Oral Manifestations In Patients Research Articles

WHAT DOES THE DENTIST NEED TO KNOW ABOUT SJÖGREN SINDROME? A NARRATIVE REVIEW

<h3>Objectives</h3> The aim of this study was to conduct a review demonstrating the main oral manifestations in patients with Sjögren's syndrome and its consequences on their quality of life, highlighting the importance of the dentist in the diagnosis of this systemic disease. <h3>Study Design</h3> A search was performed in the databases ScienceDirect, Google Scholar, and PubMed from 2012 to 2020, highlighting its relevance. <h3>Results</h3> The search resulted in 11 articles that were included in this review. The main oral manifestations found in patients with Sjögren's Syndrome were as follows: hyposalivation; resulting in oral mucosa dryness and ulcerated lesions; fungal infections; and tooth loss due to caries lesions. These changes have a major negative impact on the quality of life of these people, and many of them first turn to the dentist to solve the problem. <h3>Conclusions</h3> Based on this review, the dentist must be able to know the main oral alterations of this disease. The multidisciplinary approach involving dentists and doctors, mainly the rheumatologist, is extremely important to guarantee the best treatment for the patient.

Oral Manifestations of Psychotropic Drugs on the Oral Cavity: Observational Study

This study aims to detect the prevalence of oral manifestations in patients with psychiatric disorders on psychotropic medications. A total of 46 patients above the age of 18 years who have been diagnosed with psychiatric illness and under psychotropic medications were included in this study. Thorough case history and oral findings were recorded. Patients with already existing systemic illness and other oral manifestations were excluded from this study. Out of 46 patients, 34 patients presented with oral manifestations such as xerostomia, sialorrhea, geographic tongue, candidiasis, and burning mouth syndrome, secondary to the use of psychotropic medications. The oral manifestations were significantly higher in the patients under antipsychotics (80.0%), selective serotonin reuptake inhibitor (66.7%), antiepileptics (55.6%), antidepressants (44.4%), benzodiazepine (44.4%), and tricyclic antidepressants (13.7%). The commonly used psychotropic medications to treat patients with psychiatric illnesses such as selective serotonin reuptake inhibitor, tricyclic antidepressants, antidepressants, and benzodiazepines exhibited several oral manifestations. However, long-term use of these medications seems to cause oral changes. Awareness among psychiatrists about oral changes associated with the use of psychotropic medication will assist them to make necessary modifications in the prescriptions. Dental practitioners will be able to recognize these changes early in the course of the condition and provide appropriate treatment.

Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study.

Background: Several systemic diseases manifest themselves in the oral cavity. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: The present cross-sectional study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr El Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Patients' medical records were evaluated. The oral manifestations were assessed according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in SLE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with SLE as the WHO considers oral manifestations of SLE a widespread state. Also, the implementation of oral hygiene measures to improve patients' nutritional state and health-related quality of life is recommended.

Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study

Background: Several systemic diseases manifest themselves in the oral cavity. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: A descriptive study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr EL Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Moreover, patients’ medical records were also evaluated. The oral manifestations were recorded according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in SLE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with SLE as the WHO considers oral manifestations of SLE a widespread state. Also, implementation of oral hygiene measures and treatment to improve patients’ nutritional state and health-related quality of life are recommended.

Management of patients with aphthous-like ulcers related to aplastic anaemia in the COVID-19 pandemic era through teledentistry: A case report

Background: Aplastic anaemia is a disease that occurs when the body fails to produce enough blood cells. Oral lesions, such as canker sores, are often used as an early marker of this disease condition. In the COVID-19 pandemic era, a teledentistry method is expected to assist in the management of patients with various diseases including aplastic anaemia. Purpose: This case report discusses the management of patients with aphthous-like ulcers related to aplastic anaemia in a 34-year-old woman, based on history, clinical examination, and blood tests through teledentistry. Case: The patient complained of a bleeding wound on the inner left cheek and corner of the left lip that appeared one month ago. There was an ulcer lesion that was bleeding easily in the buccal mucosa sinistra and the angular sinistra, as well as macules lesion on her hand and foot. The complete blood count test exhibits a low platelet level. Case management: The diagnosis was an aphthous-like ulcer related to aplastic anaemia. Patient was treated with topical antiseptic and anti-inflammatory mouthwashes for the oral lesions, as well as collaboration with the medical team. The lesions improved after the patient received a blood transfusion and drug therapy from the internist while she was hospitalized, but the lesions reappeared in other locations in the oral cavity when the platelet level dropped. Conclusion: Management of oral manifestations in patients with aphthous-like ulcers related to aplastic anaemia in the COVID-19 pandemic era can be done through teledentistry. However, this requires sensitivity from the dentist, patient compliance in following instructions, and the involvement of a multidisciplinary approach, such as collaboration with internists to achieve recovery. Delay in detecting and treating aplastic anaemia will lead to death, as in this case.

Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study

Background: Several systemic diseases manifest themselves in the oral cavity. Oral manifestations of lupus erythematosus (LE) are associated with a significantly increased risk of cancer. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: A descriptive study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr EL Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Moreover, patients’ medical records were also evaluated. The oral manifestations were recorded according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in LE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with LE as the WHO considers oral manifestations of LE a widespread state. Also, implementation of oral hygiene measures and treatment to improve patients’ nutritional state and health-related quality of life are recommended.

Oral manifestations in patients with covid 19

El 2019-nCoV se llama oficialmente SARS-CoV-2 y causa la enfermedad llamada COVID 19, la cual es considerada pandemia por la Organización Mundial de la Salud (OMS). La COVID 19 es una infección que produce un síndrome respiratorio agudo severo que se ha caracterizado por fiebre, síntomas respiratorios y gastrointestinales, así como otras manifestaciones sistémicas. En este contexto, se han ido reportando manifestaciones clínicas en pacientes con SARS-CoV-2 positivos que han ido enriqueciendo el conocimiento sobre las características del cuadro clínico, sin embargo, uno de los aspectos escasamente documentados es la semiología a nivel de la cavidad oral. Nuevas evidencias muestran la relevancia de la cavidad oral como un reservorio del virus por lo que desempeña un papel fundamental en el diagnóstico, evolución y transmisión epidemiológica de los patrones de infección del COVID-19. El objetivo del presente es realizar una revisión y análisis de las evidencias disponibles en referencia a las manifestaciones orales en el contexto de la infección de SARS-CoV-2.

ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the host cells depends on the expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). We investigated the distribution of ACE2- and TMPRSS2-expressing cells in various oral tissues to identify the underlying mechanism of oral manifestations in patients with coronavirus disease 2019. We analyzed the expression patterns of ACE2 and TMPRSS2 in the oral mucosa (tongue, palate, and buccal mucosa), trigeminal ganglion, vessels, and salivary glands of 9 Sprague-Dawley rats using immunohistochemistry and immunofluorescence. ACE2 and TMPRSS2 were strongly expressed in the intermediate layer of the squamous epithelia of tongue papillae and buccal mucosa. ACE2- and TMPRSS2-positive cells were observed in the taste buds of the tongue. Additionally, ACE2 and TMPRSS2 were co-expressed in the ductal epithelium and acinar cells of salivary glands. Furthermore, both ACE2 and TMPRSS2 were stained in the neuronal cell body of trigeminal ganglia, but not in Schwann cells. Moreover, ACE2 and TMPRSS2 were expressed in capillaries, but not in venules/arterioles. SARS-CoV-2 can spread the suprabasal area of squamous epithelia of the oral mucosa, invades taste bud, trigeminal nerve, parotid gland, and microvessel, resulting in oral manifestations.

TASTE DISORDERS AND XEROSTOMIA ARE HIGHLY PREVALENT IN PATIENTS WITH COVID-19.

Article Title and Bibliographic InformationJ. Amorim dos Santos, A.G.C. Normando, R.L.Carvalho da Silva, A.C. Acevedo G. De Luca Canto, N. Sugaya, A.R. Santos-Silva , E.N.S. Guerra (2021). ``Oral Manifestations in Patients with COVID-19: A Living Systematic Review.'' J Dent Res 100(2): 141-154.Source of FundingNon-profit, Foundations, etc.? National Council for Scientific and Technological Development, Ministry of Education, Brazil and the Department of Research and Innovation, University of Brasilia, Brazil.Type of Study/DesignSystematic review with meta-analysis of data.

Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study

Background: Several systemic diseases manifest themselves in the oral cavity. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: The present cross-sectional study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr El Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Patients’ medical records were evaluated. The oral manifestations were assessed according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in SLE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with SLE as the WHO considers oral manifestations of SLE a widespread state. Also, the implementation of oral hygiene measures to improve patients’ nutritional state and health-related quality of life is recommended.

Oral manifestations in patients with Covid-19 – literature review

Oral manifestations in patients with Covid-19 – literature review

P050 Oral Inflammatory Changes Associated With Inflammatory Bowel Disease in Spondyloarthritis Associated With Early Endoscopic Findings.

Spondyloarthritis (SpA) is a heterogeneous group of chronic autoinflammatory disorders that can present extra-articular gastrointestinal manifestations. Among them is mainly inflammatory bowel disease (IBD). Although IBD mainly affects the intestinal tract, it can include early manifestations evident in the oral cavity. No comparative data on these oral manifestations in patients with SpA were found in the literature. To identify oral clinical manifestations due to changes in the oral mucosa associated with IBD in patients with SpA without a diagnosis of IBD and associate them with endoscopic and histological findings. 80 patients with SpA and 52 healthy controls were evaluated. They were assessed intra- and extra-orally, following the modified World Health Organization guideline. In addition, by clinical parameters of rheumatological, gastrointestinal and laboratory activity. Ileocolonoscopy was performed with digital chromoendoscopy with magnification and histological analysis. Comparative analyzes were performed by Chi square tests, Fisher's exact tests, confirmed by univariate regression and discriminant analysis of multiple correspondences. Institutional ethics committee approval cod-2017-023. The patients with SpA had 56% male gender, mean age of 42.8 years (SD ± 10.4) and a BMI in the range of 23.9 - 28.4. The healthy controls, 54% of the male gender with an average age of 41 years (SD ± 13.6) and a body mass index-BMI in the range of 22.9 - 27.6. The patients reported smoking only in 6.2%, however as a smoking history in 31% and passive smokers (15%), the majority employed (41%), married (56%) and professionals (49%). Of the healthy controls, they smoked (15%), with a history of smoking (31%), passive smokers (21%), the majority employed (77%), with their own home (67%), and professionals (54%). The patients with SpA reported a greater presence of some signs and symptoms of gastrointestinal origin 69%, while in the controls it was 7.7% (p = 0.001). Forty one of them were referred to colonoscopy with magnification being in 17.1 % changes in the mucosa of the rectum and in the same frequency changes in the mucosa of the sigmoid colon. Regarding the ileum, changes in the mucosa were evidenced in 41.5% of the cases. The presence of oral lesions was evident and predominated in them (63%) compared to controls p = 0.050. The main oral lesions associated with IBD were gingivitis (55%) (p = 0.001), followed by aphthous stomatitis (3.8%), angular cheilitis (2.6%) and perioral erythema with scaling (1.3%). 100% of the patients who presented alteration of the colonic mucosa presented oral lesions associated with IBD (p = 0039), which was also significantly associated with the presence of gingivitis/aphthous stomatitis (p = 0.029). Patients with SpA without a diagnosis of IBD have more oral signs and symptoms compared to healthy controls. Gingivitis is important given its association with early endoscopic and histological findings. Manifestations in the oral cavity can precede intestinal manifestations, therefore the clinical assessment by the oral pathologist in conjunction with gastroenterology and rheumatology allows a timely referral to gastroenterology and an endoscopic and histological evaluation, impacting the quality of life of patients.

Manifestaciones orales asociadas a SARS-COV-2: Revisión de la literatura

Objective: Identify the main oral manifestations associated with COVID19 and describe their location in the oral cavity. Methods: The literature search was conducted in PubMed, Medline, LILACS, LIVIVO, Web of Science, and SciELO. The following words were searched for: oral mucosa, oral mucosa lesion, oral manifestations, COVID-19, and SARS-CoV-2.&nbsp; Duplicate articles were eliminated, and the pieces were shortlisted. Finally, inclusion and exclusion criteria were applied. Results: This study included 47 articles. The main oral manifestations in patients with COVID-19 are taste disorders, xerostomia, ulcers, vesicles, and others located in different areas of the oral mucosa. Conclusions More studies are needed to determine the potential oral etiopathogenesis of SARS-CoV-2. Moreover, dentists play a significant role in the multidisciplinary and telemedicine team.

Impact of inhalation therapy on occurrence of oral manifestations in patients with bronchial asthma, in Jeddah, Saudi Arabia

Background: Inhalation therapy for asthma includes cortisol and bronchodilators. High dosage and long duration of inhalation therapy has been linked with several adverse effects on the oral tissues. Objectives: To explore the oral manifestations associated with the use of inhalation therapy among patients with asthma in Jeddah city. Method: This was a cross sectional study; the non-probability convenient sampling method was used to select 215 subjects (99 with Doctor diagnosed asthma and 116 without asthma), from the outpatient clinics of two private hospitals. Data were collected using interview questionnaire, the standard 5th ed. WHO survey on oral manifestations, measurement of vital signs and anthropometric parameters, as well as clinical oral examination. Data were analyzed using SPSS version 22, and Logistic multinomial regression was used to study the Odds ratio and its 95% confidence interval between the variables. Level of significance for the study was 0.05. Results: The majority of patients with asthma (95%) used inhalation therapy, without use of spacers. Ulceration, pigmentation and candidiasis of the tongue, buccal mucosa and palate weresignificantly more encountered among patients with asthma compared to those without asthma (p &lt; 0.001, 0.002 and 0.046 respectively). Xerostomia and salivary gland affection, also, were significantly more encountered among patients with asthma compared to those without asthma (p &lt; 0.000, and 0.002 respectively). Patients with asthma were 7.7 times more likely to develop tongue disorders (OR: 7.7, p &lt; 0.013), 3 times more likely to develop buccal mucosal disorders (OR: 3, p &lt; 0.039), and 15 times more likely to develop palate disorders (OR: 15, p &lt; 0.004) compared to subjects without bronchial asthma. Conclusion: Use of inhalation therapy in patients with asthma was significantly associated with increased occurrence of oral health problems. Health education programs about proper use of inhalers and oral hygiene should be implemented by primary health care personnel. Key words: Inhalation therapy, Asthma, Oral manifestations, Jeddah.

Oral manifestations in patients with COVID-19

The severe acute respiratory syndrome type 2 coronavirus (SARS-Cov-2) the causative agent of COVID-19, is found in saliva in a large percentage and saliva plays an important role as a transmitter of SARS-Cov-2 infection. Therefore, the oral cavity could be a reservoir for SARS-Cov-2 virus due to the hight affinity of this virus for cells with receptors for angiotensin-converting enzyme (ACE 2) and sialic acid, thus affecting the functioning of the salivary glands, taste sensations, smell and the integrity of the muco oral. Clinical manifestations have been reported among signs and symtoms that have contributed to understand the behavior of this SARS- Cov-2 virus; of wich dysgeusia, ageusia, hipogeusia and dry mouth have been reported in a large percentage among the main oral manifestation; however, there is a lack of information regarding oral manifestations in patients with COVID-19. The aim of this review is to identify the possible oral manifestations in patients with COVID-19 by compiling the information and presenting an uptaded presentation of the literature.

Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study

Background: Several systemic diseases manifest themselves in the oral cavity. Oral manifestations of lupus erythematosus (LE) are associated with a significantly increased risk of cancer. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: A descriptive study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr EL Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Moreover, patients' medical records were also evaluated. The oral manifestations were recorded according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in LE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. 74.3% of the patients had oral candidiasis. The prevalence of skin lesions in LE patients was 37.6%. The most common finding was malar rash 79%. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with LE as the WHO considers oral manifestations of LE a widespread state associated with an increased risk of cancer. Also, implementation of oral hygiene measures and treatment to improve patients' nutritional state and health-related quality of life are recommended.

An integrative review of oral manifestations in patients with COVID-19: signs directly related to SARS-CoV-2 infection or secondary findings?

We conducted an integrative review on oral manifestations in patients with COVID‐19 based on the current available literature evidence. A bibliographic search was carried out on March 11, 2021, among published studies in the years 2019–2021 in the PubMed database and based on the search strategy (“COVID‐19” AND “oral lesions” OR “oral mucositis” OR “oral manifestation”). After applying the inclusion and exclusion criteria, 29 articles were considered suitable for this review. A total of 110 cases of patients with COVID‐19 who had oral manifestations were reported. The presence of ulcerated lesions was the most common finding, having a herpetiform and aphthous clinical pattern observed in most cases. Macules, petechiae, hemorrhagic blisters, pustular enanthem, mucositis, and halitosis were also among the most frequently described oral manifestations. The tongue was the most commonly affected site, followed by the palate and lip. Most of the reported cases were diagnosed only by the clinical aspect of the lesion associated with a positive SARS‐CoV‐2 test or the presence of other COVID‐19 symptoms. Current scientific evidence still could not affirm that most of the oral lesions observed in patients with COVID‐19 are related to the virus's direct or indirect action on the oral mucosa. To confirm this association, prospective and longitudinal studies are further needed, together with a larger number of patients, complemented by histopathological examination of these lesions. Additionally, molecular techniques, such as immunohistochemistry and in situ hybridization, may be necessary to perform the differential diagnosis with other oral lesions.

Critical oral diseases in rheumatoid arthritis: knowing, understanding and preventing / Lesões bucais importantes na artrite reumatoide: conhecer, compreender e prevenir

Rheumatoid Arthritis (RA) is a chronic multifactorial disease characterized by inflammation of the synovial membranes that line the joints and affect 1% of the world population. This narrative review aims to discuss a highlight mechanisms about the main oral manifestations in patients with rheumatoid arthritis researching epidemiological data. This narrative review was performed by searching the literature on the MEDLINE / PubMed databases for articles in English focused on oral diseases in patients with RA. Scientific studies show that RA patients are at high risk of developing oral changes, for example, periodontal disease (PD), Sjögren's syndrome (SS), xerostomia and temporomandibular joint disorder (TMD). There is a complex interrelation between oral diseases and RA, with sufficient scientific evidence to assure that there is an association that is bidirectional and impacts the pathogenesis and evolution of these conditions. This bidirectional connection with effects on the inflammatory profile of individuals reinforces the need for future clinical studies that confirm the effectiveness of prevention and early diagnosis protocols for rheumatological disease and the main associated oral diseases.

Acute Oral Manifestations in Patients Submitted to Radiotherapy in the Head and Neck Region: Literature Narrative Review

AbstractThe use of ionizing radiation, affects not only malignant cells but also healthy tissues, and promotes several side acute or late effects in the oral cavity. Among the acute effects, oral mucositis, xerostomia, hyposalivation, dysgeusia and dysphagia present a prominent role. The present study aims to conduct a narrative literature review on radiotherapy in the head and neck region as a therapeutic modality for cancer in this region and the main acute oral manifestations and their respective treatments. This was an exploratory literature review, through the database of Scielo, Pubmed, Medline and institutional websites using the crossing of the descriptors in English and Portuguese “head and neck neoplasms”, “radiotherapy”, “xerostomia”, “dysgeusia” and “dysphagia”. According to the established criteria, a total of 46 articles and 2 institutional websites were selected from the databases, and one book was added for presenting relevance on this theme. The results demonstrate that oral mucositis is the most prevalent acute effect and has a direct impact on patient’s quality of life, but there is no gold standard treatment. Dysphagia, xerostomia, hyposalivation and dysgeusia are common manifestations in irradiated patients, and present several therapeutic modalities. Given the importance of side effects of radiotherapy in head and neck region, further studies are needed to widely disseminate acute oral manifestations in irradiated patients. Keywords: Oral Mucositis. Head and Neck Neoplasms. Radiotherapy. Xerostomia. ResumoA utilização de radiação ionizante, no câncer de cabeça e pescoço, afeta não somente células malignas, mas também tecidos sadios, o que promove diversos efeitos colaterais em cavidade oral, classificados em agudos ou tardios. Dentre os efeitos agudos, a mucosite oral, xerostomia, hipossalivação, disgeusia e disfagia apresentam papel de destaque. O presente trabalho visou realizar uma revisão narrativa de literatura sobre a radioterapia em região de cabeça e pescoço como modalidade terapêutica para o câncer nesta região e as principais manifestações orais agudas decorrentes da radiação ionizante e seus respectivos tratamentos. Tratou-se de revisão de literatura do tipo exploratória, através das bases de dados da Scielo, Pubmed, Medline e sites institucionais utilizando o cruzamento dos descritores em inglês e português “neoplasias de cabeça e pescoço”, “radioterapia”, “mucosite oral”, “xerostomia”, “disgeusia” e “disfagia”. De acordo com os critérios estabelecidos, um total de 46 artigos e 2 sites institucionais foram selecionados nas bases de dados, e 1 livro foi acrescentado por apresentar relevância sobre a temática em questão. Os resultados demonstram que a mucosite oral é o efeito agudo mais prevalente e apesar de ter impacto direto na qualidade de vida, não há tratamento considerado padrão ouro para esta condição. A disfagia, xerostomia, hipossalivação e disgeusia são manifestações comuns em pacientes irradiados, e apresentam diversas modalidades terapêuticas que podem ser empregadas. Dada à importância dos efeitos colaterais da radioterapia de cabeça e pescoço, torna-se necessária a realização de mais estudos afim de divulgar amplamente as manifestações orais agudas em pacientes irradiados. Palavras-chave: Mucosite Oral. Neoplasias de Cabeça e Pescoço. Radioterapia. Xerostomia

Oral manifestations of patients with COVID- 19 infection

COVID- 19 is a horrifying pandemic which affected all countries with significant involvement of population leaving the whole world helpless and in distress and grief. Scientists in the entire universe are working to get the healing solution to get rid of this terrific Corona Virus. Though vaccination against this infection has provided an apt relief but still the fight is on against the developing mutant stains. Numerous positive Covid cases have been presented with varied oral manifestations, which are important for dental surgeons to comprehend. The present review article highlighted oral lesions in patients with COVID- 19 disease.