Postoperative manifestations like pain, edema, affected oral functions provoke transitory morbidity in patients to a late recovery. Various classes of medicines are prescribed to prevent placing patients in such unpleasant situations. Both dexamethasone and methylprednisole can be used to reduce the manifestations of the postoperative disease. Although the state of local inflammation is precursory to healing, its exacerbation can lead to extremely painful severe local edema through tissue distention. In the initial phase of the inflammatory process, glucocorticoids act as producers of vein-active substances like prostaglandins and leukins, as dexamethasone has a recognised capacity of reducing COX-2, which is responsible for generating PGs which are produced within the inflammatory response. The efficiency of glucocorticoids is admitted in reducing the inflammatory state, lying at the top of oral maxillofacial surgeons�s choice in the therapy of postoperative manifestations. Our research was addressed to a lot of 68 patients to whom we performed interventions of oral and maxillofacial surgery at the Outpatient Clinic of Oral-Maxillofacial Surgery of Ia�i. Dexamethasone is a strong glucocorticoid with the following chemical formula: 90-fluoral-160 methylprednisole. The antiinflamatory effect of a 0.75 mg dosis of dexamethasone is equivalent to that produced by 5 mg of Prednison. Dexamethasone is more efficient than Medrol in the treatment of postoperative edema with complete remission of symptomatology.
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Sep 1, 2023
Saxon T Day + 7
Open Access