Oral Mucosal Lesions Research Articles

CHALLENGES OF ORAL HEALTH IN PATIENTS WITH BULLOSA EPIDERMOLYSIS: CROSS-SECTIONAL STUDY

Objectives To investigate the oral health of patients with epidermolysis bullous (EB). Moreover, this study aims to show the importance of the role of the dentist in improving patients’ quality of life. Study Design In a cross-sectional study, the oral health of all patients with EB was evaluated. The findings were collected and compiled in Excel. Statistical analyses were performed using EPINFO 7.0. Results Twelve patients were evaluated; the majority were female (7 cases; 58.0%) and in the second decade of life (25.0%). One patient reported having a family member with the disease (8.3%), and there was 1 case of carcinoma due to complications of the disease (8.3%). The main oral alteration was ulcers in the oral mucosal (7 cases; 58.3%), followed by carious lesion (5 cases; 41.7%) and endodontic alterations (4 cases; 33.3%). There was a significant statistical association between oral mucosal lesions and pain (P = .024). This pain was relieved through photobiomodulation therapy performed by the dentist. Conclusions The main oral alteration diagnosed was oral mucosal lesion and it was associated with pain. The dentist was important to reduce the pain and improve the quality of life of these patients. To investigate the oral health of patients with epidermolysis bullous (EB). Moreover, this study aims to show the importance of the role of the dentist in improving patients’ quality of life. In a cross-sectional study, the oral health of all patients with EB was evaluated. The findings were collected and compiled in Excel. Statistical analyses were performed using EPINFO 7.0. Twelve patients were evaluated; the majority were female (7 cases; 58.0%) and in the second decade of life (25.0%). One patient reported having a family member with the disease (8.3%), and there was 1 case of carcinoma due to complications of the disease (8.3%). The main oral alteration was ulcers in the oral mucosal (7 cases; 58.3%), followed by carious lesion (5 cases; 41.7%) and endodontic alterations (4 cases; 33.3%). There was a significant statistical association between oral mucosal lesions and pain (P = .024). This pain was relieved through photobiomodulation therapy performed by the dentist. The main oral alteration diagnosed was oral mucosal lesion and it was associated with pain. The dentist was important to reduce the pain and improve the quality of life of these patients.

Comparison of terahertz and ultrasound imaging in the assessment of oral soft tissue lesions

<h3>Objective</h3> To evaluate the diagnostic efficacy of terahertz (THz) beams in intraoral soft tissue lesions by comparing them with ultrasonography. <h3>Study Design</h3> Ethical Approval was obtained for the present study. Intraoral lesions of patients who were examined in Ankara University, Dentistry Faculty, Dentomaxillofacial Radiology Department were included in this study. A total of 30 oral mucosal lesions were assessed by using high frequency ultrasound ACUSON S 2000 (Siemens, Munchen, Germany) and Terahertz Attenuated Total Reflection (ATR) method. Characteristic and dimensional measurements of the lesions were compared. Ultrasonography assessment was conducted by using a 15 MHz intraoperative probe. Lesions were excised after ultrasonographic examination. After excision, assessment of excised lesions was conducted at our laboratory by use of Terahertz Attenuated Total Reflection (ATR) in the light. One researcher assessed the measurements twice at two different times. Measurements were compared by Bland and Altman and intraclass correlation coefficients (ICC). Significance was established at <i>p</i> < 0.05. <h3>Results</h3> ICC values calculated for intraobserver agreement for all measurements were found to be statistically significant (<i>p</i> <0.001). In general, for ultrasound measurements we found a mean difference ranging between -0.120 and +0.230 mm in comparison to THz. <h3>Conclusion</h3> THz imaging can be suggested as a promising technology and an adjunct to common imaging modalities in the assessment of oral soft tissue lesions. <b>Statement of Ethical Review</b> Human/Animal subjects were used and this study was approved by an institutional ethics panel

Factors Related to Oral Mucosal Lesions Among Tobacco Smokers in A Fisher Community of Indonesia

Factors Related to Oral Mucosal Lesions Among Tobacco Smokers in A Fisher Community of Indonesia

A Prospective Comparative Analysis Regarding the Assessment of Oral Mucosal Disease Using a Validated Questionnaire to Improve the Teaching of Dental Students.

Structured examination and treatment are essential in medicine. For dental students, a structured approach to the assessment of oral mucosal lesions is missing thus far. To validate an approach, a structured questionnaire was compared with the habitually used free description of oral lesions (white lesions, ulcers, hyperplasia). Thirty-three dental students were divided into two groups (Group 1 (n = 17) used the free description; Group 2 (n = 16) used a guided questionnaire) to characterize mucosal lesions in patients and make a tentative diagnosis. Although no difference was found between the groups regarding the suspected diagnosis or the histopathological findings, there was a significant advantage of the structured questionnaire in all aspects of the description compared to the free description (p = 0.000018). Thus, a structured description is an important aspect in the evaluation of oral mucosal changes, and a guided questionnaire should be implemented in the study of dentistry.

Prevalence of tobacco-associated oral mucosal lesion in Hazaribagh population: A cross-sectional study.

Smoking and chewing tobacco carry significant risks for the development of oral cancer and premalignant lesions. The present study was conducted to find the prevalence of tobacco-related habits in Hazaribagh population and its association with oral mucosal lesion. The present study was carried out on patients who visited the Department of Oral Medicine And Radiology, Hazaribagh College of Dental Sciences And Hospital. A total of 5,000 subjects were screened for tobacco-related habits and associated mucosal changes. Detailed clinical history about tobacco-related habits was obtained. Oral mucosal lesions were screened using the WHO format for diagnosis of oral lesions. The findings were tabulated and analyzed statistically. Of the 5,000 subjects enrolled for the study, 1,085 (21.7%) used tobacco in some forms. Habit of smoking tobacco was present among 273 (25.2%) and using smokeless tobacco among 811 (74.7%) individuals. Tobacco pouch keratosis (46.1%) was found to be most common lesion, followed by oral submucous fibrosis (OSMF) (16.1%), lichenoid reaction (14.1%), smokers palate/melanosis (12.2%), leukoplakia (7.2%), erythroplakia (2.3%), and oral cancer in (2%). The results provide insight into prevalent tobacco habits and associated oral mucosal lesions in Hazaribagh population. These may act as baseline data for the formulation of preventive programs and help future studies explore the prevalence of tobacco-associated lesions in vulnerable populations. Current knowledge, including findings from the present study, about the prevalence of tobacco use and various oral lesions associated with it may help primary health care physicians to promote among patients visiting them the awareness about the adverse effects of tobacco consumption and treatment options available for tobacco-related lesions at the early stage.

Oral Mucosal Lesions in Moderate-to-Severe COVID-19 Disease – An Indian Critical Care Unit Experience

Severe acute respiratory syndrome coronavirus 2 is a widespread worldwide public health malady due to a viral COVID-19 infection. The World Health Organization has affirmed this malady as a pandemic and Public Health Emergency of International Concern. A wide array of oral lesions has been reported in patients with COVID-19. Oral lesions can be an initial sign of COVID-19 or an alarming sign of peripheral thrombosis. However, there is a scarcity of published literature on the oral manifestations of COVID-19 in hospitalized patients. We present four different types of oral lesions in hospitalized patients with moderate-to-severe COVID-19 disease. This article proposes that a detailed examination of the oral cavity in patients admitted to COVID-19 intensive care unit/high dependency units will help to understand the significance of the oral lesions in the management of the disease. Dental professionals should be a part of the multidisciplinary treatment protocol, thus, emphasizing a detailed and meticulous oral examination and oral health amelioration of COVID-19 patients.

Oral lesions of viral, bacterial, and fungal diseases in children: A decision tree.

Oral mucosal lesions are common in the pediatric population and, apart from traumatic and tumoral etiologies, they can be symptoms of viral, bacterial, fungal or parasitic diseases. Yet, pediatricians and pediatric dentists find it challenging to reach a diagnosis and provide appropriate care when facing lesions of the masticatory or lining mucosa, of the hard or soft palate, of the tongue or salivary glands. Here, we propose a decision tree for the diagnosis of the most frequent viral, bacterial, and fungal diseases starting from their oral lesions in children. By first focusing on describing the elementary lesion itself before its localization and characteristics, it aims to guide the practitioner toward the diagnosis and any necessary complementary exams. To generate this tool, we conducted a literature review of the childhood viral, bacterial, fungal and parasitic diseases with oral mucosal symptoms. For each of the 42 reported diagnoses−20 viral, 9 bacterial, 5 fungal, and 8 parasitic—we collected the infection mechanism and agent(s), the oral lesions and their description, the associated systemic signs and the incidence/prevalence. In fine, our decision tree indexes the 28 diseases for which epidemiological data was available, mainly in Europe and the United States.

Morphological Changes in the Oral Mucous Membrane in Viral Hepatitis C Patients: A Cross-Sectional Study.

Background: The objective was to reveal the most typical changes in oral mucosa in HCV patients and compare them with those in HCV negative patients. Methods: The study involved 96 HCV patients and 100 patients without HCV who applied to a dental clinic. The content of cytokines IL-2, IL-4, IL-10 and ɤ-INF in the oral fluid was determined by ELISA. Buccal mucosa and gums biopsies passed histological examination. An immunohistochemical study of mucous membrane biopsies was performed using monoclonal mouse antibodies to CD3+ and CD20+. Results: The HCV patients group included 96 (63.5% males), and the non-HCV group included 100 subjects (62.0% males) with lesions of the oral mucous membrane. The lesions of lips and oral mucosa were more frequent in HCV than in the non-HCV group—e.g., erosion (13.5% vs. 1%), cracks in the mouth corners (42.7% vs. 0%), changes in the oral mucosa surface (89.6% vs. 3.0%), hemorrhages (78.1% vs. 0%), etc. The pro-inflammatory IL-2 level was higher and anti-inflammatory IL-4 level was lower in HCV patients compared with those in the non-HCV group. Conclusions: Morphological changes developed in the microvasculature both worsen the tissue trophism and accelerate the healing with differentiation into coarse-fibrous connective tissue. Immunohistochemical findings indicated a decrease in local humoral immune response.

Comprehensive interdisciplinary principle of diagnostics and treatment of oral mucosa lesions in psoriasis

BACKGROUND: Psoriasis on the oral mucosa is not often diagnosed by practicing dentists, as it occurs in 23% of patients. Various factors are of primary importance in the occurrence and development of this pathology.&#x0D; AIM: This study aimed to present a clinical case of psoriasis lesions in the oral mucosa to determine a set of interdisciplinary diagnostic and therapeutic measures for combined lesions of the skin and oral mucosa in patients with psoriasis.&#x0D; MATERIAL AND METHODS: Changes in the mucous membrane of the tongue in a patient with psoriasis vulgaris is described. The manifestations in the oral cavity were identified as ICD-10-L40.0X.&#x0D; RESULTS: A combination of diagnostic and therapeutic measures is presented with simultaneous manifestations of the disease on the skin and in the oral cavity.&#x0D; CONCLUSION: The presented clinical example demonstrates the need for a comprehensive interdisciplinary examination and consultation with doctors of different specialties. For differential diagnosis and determination of the disease course, prognosis, and main research methods, it is necessary to perform histological examination of the biopsy of the pathological site of the oral mucosa, and if necessary the skin, and autofluorescence stomatoscopy of the oral mucosa and tongue. The described diagnostic and therapeutic measures will contribute not only to stopping the disease recurrence but also to reducing the level of stress, carcinophobia, and thereby improve the quality of life of the patients.

Prevalence of precancerous lesions and conditions in India: A systematic review and meta-analysis.

BACKGROUNDSmoking and chewing tobacco are associated with numerous oral mucosal lesions and conditions, often leading to cancer progression. AIMTo investigate the prevalence of precancerous lesions and conditions among the Indian population.METHODSSystematic search was conducted for population or community-based observational epidemiological studies in PubMed, EMBASE, Web of Science, IndMED, Google Scholar, reports of the WHO South-East Asia Region, MOHFW India reports, Science Citation Index, WHO Index Medicus of the South-East Asian Region, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and Open Grey from the earliest available up to 31st January 2022. The effect size was calculated for the prevalence of precancerous lesions and conditions. RESULTSOne hundred sixty-two estimates from 130 studies yielded 52 high, 71 moderate, and seven low-quality studies from 823845. Point estimate based on cross-sectional studies for leukoplakia was 4.3% (95%CI: 4.0-4.6), oral submucous fibrosis was 2.7% (95%CI: 2.5-3.0), palatal lesions in reverse smokers and nicotine palatine were 5.8% (95%CI: 4.4-7.2), and Erythroplakia was 1.2% (95%CI: 0.7-1.7), and lichen planus was 1.1% (95%CI: 0.9-1.2). Amongst hospital-based studies, the pooled prevalence for Leukoplakia was 6.7% (95%CI: 6.0-7.3), oral submucous fibrosis was 4.5% (95%CI: 4.2-4.9), lichen planus was 7.5% (95%CI: 5.3-9.6), and erythroplakia was 2.5% (95%CI: 0.4-4.5), and palatal lesions in reverse smokers and nicotine palatini were 11.5% (95%CI: 8.0-15.0). CONCLUSIONPrecancerous lesions and conditions are prevailing problems among the Indian population. It is mainly due to tobacco use, the smokeless form of tobacco. The meta-analysis indicates that hospital-based studies have a higher effect size of 6.7% than community-based studies. Patients who have already developed this condition may be advised to reduce their exposure to the risk factor to prevent the condition from progressing further.

277 Treatment of aphthous ulcers with montelukast

Aphthous ulcers are the most prevalent oral mucosal lesions, yet treatment is challenging. There is evidence that oral montelukast is efficacious in treating aphthous ulcers. A randomized placebo-controlled trial comparing montelukast against prednisone for recurrent aphthous stomatitis demonstrated montelukast has superior efficacy compared with placebo, decreased efficacy compared with prednisone, but decreased adverse effects compared to prednisone. Our single-center, retrospective study identified subjects with a minimum of 2 distinct encounters using the search term:(Singular or montelukast) AND (aphthous ulcers).

The effect of a non-tobacco-based nicotine pouch on mucosal lesions caused by Swedish smokeless tobacco (snus).

Oral mucosal lesions are commonly found in Swedish smokeless tobacco (snus) users where the pouch is placed. These lesions are reversible, that is, clinical and histological tissue changes return to normal following cessation. However, the exact mechanisms behind these changes are unknown. The main aim of this study was to investigate how snus‐like non‐tobacco‐based nicotine pouches affect the oral mucosa and the severity of pre‐existing lesions. Sixty regular users of Swedish smokeless tobacco were encouraged to substitute their snus with non‐tobacco‐based nicotine pouch products during a 6‐week period. Meanwhile, oral mucosal lesions were assessed using a four‐degree scale. Over time, a reduction of pre‐existing mucosal lesions was observed between baseline and the final visit. In a second part, the effect of exposure to regular snus on the production of 48 different cytokines in peripheral blood mononuclear cells was compared in vitro with that resulting from exposure to the non‐tobacco‐based nicotine products. Results showed significantly increased production of proinflammatory cytokines in cells exposed to regular snus compared to untreated or cells exposed to the non‐tobacco‐based nicotine products. This may be related to the improved clinical appearance of the oral mucosa in the participants that used the non‐tobacco‐based nicotine test pouches.

Clinicopathological Evaluation of Tobacco-related Oral Mucosal Lesions

To clinically evaluate the nature of precancerous and cancerous lesions associated with tobacco consumption habit and to correlate clinical profile with the histopathological findings of clinically suspected precancerous and cancerous lesions. These included the examination of patients who visited the outpatient department (OPD) of the institute that includes 1,500 patients who had tobacco chewing habits were classified into the following two groups according to their characteristics. The study group comprised 270 patients, of which 170 gave consent for biopsy and 100 patients who not gave consent were counseled for tobacco cessation. Among 270 patients, the highest number of patients, 146 (54.07%) patients, were found to be smokeless tobacco consumers followed by 65 (24.07%) patients who were smoked tobacco consumers while 59 (21.85%) patients were found to have both the habits. Wide variation was noted in duration and frequency of habit. Most prevalent site was the buccal mucosa affected in 138 (51.11%) patients who consumed both smoked as well as smokeless tobacco. And on clinical examination, 138 (51%) patients had leukoplakia followed by 54 (20%) patients with oral squamous cell carcinoma and 40 (15%) patients with oral submucous fibrosis (OSMF). Other patients were tobacco pouch keratosis 17 (6%), smoker's melanosis 8 (3%), smoker's palate 7 (3%), and erythroplakia 6 (2%). The patients who gave consent (170 patients) were evaluated histopathologically to correlate with clinical findings. Tobacco-related oral lesions are also high, which brings an alarming signal toward the development of cancer. Our contribution as healthcare providers can be made by conducting more oral health education programs and educating the general population about the adverse effects of tobacco. The appropriate clinical assessment and categorization of all these lesions aided us in motivating patients to undergo necessary treatments and also to discontinue their habits in order to prevent deterioration of their conditions. Set up de-addiction centers in dental colleges and help tobacco users in discontinuing their habits. Interestingly, this study also served as a mirror for those patients who were unaware of the lesions they were giving abode to in their oral cavities.

PREVALENCE OF ORAL MUCOSAL LESIONS AMONG DENTAL PATIENTS IN BAREILLY POPULATION: AN ORIGINAL RESEARCH

Aim: Methodology:To determine the prevalence of oral mucosal lesions among dental patients in Bareilly population. Subjects of the either sex reporting to the Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bareilly, India, were included in the study after obtaining their informed consent. Examination of the oral cavity was performed under good illumination using gloves, probe, mirror according to Kerr, Ash, Millard and WHO guidelines and color atlas was followed during examination. Oral mucosal lesions were diagnosed based on the clinical features. When clinical diagnosis was inconclusive, histopathological evaluation was done. There were total 2000 patients within 16 -70 yearsResults: range; Mean age of patients was 43.83 ± 15.38 years. It was found that 1393 (69.7%) out of 2000 of oral mucosal lesions, maximum was 553 (27.7%) of leukoplakia, 319 (16%) of tobacco pouch keratosis, 180 (9%) of smoker's palate, 151 (7.6%) of oral submucous brosis. Conclusion: This study presented epidemiological data on oral mucosal lesions associated with the tobacco habit of the Bareilly city in UP, India. This might prove valuable in identifying high-risk populations, planning future oral health studies and implementing preventive programmes. In our study, we found that the tobacco habit was most prevalent in the age group of 41 to 50 years.

Oral health status and oral health related quality of life in Kodhu tribes – A descriptive cross sectional study

Introduction: In this modern era, a significant group of people is living in isolated hilly areas far away from civilization with their custom and beliefs. They are known as “tribes.” “Kodhu” tribe is one of the major Indian tribes present in the remote areas of Visakhapatnam. The objective is to assess the oral health status and oral health-related quality of life and education level in Kodhu Tribe in residing in Araku and Paderu regions of Visakhapatnam. Material and Methods: A descriptive cross-sectional study was conducted among the Kodhu tribal population situated in the Araku and Paderu areas Visakhapatnam, Andhra Pradesh. The study comprised of 800 participants selected using a simple random sampling technique. Chi-square test was used to assess the oral health status of the tribal population, while, independent t-test was used for multiple comparison of OHIP-14 and oral health status. A p-value ≤ 0.05 was considered statistically significant. Results: Among 800 participants, 458 were illiterate, and 342 were literate. The prevalence of dental caries was 49% among the illiterates while literates had 50.4% prevalence and the difference was statistically significant (P &lt; 0.03). The periodontal status prevalence was found to be higher in illiterates (56.4%). The domains that are present in OHIP were found to be significantly associated with dental caries, periodontal status, and oral mucosal lesions (P &lt; 0.001). Conclusion: The oral health status of Kodhu tribe was found to have high prevalence of the periodontal disease and dental caries. Regular oral examination by dental professionals, dental health education, and motivation to maintain oral hygiene should be insisted to improve the oral health status of this tribal community.

Oral Mucosal Lesions Possibly Associated with COVID-19

Oral Mucosal Lesions Possibly Associated with COVID-19

PREVALENCE OF ORAL MUCOSAL NORMAL VARIATIONS IN A GERIATRIC POPULATION OF CHHATTISGARH- A REAL WORLD EVIDENCE

The incidence of OMLs is thought to extend with age, because of physiological changes within the oral cavity and also because of the sustained impact of risk habits. Other predisposing factors within the elderly include decreased saliva flow and long-lasting effects of local and systemic factors, like alcohol intake, smoking, snuff and drug use. The importance to differentiate normal conditions from pathological lesions lies within the proven fact that the normal variations don't need any medical intervention. Oral mucosa may be a harbor to several such normal variations which can confuse the diagnosis among the budding dentists. So, proper knowledge about their existence, prevalence and features are very important. The search of the literature revealed no such studies in Chhattisgarh Population, warranting a quick need to carry out a study to understand the prevalence of oral mucosal normal variations in the geriatric Chhattisgarh Population.&#x0D; AIM- The aim of our study is to search out the prevalence and to achieve more knowledge about oral normal soft tissue variations in the geriatric Chhattisgarh Population and possibly identify new avenues of research in this area.&#x0D; METHOD- It is a Prospective and observational correlation study, performed in an exceedingly period of two years from 2015-2017 within the Department Of Oral Medicine and Radiology at Chhattisgarh Dental College and Research Institute, Rajnandgaon, (Chhattisgarh), India. It included the patients of age 60 years and above of Chhattisgarh Population.&#x0D; RESULT- The most prevalent normal variation in this study was found to be fissured tongue 46% followed by coated tongue (20%), depapilation of tongue (20.3%), Melanosis (9.7%), lingual varicose (1.4%), leukoedema (1.1%), Fordyce's granules (0.7%) and geographic tongue (0.14%).&#x0D; CONCLUSION- The present study renders sufficient information about the epidemiologic aspects of oral mucosal normal variation in the geriatric population which may prove valuable in the planning of future oral health strategies of this group of the Indian population. This will further enhance community programs to educate the elderly population, along with the younger generation to get the elderly screened for any deviation from these variations or any oral mucosal lesions by availing adequate clinical and pathological laboratory facilities, which will ensure a good quality of life in this population of interest.

Oral lesions during dermatomyositis treatment: A case report

Dermatomyositis is an inflammatory autoimmune disease that causes significant muscle damage. The diagnosis and treatment of this disease commonly requires both therapeutic and dental care. This article describes a clinical case of dermatomyositis where the patient has been receiving therapy since 2018. Stable disease remission was achieved with therapy, with dual-energy X-ray absorptiometry (DXA) indicating an improvement in bone tissue parameters. However, despite this remission, the patient experienced progressive dental manifestations (characteristic complaints, presence of oral mucosal lesions, destruction of jawbone structures). The primary cause of these dental manifestations was not found to be local oral cavity factors, suggesting they were the consequence of both disease pathology and steroid treatment that targeted the oral cavity tissues. The collaboration between an internist and dentist contributed to the early diagnosis and prevention of possible complications associated with this disease.

Association of Tobacco Smoking with Systemic Co-Morbidities among Patients Seeking for Dental Care Services: Across Section Study

Background: Smoking is a common risk factor for chronic diseases, including cancer, lung diseases and cardiovascular disease. The adverse effects of tobacco smoking on oral health are well documented. This includes common and rare conditions of benign to life-threatening diseases such as bad breath, discoloration of teeth and dental restorations, taste and smell disorders , periodontal disease , oral mucosal lesions such as smoker's melanosis and smoker's palate, potentially malignant lesions and oral cancer . Aim of the Study: To verify associated of the smoking with systemic dissase among patients seeking for dental health care Patients and methods: A cross-sectional study performed at the dental and maxillofacial unit in AL-Sader Teaching hospital, Al-Najaf city the data were collected during a period of four months, starting 1st March to the 1st June 2019. Target population: study participants were selected by systemic random sampling patients attended Al Sader Teaching hospital at maxillofacial unit according to special criteria. Results: A total of 400 participants were enrolled in this study , their age ranged 18 – 65 years, no significant difference had been found regarding the age distribution between smokers and non-smokers sub groups, (P&gt;0.05). No significant association was found between smoking and residence, (P&gt;0.05). A significant association was found between occupation and smoking status , where unemployed were the dominant among smokers, contributed for 52.9%, compared to other occupations, (P = 0.001). Conclusions: Significant associated with observed between oral disease and cigarette smoking among patient seeking oral health care.

Knowledge, Attitude and Practices towards Drug Prescription for Oral Mucosal Lesions in Saudi Arabia

Oral mucosal diseases are common in routine dental practices and significantly influence patients’ quality of life. Dental students should be aware about the management of oral mucosal diseases as well as the major oral diseases such as dental caries, gingivitis and periodontitis. This study aimed to evaluate, attitudes and practices of dental students regarding management of certain oral mucosal conditions. This is a cross sectional KAP study conducted among dental students in Saudi Arabia. Inclusion criteria were students in 4th academic year or higher, since these students should study the pharmacological courses starting from the 4th academic year. The sample included 300 students to whom questionnaires were distributed. Chi-square test of homogeneity was used to detect significant differences in students’ knowledge, attitudes and practices based on students’ characteristics. The level of knowledge about the studied oral mucosal diseases was high in 62.7% of dental students, while only 2% had low level of knowledge. The attitude of the students was good in 48%, however 11.7% had poor attitude towards drug prescription of the medications for theses oral mucosal diseases. The practices of the dental students in prescription of medications during their clinical training were good in 16%, while it was poor in 31% of dental students. The knowledge regarding drug prescription for oral mucosal drugs were high among the majority of dental students, however the prescription practices were poor when compare to the level of knowledge.