Oral Naming Research Articles

The brief executive language screen: sensitivity and specificity in acute to early sub-acute stroke

ABSTRACT Introduction Propositional language and underlying executive functions can be impaired post-stroke and affect communication and quality of life. Current stroke screening tools are largely tailored to patients with aphasia, being either non-verbal or focussed on core language skills such as naming and repetition. The Brief Executive Language Screening Test (BELS) is a newly developed cognitive screening tool that assesses memory, oral apraxia, core language, as well as propositional language and associated executive functions that can be impacted and overlooked in stroke patients without aphasia. This study examines BELS sensitivity and specificity, and performance in acute to early sub-acute stroke relative to controls. Method Cross-sectional BELS data from 88 acute left and right hemisphere stroke patients (within 7 weeks of stroke) and 116 age-matched healthy controls were compared using independent samples t-tests. ROC Curve Analysis was performed to determine a cutoff score for the BELS. Results Left and right stroke patients were reduced on all propositional language subtests, and executive function subtests of inhibition, strategy, and selection. Differences were also observed for Oral Apraxia, Naming, and Memory. By contrast, Word Comprehension and Repetition, and Sentence Completion Initiation (after corrections applied) did not differ between groups. A total BELS score of 79.25/100 was highly sensitive (.89) and specific (.89) when classifying stroke patients and healthy controls. Conclusion The BELS is brief, sensitive, suitable for bedside administration, and can aid in detection and rehabilitation of subtle executive language impairments. This in turn will help improve relationships and quality of life post-stroke.

Improving lexical retrieval with LingoTalk: an app-based, self-administered treatment for clients with aphasia

IntroductionLingoTalk is a German speech-language app designed to enhance lexical retrieval in individuals with aphasia. It incorporates automatic speech recognition (ASR) to provide therapist-independent feedback. The execution and effectiveness of a self-administered intervention with LingoTalk was explored in a case series study.MethodsThree individuals with chronic aphasia participated in a highly individualized, supervised self-administered intervention lasting 3 weeks. The LingoTalk app closely monitored the frequency, intensity and progress of the intervention. Treatment efficacy was assessed using a multiple baseline design, examining both item-specific treatment effects and generalization to untreated items, an untreated task, and spontaneous speech.ResultsAll participants successfully completed the intervention with LingoTalk, although one participant was not able to use the ASR feature. None of the participants fully adhered to the treatment protocol. All participants demonstrated significant and sustained improvement in the naming of practiced items, although there was limited evidence of generalization. Additionally, there was a slight reduction in word-finding difficulties during spontaneous speech.DiscussionThis small-scale study indicates that self-administered intervention with LingoTalk can improve oral naming of treated items. Thus, it has the potential to complement face-to-face speech-language therapy, such as within in a “flipped speech room” approach. The choice of feedback mode is discussed. Transparent progress monitoring of the intervention appears to positively influence patients' motivation.

Comparison of Oral and Written Confrontation Naming In Typical Bilingual Young and Middle Aged Adults

Comparison of Oral and Written Confrontation Naming In Typical Bilingual Young and Middle Aged Adults

Tumor region associated with specific processing speed outcomes.

Processing speed (PS) is a vulnerable cognitive skill in pediatric cancer survivors as a consequence of treatments and, less consistently, tumor region. Studies conventionally examine graphomotor PS; emerging research suggests other aspects of PS may be impacted. This study examined types of PS in pediatric brain tumor survivors to determine which aspects are impaired. Given discordance across studies, we additionally investigated the relationship between brain region and PS. The sample consisted of 167 pediatric brain tumor patients (100 supratentorial). PS (oral naming, semantic fluency, phonemic fluency, motor speed, graphomotor speed, visual scanning) was gathered via clinical neuropsychological assessment. To examine PS by region, infratentorial and supratentorial groups were matched on age at diagnosis and neuropsychological assessment, and time since diagnosis. The whole sample performed below normative means on measures of oral naming (p<.001), phonemic fluency (p<.001), motor speed (p=.03), visual scanning (p<.001), and graphomotor speed (p<.001). Only oral naming differed by region (p=.03), with infratentorial tumors associated with slower performance. After controlling for known medical and demographic risk factors, brain region remained a significant predictor of performance (p=.04). Among the whole sample, greater than expected proportions of patients with impairment (i.e.,>1 standard deviation below the normative mean) were seen across all PS measures. Infratentorial tumors had higher rates of impairments across all PS measures except phonemic fluency. Results indicate pediatric brain tumor survivors demonstrate weaknesses in multiple aspects of PS, suggesting impairments are not secondary to peripheral motor slowing alone. Additionally, tumor region may predict some but not all neuropsychological outcomes in this population.

Neuropsychiatric symptoms influence differently cognitive decline in older women and men

ObjectiveThe potential impact of sex on cognitive performance in normal aging and participants with Alzheimer's disease (AD) has been outlined previously. Nevertheless, differences in neuropsychiatric symptoms (NPS) have been also outlined. We aimed to study a potential association between NPS and cognitive performances according to sex, in older individuals with and without cognitive impairment. MethodsDemographic, neuropsychiatric and neuropsychological data from the ADNI and NACC databases were merged into a dataset of 506 participants with healthy cognitive performance, 467 patients with mild cognitive impairment, and 238 patients with AD. Cognitive performance in each group was evaluated according to sex and the presence of NPS. ResultsBased on sex, cognitive performance differed according to clinical stage: in the healthy controls and AD groups, women had better fluency performance, while in the mild cognitive impairment group, women had better working memory and men better oral naming. Regardless of sex, depression showed a negative effect on processing speed in AD. Finally, there was an interaction between sex and NPS in mild cognitive impairment, where women with apathy had better working memory performance, and in AD, women with depression had better fluency performance. The opposite pattern being was observed in men, where men with depression have worse focused attention. ConclusionCognitive performance is influenced by sex, yet this influence has different manifestations at normal cognition, MCI or AD. Furthermore, apathy and depression seem to influence differently women and men at different types of cognitive decline.

Prevalence and prospective evaluation of cognitive dysfunctions after SARS due to SARS-CoV-2 virus. The COgnitiVID study

ObjectiveCOVID-19 due to SARS-CoV-2 virus is a new cause of severe acute respiratory syndrome (SARS). Little is known about the short-term cognitive prognosis for these patients. We prospectively evaluated basic cognitive functions shortly after care in the intensive care unit (ICU) and three months later in post-ICU COVID-19 patients. Material and methodsWe performed a prospective single-center study in our institution in Paris. Patients with SARS-CoV-2 SARS were prospectively recruited via our ICU. Patients were evaluated using standardized cognitive tests at baseline and at three months’ follow-up. Our primary endpoint was the evolution of the following five global tests: MMSE, FAB, oral naming test, Dubois five words test and MADRS. ResultsWe explored 13 patients at baseline and follow-up. All patients had cognitive impairment at baseline but they all improved at three months, significantly on two of the five global tests after Bonferroni correction for multiple testing: MMSE (median 18 (IQR [15–22]) and 27 (IQR [27–29]) respectively, P=0.002) and FAB test (median 14 (IQR [14–17]) and 17 (IQR [17,18]) respectively, P=0.002). ConclusionsWe report here the first longitudinal data on short-term cognitive impairment after intensive care in COVID-19 patients. We found acute and short-term cognitive impairment but significant improvement at three months. This pattern does not seem to differ from other causes of post-intensive care syndrome.

Primary CNS lymphoma of the corpus callosum: presentation and neurocognitive outcomes.

The corpus callosum (CC) is frequently involved in primary central nervous system lymphomas (PCNSLs). In this cohort study, we described the neurocognition of patients with PCNSL-CC and its posttherapeutic evolution. Immunocompetent patients with PCNSL-CC were identified retrospectively at the Pitié-Salpêtrière Hospital. We described their clinical presentation. Neuropsychological test scores (MMSE; digit spans; Free and Cued Selective Reminding Test; Image Oral Naming Test; Frontal Assessment Battery; Trail Making Test; Stroop and verbal fluency tests; Rey's Complex Figure test) and factors impacting them were analyzed. Twenty-seven patients were included (median age: 67years, median Karnofsky Performance Status: 70); cognitive impairment and balance disorders were present in 74% and 59%, respectively. At diagnosis, neuropsychological test results were abnormal for global cognitive efficiency (63% of patients), memory (33-80% depending on the test) and executive functions (44-100%). Results for visuospatial and language tests were normal. All patients received high-dose methotrexate-based polychemotherapy, followed in one patient by whole-brain radiotherapy; 67% of patients achieved complete response (CR). With a median follow-up of 48months (range 6-156), patients in CR had persistent abnormal test results for global cognitive efficiency in 17%, executive function in 18-60%, depending on the test, and memory in 40-60%. Splenium location and age ≥ 60years were significantly associated with worse episodic memory scores throughout the follow-up. PCNSL-CC is associated with frequent cognitive dysfunctions, especially memory impairment, which may recover only partially despite CR and warrant specific rehabilitation. Older age (≥ 60) and splenium location are associated with worse neurocognitive outcomes.

Noninvasive stimulation of the unlesioned hemisphere and phonological treatment in a case of chronic anomia post-stroke

ABSTRACT Chronic lexical anomia after left hemisphere (LH) stroke improves under personalized phonological treatment (PT). Cortical linking between language and hand motor areas (hand_M1) questioned whether PT-related improvement relies on the unlesioned hemisphere (UH) plasticity when LH is dysfunctional. Our 70-yo-woman case study showed that 10 sessions of excitatory stimulation of UH_hand-M1 combined with PT hastened oral picture naming improvement as compared to sham+PT and changes were maintained together with changes of untrained items andcorticomotor excitability increase. This supports a role of stimulation-induced plasticity of UH_hand M1 in language recovery, at least in the improvement of lexical anomia in chronic stroke.

Avaliação da linguagem em cirurgia de craniotomia com paciente acordado: relato de caso

ABSTRACT The purpose of this report is to describe the case of a patient who underwent awake craniotomy for neurosurgical resection of a glioma and pre, intra and postoperative linguistic assessment. Male patient, 27 years old, incomplete higher education presenting vomiting, mental confusion and tonic-clonic seizures. After the evaluation of the patient by the team and due preoperative guidance, the proposal of excision of the lesion while awake was clarified and accepted. At the start of the procedure, the fields were adjusted to keep the airway and eyes accessible for mapping with electrical stimulation and intraoperative language assessment. Due to the location of the tumor close to the speech motor area, tasks were proposed for the assessment of language in four moments: preoperative, intraoperative, immediate postoperative and mediate postoperative. The language skills tested in the four assessments were: comprehension and expression of oral language, linguistic transposition, associative language, naming, visual discrimination, fluency and syntax organization. In order to control and eliminate the learning effect of testing, the same tasks were requested, but with different contents for testing skills in the four phases. Surgery with the patient awake allowed the complete and safe resection of the tumor, without motor or linguistic damage to the patient. Team engagement, interdisciplinary interaction and detailed surgical planning constitute the pillar for the good result of such a complex and delicate procedure

Improvement in language function in patients with aphasia using computer-assisted executive function training: A controlled clinical trial.

Nonverbal cognitive training for aphasia has gained popularity. Prior research has found that cognitive status correlates with language function. To determine whether nonverbal computer-assisted executive control training (CAET) to improve cognitive status affects language performance in patients with aphasia (PWA) and executive dysfunction. A single blind randomized trial. Department of Rehabilitation, Affiliated Hospital of Xuzhou Medical University. A total of 68 individuals were randomized, underwent treatment and were included in the analysis (CAET group, n = 33; control group, n = 35). The experimental group was treated with 4 weeks of traditional speech and language therapy (SLT) combined with CAET. The control group underwent SLT only. Western Aphasia Battery [WAB]) with executive dysfunction (as assessed by the verbal fluency test [VFT], the Proverbs Test, the Tower of London Test [TLT], the Stroop Color and Word Test [SCWT], and the Trail Making Test [TMT]). Differences between pre- and posttreatment language outcomes except oral naming (group × time, p=.236) were significantly greater in the experimental group compared with the control group: spontaneous speech (group × time, p=.026), auditory comprehension (group × time, p < .001), speech repetition (group × time, p=.001), and aphasia quotient (AQ; group × time, p < .001). A similar effect was observed for cognitive function such as Trial Making Test (TMT)-A (group × time, p=.006), TMT-B (group × time, p=.005), and verbal fluency test (VFT-V; group × time, p=.018). The study demonstrates that CAET combined with SLT can yield favorable language outcomes for PWA, especially improvements in auditory comprehension and AQ. CAET combined with SLT generates benefits in both cognitive function and language performance.

Do gestures have a hand in verb retrieval? Investigation of iconic and non-iconic gestures in aphasia

ABSTRACT Background According to the lexical retrieval hypothesis (LRH), the primary function of gestures is to facilitate word retrieval. Thus, individuals with aphasia (IWA) might benefit from gestures in case of word retrieval impairments. However, the facilitative effect of gestures on word finding is still unclear since most facilitation/treatment studies combined gesture with linguistic cues. The LRH claims that the semantic content of a gesture is decisive for a facilitation effect on word retrieval. However, it remains unclear if and how IWA can perform adequate iconic gestures, especially in the presence of hemiparesis or limb apraxia. Thus, in the present study, we systematically studied the effect of iconic and non-iconic gesture production on oral verb naming in IWA and analysed the iconicity of gestures produced by IWA and healthy controls. Aims In the present study, we aimed (1) to investigate the potential facilitation effect of iconic and non-iconic gestures on verb retrieval in IWA and (2) to examine the IWA’s ability to produce adequate iconic gestures. Methods & Procedures Six IWA with impairments in naming verbs arising from a phonological, a lexical-semantic, or a combined deficit participated in a multiple single-case study targeting oral verb production. In the first experiment, IWA were asked to name pictures and to simultaneously perform either a relevant iconic gesture, a non-iconic gesture, or no gesture at all. In the second experiment, the video-recorded gestures produced during verb naming in the iconic gesture condition were rated for iconicity and compared to the iconicity of iconic gestures produced by 12 language-unimpaired controls. Results The accuracy in oral naming of verbs (Experiment 1) did not differ significantly between all conditions. Most IWA (n = 5) were able to produce iconic gestures, irrespective of hemiparesis or limb apraxia, since the iconicity ratings did not differ significantly from language-unimpaired controls (Experiment 2). Conclusions In contrast to the general assumption of the LRH, no gesture facilitation effect was observed in the verb naming performance of IWA. Moreover, the majority of the IWA could perform iconic gestures in a similar way as language-unimpaired participants despite the presence of a hemiparesis or limb apraxia. Hence, the absence of a facilitation effect in the iconic gesture condition seems not to originate from an inability to produce adequate iconic gestures. Further research with more IWA is required in order to replicate our results.

Changes in local brain function in mild cognitive impairment due to semantic dementia.

AimsMild cognitive impairment due to semantic dementia represents the preclinical stage, involving cognitive decline dominated by semantic impairment below the semantic dementia standard. Therefore, studying mild cognitive impairment due to semantic dementia may identify changes in patients before progression to dementia. However, whether changes in local functional activity occur in preclinical stages of semantic dementia remains unknown. Here, we explored local functional changes in patients with mild cognitive impairment due to semantic dementia using resting‐state functional MRI.MethodsWe administered a battery of neuropsychological tests to twenty‐two patients with mild cognitive impairment due to semantic dementia (MCI‐SD group) and nineteen healthy controls (HC group). We performed structural MRI to compare gray matter volumes, and resting‐state functional MRI with multiple sub‐bands and indicators to evaluate functional activity.ResultsNeuropsychological tests revealed a significant decline in semantic performance in the MCI‐SD group, but no decline in other cognitive domains. Resting‐state functional MRI revealed local functional changes in multiple brain regions in the MCI‐SD group, distributed in different sub‐bands and indicators. In the normal band, local functional changes were only in the gray matter atrophic area. In the other sub‐bands, more regions with local functional changes outside atrophic areas were found across various indicators. Among these, the degree centrality of the left precuneus in the MCI‐SD group was positively correlated with general semantic tasks (oral sound naming, word‐picture verification).ConclusionOur study revealed local functional changes in mild cognitive impairment due to semantic dementia, some of which were located outside the atrophic gray matter. Driven by functional connectivity changes, the left precuneus might play a role in preclinical semantic dementia. The study proved the value of frequency‐dependent sub‐bands, especially the slow‐2 and slow‐3 sub‐bands.

Abstract P356: Wernicke’s Vertical Occipital Fasciculus in Post-Stroke Reading

Introduction: The vertical-occipital fasciculus (VOF), which was initially described by Wernicke more than a century ago but recently rediscovered, connects visual association cortices to the posterior language areas. We hypothesized that the vertical-occipital fasciculus plays a critical role in reading. Methods: Thirty-two participants with subacute to chronic left hemispheric stroke leading to varying degrees of aphasia were enrolled in the study and underwent concurrent diffusion tensor imaging (DTI) and language assessment. Assessments included the Boston Diagnostic Aphasia Examination (BDAE) to assess oral reading and reading comprehension and the Boston Naming Test to assess picture naming. Two major cortico-cortical projection pathways, VOF, connected with posterior language cortices and frontal aslant tract (FAT), connecting anterior language areas, were mapped with deterministic tractography and quantified bilaterally. We conducted partial correlations between fractional anisotropy (FA) values of the tracts and reading and picture naming scores, controlling for age, education, and total lesion load. We corrected for multiple comparisons at the false discovery rate (FDR) (p&lt;0.05). Results: FA of left VOF was found to be significantly correlated with BDAE total reading scores (r=0.49, p=0.004), and this remained significant after FDR correction (p=0.03). Although a significant correlation was seen between picture naming and left VOF FA (r=0.41, p=0.02), and right VOF FA (r=0.37, p=0.04), these associations were not significant after FDR correction (p&gt;0.05). FAT FA values were not significantly associated with oral reading or picture naming tests. Conclusion: This study provides preliminary evidence that left VOF plays a potential role in reading after left hemispheric stroke.

Intensive naming training for low-educated demented and non-demented elderly.

ABSTRACT.Complaints about naming difficulties may be common in the elderly. In dementia, anomia is the most frequent symptom of language disorders. Naming training can improve lexical access and promote better quality of communication for elderly with or without dementia.Objective:To analyze naming scores, response time and the generalization of responses for naming of neurotypical and demented low-educated older adults before and after receiving a naming training program, with and without oral comprehension stimulation.Method:Twenty elderly participants, 10 with dementia and 10 neurotypical, were included after interview, screening for cognition and functionality. The naming training was based on retrieval practice and carried out in 5 sessions. Half of the group underwent exclusive naming training, while the other half received naming training associated with oral comprehension stimulation.Results:Elderly people with dementia performed better after training for scores on oral naming and comprehension of oral words, except for object manipulation. The response time for naming trained and untrained stimuli was also better for elderly people with dementia. After the intervention, neurotypical individuals performed statistically better in comprehension time and in the score in oral naming, comprehension of oral words and object manipulation, for trained and untrained words.Conclusion:Naming training, exclusive or associated with oral comprehension, using the recovery technique benefits the language performance of neurotypical and demented elderly, and provides improvements even for untrained stimuli.

Verbal and non‐verbal auditory comprehension tests in early diagnosis of Alzheimer's disease

AbstractBackgroundThe purposes of this study are to correlate auditory comprehension impairment with AD early development and to evaluate the verbal and non‐verbal auditory comprehension tests for early diagnosis of AD.MethodThe 24 healthy controls (HC), 30 amnestic mild cognitive impairment (aMCI) and 27 mild AD (mAD) patients were recruited. The verbal (yes‐or‐no question, listening identification and oral instruction) and non‐verbal (sound categorization, emotion judgment, beat judgement, sound naming) auditory comprehension tests were adapted to evaluate the diagnostic ability of auditory comprehension. The receiver operating characteristic curves were used to analyze the diagnostic values.ResultAll tests except for yes‐or‐no question presented moderate or higher level of positive correlation in the scores with Mini‐Mental State Examination (MMSE) and Montreal Cognitive Assessment (MOCA), among which sound naming and oral instruction were the best. Statistical analysis identified a significant difference of sound naming and verbal auditory comprehension tests in aMCI group compared with the HC group. In addition, the mAD group exhibited statistically significant difference in sound categorization, sound naming, beat judgement and oral instruction when compared with the other two groups. Oral instruction sound categorization and naming benefited better in early diagnosis than the other subtests.ConclusionThe impairments of auditory comprehension emerge early in AD, or even aMCI patients, which worsen with the progression of the disease. The tests of sound categorization, sound naming and oral instruction exhibited better discriminative values, which might be beneficial for the early diagnosis of AD.

Individual differences in learning the regularities between orthography, phonology and semantics predict early reading skills.

Statistical views of literacy development maintain that proficient reading requires the assimilation of myriad statistical regularities present in the writing system. Indeed, previous studies have tied statistical learning (SL) abilities to reading skills, establishing the existence of a link between the two. However, some issues are currently left unanswered, including questions regarding the underlying bases for these associations as well as the types of statistical regularities actually assimilated by developing readers. Here we present an alternative approach to study the role of SL in literacy development, focusing on individual differences among beginning readers. Instead of using an artificial task to estimate SL abilities, our approach identifies individual differences in children's reliance on statistical regularities as reflected by actual reading behavior. We specifically focus on individuals' reliance on regularities in the mapping between print and speech versus associations between print and meaning in a word naming task. We present data from 399 children, showing that those whose oral naming performance is impacted more by print-speech regularities and less by associations between print and meaning have better reading skills. These findings suggest that a key route by which SL mechanisms impact developing reading abilities is via their role in the assimilation of sub-lexical regularities between printed and spoken language -and more generally, in detecting regularities that are more reliable than others. We discuss the implications of our findings to both SL and reading theories.

Modified semantic feature analysis for anomia: a single case study

ABSTRACTSemantic feature analysis (SFA) is a treatment approach designed for patients with lexical retrieval difficulty caused by semantic deficits. During training, a structured framework (e.g. requiring the patient to name the category, function, and colour of the target items) is usually provided to facilitate the patient in thinking of the semantic features of the target items. Nevertheless, the use of a structured framework potentially limits the variety of semantic features activated for lexical retrieval. This study investigated the effectiveness of modified SFA training to address this potential limitation. An odd-man-out task was carried out in the modified SFA training with an anomic patient with impaired access to the phonological output lexicon. The task aimed to encourage a detailed comparison of semantic features among items in the same category. It is hypothesized that activations of more distinctive semantic features belonging to the target items will result in greater extent of generalizations in the lexical processing. The patient’s abilities in naming semantic features at the beginning and at the end of each treatment session were compared. Besides, accuracy and error patterns in oral and written naming in the initial and post-treatment assessment were also compared. The results showed a significant increase in the number of semantic features retrieved within treatment sessions. Moreover, a significant improvement in oral picture naming was also observed subsequent to the modified SFA training. Finally, the results of the error analyses further supported that the modified SFA was effective in promoting overall lexical processing. The findings indicated that both quantity and distinctiveness of concepts activated in the semantic system are essential to effective lexical retrieval. Theoretical and clinical implications were also discussed.

Italian norms and naming latencies for 357 high quality color images.

In the domain of cognitive studies on the lexico-semantic representational system, one of the most important means of ensuring effective experimental designs is using ecological stimulus sets accompanied by normative data on the most relevant variables affecting the processing of their items. In the context of image sets, color photographs are particularly suited to this purpose as they reduce the difficulty of visual decoding processes that may emerge with traditional image sets of line drawings. This is especially so in clinical populations. In this study we provide Italian norms for a set of 357 high quality image-items belonging to 23 semantic subcategories from the Moreno-Martínez and Montoro database. Data from several variables affecting image processing were collected from a sample of 255 Italian-speaking participants: age of acquisition, familiarity, lexical frequency, manipulability, name agreement, typicality and visual complexity. Lexical frequency data were derived from the CoLFIS corpus. Furthermore, we collected data on image oral naming latencies to explore how the variance in these latencies could be explained by these critical variables. Multiple regression analyses on the naming latencies show classical psycholinguistic phenomena, such as the effects of age of acquisition and name agreement. In addition, manipulability was also a significant predictor. The described Italian normative data and naming latencies are available for download as supplementary material.

Electrical stimulation of the left IFG improves category fluency in primary progressive aphasia: far-transfer effects and their neural mechanisms

Electrical stimulation of the left IFG improves category fluency in primary progressive aphasia: far-transfer effects and their neural mechanisms

A behavioral study of the nature of verb–noun dissociation in the nonfluent variant of primary progressive aphasia

ABSTRACTBackground: Patients with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) have more difficulty producing verbs than nouns, but the reason for this discrepancy remains unclear. One possibility is that it results from impaired access to motor programs integral to semantic representations of actions. Another is that the disruption affects specific lexical or grammatical features of verbs.Aims: To use an oral picture naming task to examine the effects of motor associations on verb production in patients with nfvPPA.Methods & Procedures: We administered noun and verb naming tasks to 12 nfvPPA patients and 9 controls. We varied the manipulability of target items across categories as a proxy for the degree to which lexical access depends on motor knowledge.Outcomes & Results: Nonfluent PPA patients were significantly more impaired in both noun and verb naming compared to control participants. However, the nfvPPA patients were significantly more impaired in naming verbs than nouns, but there was no effect of manipulability.Conclusions: The results suggest that the verb naming deficit in nfvPPA is not directly related to impaired motor knowledge and is more likely to be related to other properties that distinguish verbs from nouns.