post-operative infections after gastrointestinal and gynaecological surgery are reviewed. Almost all studies involved comparison with another drug regimen, double-blind comparison with placebo or the inclusion of a control group. Although tinidazole alone was used in most trials, an agent active against aerobic bacteria was included in some. A significant reduction in the incidence of infection after colorectal surgery, general abdominal surgery and gynaecological surgery (especially vaginal hysterectomy) was found in all studies. In addition, the prophylactic use of tinidazole was shown in several studies to cause a marked reduction in post-operative antibiotic usage and a shorter hospital stay. Few side effects were reported.