A 52-year-old white male patient, non-smoker and non-drinker, was diagnosed with adenoid cystic carcinoma, stage pTN0M0, treated with left subtotal maxillectomy. The treatment consisted of surgery applied to the maxillary bone, followed by radiotherapy, performing 30 fractions of 200cGy. The patient presented a disease recurrence in the sphenoid bone, which was treated with a new cycle of SBRT CP 4/5 × 80cGy radiotherapy. The patient was followed up by dental care during radiotherapy for preventive photobiomodulation of oral mucositis. Afterwards, oral rehabilitation was completed. Upon physical oral examination, the patient presented all teeth in the mandible and partial tooth loss in the maxilla due to the surgical approach. A 5-centimeter bone defect was observed, comprising both the soft and hard palate, and a resin prosthetic device covered the bone defect. In conclusion, our approach promoted occlusal restoration, improving both esthetics and functional speech. A 52-year-old white male patient, non-smoker and non-drinker, was diagnosed with adenoid cystic carcinoma, stage pTN0M0, treated with left subtotal maxillectomy. The treatment consisted of surgery applied to the maxillary bone, followed by radiotherapy, performing 30 fractions of 200cGy. The patient presented a disease recurrence in the sphenoid bone, which was treated with a new cycle of SBRT CP 4/5 × 80cGy radiotherapy. The patient was followed up by dental care during radiotherapy for preventive photobiomodulation of oral mucositis. Afterwards, oral rehabilitation was completed. Upon physical oral examination, the patient presented all teeth in the mandible and partial tooth loss in the maxilla due to the surgical approach. A 5-centimeter bone defect was observed, comprising both the soft and hard palate, and a resin prosthetic device covered the bone defect. In conclusion, our approach promoted occlusal restoration, improving both esthetics and functional speech.