objective: Oral pathologies have repercussions on the correct performance of activities of daily living and consequently on well-being and quality of life, particularly in subjects with disabilities. The aim of this study was to assess the oral health-related quality of life in physically disabled children attending the education and rehabilitation center for physically disabled children “Talibou Dabo Centre” in Dakar.materials and methods: A cross-sectional study of disabled children aged 8 to 14 attending the “Talibou Dabo” Center was carried out. A clinical oral examination was carried out, followed by an assessment of oral health-related quality of life using the Child Perception Questionnaire (CPQ8-14ans). results: A total of 48 children aged 8 to 14 with a mean age of 10.43 years ±1,809 were included. The prevalence of caries was 56.25% and the mean mixed DMF was 2.4±2.7. Plaque control was good in 6.25% of children. Most children (89.6%) had bleeding on probing. The mean CPQ was 15.8±8.4 with a median of 11. Oral symptoms were infrequent (CPQ=3,73), as well as functional limitation (CPQ=3,36), emotional well-being was moderately affected (CPQ=5,52) and social well-being was minimally affected (CPQ=3,19). There was no correlation between oral health, disability and quality of life.Conclusion: The mean CPQ score for all domains combined was low, indicating that disability has no impact on oral health-related quality of life in this category of the population.