Oral Manifestations In Patients Research Articles

Chronic nonspecific cheilitis associated with tislelizumab treatment in a patient with a history of tongue squamous cell carcinoma: a case report

BackgroundChronic nonspecific cheilitis is a complex condition characterized by persistent lip peeling and discomfort. This case report explores the clinical progression of a patient with history of tongue squamous cell carcinoma and subsequent Tislelizumab treatment, presenting with persistent lip peeling.Case presentationA patient with a history of tongue squamous cell carcinoma (T2N0M0), treated with chemotherapy, surgery, and Tislelizumab, presented with six months of persistent lip peeling. Clinical examination revealed distinct features of chronic nonspecific cheilitis with infectious angular cheilitis (Oral Candidiasis). A tailored treatment plan, emphasizing oral hygiene practices and local treatments with Sodium Bicarbonate, Tacrolimus ointment, and Chlortetracycline ointment. Follow-up visits demonstrated sustained improvement, highlighting the significance of individualized approaches.ConclusionsThis case underscores the importance of recognizing and managing oral manifestations in patients with a history of cancer and immunotherapy. The patient’s response to treatment suggests that a multifaceted approach, combining local therapy with lifestyle modifications, can be effective in managing chronic nonspecific cheilitis associated with immunotherapy. Routine follow-up appointments, guided by personalized medicine principles, contribute to sustained patient well-being.

Assessment of studies on oral manifestations and COVID-19

Aim: This study aimed to evaluate how different study designs influences the presence and characteristics of diagnosis of oral manifestations in patients with COVID-19. Methods: This study is a meta-search conducted with studies evaluating the relationship between patients with oral manifestations and COVID-19. A search was conducted in three databases (PubMed, Web of Science, and Scopus), using terms specific to COVID-19 and oral lesions, including only primary studies. Study selection was undertaken by two reviewers independently. A descriptive analysis was performed. Results: The results included 55 studies in the data synthesis analysis. Most of the studies were case reports and case series. Some of the studies did not relate a biological test to confirm COVID-19. The ulcer lesion and that clinical examination by specialists were the most reported lesion in case reports and case series studies, while taste alterations and patient self-report were more reported in observational studies. Conclusions: This review concluded that the oral lesions in patients with COVID-19 differ according to the study design. The lack of high-quality scientific evidence in the dental literature on COVID-19 makes the findings inconsistent by the lack of sample selection criteria, diagnostic criteria and classification of oral lesions.

ORAL MANIFESTATIONS IN PATIENTS WITH DIABETES MELLITUS. REVIEW LITERATURE

Background: Diabetes mellitus causes a number of complications in various regions of the body including the oral cavity, the type and degree of which depends on the duration of the disease, its severity, and the age of the patient. Objective: The aim of this literature review was to summarize Oral manifestations in patients with diabetes mellitus. Methods: Search strategy was applied with the aim of identifying as many relevant publications as possible. Data Sources four electronic databases were searched: PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials. The key words used for the search were Diabetes mellitus, Oral complications in Diabetes, Oral manifestations, Periodontal disease, Xerostomia. Of the 146 studies identified, a total of 67 articles that met the inclusion criteria for this systematic review were included. Results: The results of a systematic review showed that oral manifestations and complications in patients with diabetes mellitus are one of the main complications of diabetes mellitus. There is more evidence that chronic oral complications in patients with diabetes negatively affect blood glucose control. Oral complications include many complications that patients with diabetes suffer from, including caries teeth, painful gingival swelling, periodontal disease and mobility of teeth, oral infections, salivary gland dysfunction, taste dysfunction, tongue abnormalities, bad breath and lichen planus. Knowledge of the characteristic clinical changes in oral tissues caused by diabetes mellitus helps medical professionals diagnose and treat diabetes. Conclusion: Prevention and treatment of complications with aspects of the oral cavity, especially periodontal disease, are important in patients with diabetes because of their possible adverse effects on glycemic control. Restoring sugar metabolism by correcting insulin deficiency can control diabetes mellitus. Promoting for healthy oral cavity for patients with diabetes mellitus is of paramount importance

Oral symptoms potentially associated with mild-to-moderate COVID-19 in tobacco users.

Coronavirus disease (COVID-19) is a worldwide infection characterized by various symptoms. Few studies have examined its oral manifestations. However, there is insufficient information on the oral manifestations of patients with COVID-19 who use tobacco products. Therefore, this cross-sectional study investigated oral symptoms of tobacco-using patients with mild-to-moderate COVID-19. This study used a convenience sample of non-hospitalized patients (aged ≥18 years) with mild-to-moderate COVID-19 diagnosed by polymerized chain reaction (PCR). This study excluded pregnant or lactating women or patients with serious COVID-19 complications, including those who required hospitalization or were on specific medications (antiviral, corticosteroid, antimicrobial, or immunosuppressive). Oral examinations were performed, including labial, buccal, and gingival mucosa, tongue, floor of the mouth, and palate, for any newly developed lesions associated with the onset of COVID-19. The salivary flow was determined using the passive drool collection technique. Lip dryness, gingivitis, tongue lesions, and taste loss were the most commonly reported oral symptoms in patients with mild-to-moderate COVID-19. The most common general symptoms were tiredness and headache (63.9%), followed by dry cough, myalgia, sore throat, and fever. This study found 139 occurrences of oral symptoms, of which 52 were dry lips (27 tobacco non-users, and 25 tobacco users), and 11 were gingivitis (five non-users, and six tobacco users), and 12 tongue changes (eight non-users, and four tobacco users). Ageusia, or loss of taste sensation, was most commonly reported with or without other oral COVID-19 symptoms (55 occurrences: 36 non-users and 19 tobacco users). No significant differences were found in oral symptoms between tobacco non-users and tobacco users. There is a need to expand the routine examination protocol for patients during future respiratory pandemics, as monitoring oral health allows dentists to improve the management of oral sequelae during a pandemic.

Common Oral Manifestations in a Denture Wearer Patients with Suspected Diabetes Mellitus

Background. Acute pseudomembranous candidiasis or often called oral thrush is a disease in the oral cavity caused by the overgrowth of Candida albicans. Angular cheilitis is an inflammatory lesion on the corners of the mouth. The purpose of this case report is to document the oral manifestations in patients with suspected diabetes mellitus. Case Report. A 57-year-old woman came with complaints of a burning sensation throughout the mouth and lips and presented a white spot on her tongue with soreness in the past year. The patient has diabetes mellitus and regularly takes medication. Despite this, the patient still has experienced classical signs of diabetes mellitus which are polyphagia, polydipsia, and polyuria. Intraorally the burning sensations were related to the full denture continuous wearness and were diagnosed as acute pseudomembranous candidiasis and angular cheilitis. The treatment given to this patient was symptomatic therapy in the form of Aloclair Plus mouthwash, causative therapy in the form of Nystatin oral suspension and referral to an internist to further examine the condition of diabetes mellitus, and supportive therapy in the form of lanolin and vaseline. Treatment ends with the provision of communication, instruction, and education.

Premenstrual Syndrome: Awareness and Oral Manifestations in Patients Attending Dental Hospital in Pune

ABSTRACT Fluctuations in androgenic hormonal levels are noticeable through women’s menstrual cycle. Changes in estrogen and progesterone have been shown to affect periodontium. Many women report an increase in gingival inflammation and discomfort associated with their menstrual cycle, most commonly before the menstrual period. Approximately 80% of women experience complaints of premenstrual syndrome (PMS) 7 to 10 days before menstruation. Therefore, the present study was carried out to check prevalence of PMS and its oral and periodontal manifestations in patients attending dental hospital. For the study, 100 systemically healthy women of reproductive age attending dental hospital were selected. Thorough recording of oral discomfort and associated symptoms during late luteal phase was done. Clinical parameters such as plaque index and gingival index were recorded.Thirty-seven females reported complaints suggestive of PMS. Oral changes during PMS were experienced by 59 females. Halitosis and oral ulcers were more frequent. Findings of the present study showed the possibility of influence of sex hormones on oral manifestations during premenstrual period.

Oral Mucosal Manifestations Associated with PCR Positivity in Patients with COVID-19.

To date various oral manifestations in patients with coronavirus disease 2019 (COVID-19) have been reported. In the present study, we investigated the relationship between Polymerase Chain Reaction (PCR) positivity and oral signs in patients with suspected COVID-19. A total of 383 patients who presented to the emergency department for the first time with any symptoms associated with COVID-19 were included in the study. Oral examinations were performed and the findings, PCR status, and thorax computerized tomography (CT) reports were recorded. Oral mucosa was involved in 246 (64.2%) patients. 175 (78,4%) of patients with COVID-19 confirmed the diagnosis with PCR test or CT results had oral manifestation. Dry mouth, microvesicles on the tonsils or pharynx, and petechiae in the oropharynx were significantly higher in patients with positive PCR tests (P = 0.001, P < 0.001, P < 0.001, respectively). The ratio of intact oral mucosa was statistically significantly higher in patients with negative PCR tests compared to those with positive PCR tests (P < 0.001). Microvesicles on the tonsils or pharynx were most associated with PCR positivity in patients without lung involvement (P < 0.001). Dry mouth, erythema of the tonsils and pharynx, petechiae in the oropharynx, and primary/secondary herpes infection are more related to PCR positivity in patients without lung involvement (P < 0.05). Lung involvement in patients with PCR positivity is related to only cheilitis (P = 0.034). Our study revealed that especially microvesicles, petechiae, erythema on the tonsils or pharynx, and some other oral lesions such as dry mouth, oral aphthae, and primary/secondary herpes infection are associated with PCR positivity.

P451 Specific Oral Manifestations in Patients with Crohn's Disease

Abstract Background Extra-intestinal manifestations of Crohn's disease (CD), including arthropathic, mucocutaneous, ophthalmic and hepatobiliary disorders, have a prevalence ranging from 16.7% to 40%. Oral manifestations of CD are classified into specific manifestations directly related to intestinal inflammation and non-specific manifestations. The aim of this study was to determine the frequency and characteristics of specific oral manifestations in patients with CD. Methods We retrospectively evaluated 676 patients with CD who were followed up for at least 6 months between June 2013 and February 2023 at our tertiary care center. Specific oral lesions were clinically defined as cobblestoning, orofacial granulomatosis, lip/cheek swelling with fissuring, and pyostomatitis vegetans. Confirmation of specific lesions was made by experienced dentists for each case. Results Of the 676 CD patients (58.9% male, median age 38 years) followed for 6.83 years (IQR 3.45-11.76 years), 96 (14.2%) had oral lesions. Specific oral lesions were found in 8 patients (1.2%), while 88 (13.1%) had non-specific lesions. The specific lesions included cobblestoning (n=2), orofacial granulomatosis (n=3), glossitis with fissuring (n=2), and lip swelling with fissuring (n=2). Patients with specific lesions were predominantly male (75%) with a median age of 46.5 years (range 23-68 years). Disease location was ileal (25%), colonic (25%), and ileocolonic (50%), with perianal disease in 50%. Disease behavior was inflammatory in 7 and penetrating in 1 patient. Three patients were active smokers. Three patients had prior major abdominal surgery. Concurrent extraintestinal manifestations included peripheral arthritis/arthralgia (n=7), sacroiliitis (n=1), and uveitis (n=2). Immunomodulators were used in 7 patients and biologics in 5 patients. All specific lesions were associated with active disease (median CRP 35.5 mg/L, range 6-151 mg/L; median CDAI 313, range 227-480) and improved with immunomodulator or biologic therapy. Conclusion In this large cohort of CD patients, the frequency of specific oral manifestations was 1.2%. These lesions were associated with active disease and improved with immunosuppressive treatment, highlighting the need for close collaboration between gastroenterologists and dentists for early recognition and optimal management.

Oral Manifestations of Patients with Chronic Kidney Diseases: A Cross-Sectional Study

Oral Manifestations of Patients with Chronic Kidney Diseases: A Cross-Sectional Study

Considerations of Nystatin Roll in Oral Candidiasis Scenario and the COVID-19 Pandemic—A Review

Oral candidiasis is an opportunistic infection usually related to predisposing factors. Oral manifestations in patients affected by COVID-19 have been reported, as the oral mucosa is the gateway to this viral infection. Xerostomia, as well as other oral symptoms, are predisposing factors for the emergence of oral candidiasis after the COVID-19 pandemic. It is a common pathology, but fatal if left untreated. Nystatin (NYS) is the drug of first choice in the treatment of oral candidiasis. Herein, we reviewed the epidemiology of oral candidiasis and its treatments, focusing on the mechanism of action, dosage forms, and NYS efficacy. NYS is an effective drug against oral candidiasis and belongs to Class IV of the biopharmaceutical classification system; however, its low solubility and low permeability may compromise its availability in the oral cavity and, consequently, its pharmacological action. Future perspectives to overcome drug limitations were also addressed and discussed in our review.

Oral manifestations in patients with coronavirus disease 2019 (COVID-19) identified using text mining: an observational study

Text mining enables search, extraction, categorisation and information visualisation. This study aimed to identify oral manifestations in patients with COVID-19 using text mining to facilitate extracting relevant clinical information from a large set of publications. A list of publications from the open-access COVID-19 Open Research Dataset was downloaded using keywords related to oral health and dentistry. A total of 694,366 documents were retrieved. Filtering the articles using text mining yielded 1,554 oral health/dentistry papers. The list of articles was classified into five topics after applying a Latent Dirichlet Allocation (LDA) model. This classification was compared to the author's classification which yielded 17 categories. After a full-text review of articles in the category “Oral manifestations in patients with COVID-19”, eight papers were selected to extract data. The most frequent oral manifestations were xerostomia (n = 405, 17.8%) and mouth pain or swelling (n = 289, 12.7%). These oral manifestations in patients with COVID-19 must be considered with other symptoms to diminish the risk of dentist-patient infection.

Oral Manifestations of Crohn's Disease: A Systematic Review.

Crohn's disease (CD) is a chronic inflammatory intestinal condition that can affect the entire gastrointestinal tract. It is characterized by its clinical heterogeneity and irregularities in its course. The etiology and pathogenesis are not well established, so it is difficult to establish an early diagnosis and an effective treatment plan. The objective of this systematic review was to present a qualitative synthesis of the studies referring to the oral manifestations of CD. This systematic review was carried out following the PRISMA guide. Research was conducted in the Pubmed, Web of Science, Scopus, Scielo, and Cocrahne Library databases on 23 February 2023, and updated on 1 September 2023. Articles published between 2012 and 2023 were selected. Articles that analyzed the oral manifestation of CD patients and met the established search terms. In addition, the quality of all the selected studies was analyzed following the CARE guidelines for case reports and the STROBE scale for observational studies. A total of 19 articles were included in this review that met the inclusion criteria. Regarding the oral manifestation of CD, oral ulcers, angular cheilitis, and gingivitis stand out. Periodontitis and vegetative pyostomatitis were the least representative manifestations. The most prevalent locations were lips, mucosa, and gingivae. Ulcers, gingivitis, and angular cheilitis are the most frequent oral manifestations in patients with CD. Their early identification and possible relationship with the disease are important for an early diagnosis and an adequate treatment plan.

POSTER: AML-233 Incidence of Oral Manifestations in Patients With Hematological Malignancy

POSTER: AML-233 Incidence of Oral Manifestations in Patients With Hematological Malignancy

AML-233 Incidence of Oral Manifestations in Patients With Hematological Malignancy

AML-233 Incidence of Oral Manifestations in Patients With Hematological Malignancy

The Relevant Oral Burden of Patients with Hidradenitis Suppurativa.

Interleukin-17 plays a pivotal role in both hidradenitis suppurativa (HS) and in maintaining oral homeostasis, but their potential link remains unknown. Thus, we aimed to evaluate and quantify the oral burden of patients with HS. In this real-life, multicenter, cross-sectional study, patients with HS were clinically evaluated by two board-certified dermatologists and two board-certified dentists. Oral comorbidities were carefully collected with medical history and therapeutic information. A total of 102 patients (44.0 ± 0.9years, body mass index 27.0 ± 2.2kg/m2) were enrolled. Remarkably, 48% and 43% did not undergo at least an oral hygiene or a dental visit each year, respectively. Oral disorders were found in 55.9% of patients with HS, in particular 39.2% had caries and 46.7% reported at least one missing tooth. The main oral manifestations in patients with HS were recurrent aphthous stomatitis (N = 19, 19.2%), amalgam tattoo (N = 14, 14.1%), leukoplakia (N = 11, 11.1%), nicotinic stomatitis (N = 9, 9.1%), papilloma (N = 8, 8.1%), and geographic tongue (N = 8, 8.1%). Whilst the main predictor of oral pathological conditions was Hurley staging (P = 0.0276), multivariate regression analysis indicated that gender and International Hidradenitis Suppurativa Severity Score System (IHS4) were the main predictors for the presence of caries and number of missing teeth. As a result of the relevant oral burden in patients with HS, dentists should be part of the multidisciplinary team and oral education should be promoted among patients with HS.

Beyond the Gut: A Systematic Review of Oral Manifestations in Celiac Disease.

Celiac disease (CD) is a chronic immune-mediated gluten-sensitive enteropathy, affecting about 1% of the population. The most common symptoms include diarrhea, abdominal pain, weight loss, and malabsorption. Extra-intestinal symptoms include oral manifestations. This systematic review aims to catalog and characterize oral manifestations in patients with CD. a systematic literature review among different search engines using PICOS criteria has been performed. The studies included used the following criteria: tissues and anatomical structures of the oral cavity in humans, published in English and available in full text. Review articles and papers published before 1990 were excluded. 209 articles were identified in the initial search. In the end, 33 articles met the selection criteria. The information extracted from the articles was classified based on the type of oral manifestation. Recurrent aphthous stomatitis (34.6%), atrophic glossitis and geographic tongue (15.26%), enamel defects (42.47%), delayed dental eruption (47.34%), xerostomia (38.05%), glossodynia (14.38%), and other manifestations including cheilitis, fissured tongue, periodontal diseases, and oral lichen planus were found in the celiac subjects of the studies analyzed. The quality of articles on the topic should be improved; however, oral manifestations in CD patients are widely described in the literature and could help diagnose celiac disease.

Oral Manifestations in Patients with Gastro-Esophageal Reflux Disease

Aim: To analyze the occurrence and correlation of oral manifestations of patients affected by gastro-esophageal reflux disease (GERD), especially with dental erosion. Materials and Methods: With a simple randomization method, a total of 120 patients, GERD-diagnosed patients (group 1, n = 60), based on complaints and reviewed by gastroenterologists through proper history, clinical pictures, and established investigations, and healthy individuals (group 2, n = 60), were enrolled in the study. Oral manifestations such as xerostomia, oral acid/burning sensation, subjective halitosis, dental sensitivity, and dental erosion were evaluated in both groups. The Chi-square test and continuous variables were compared by the Mann–Whitney test and the Kruskal–Wallis test (P value &lt; 0.05, significant). Results: The Mann–Whitney U test on the distribution of the gastric complaints between two groups revealed a significant difference in all the variables. A significant difference was found in the distribution of all the oral manifestations except halitosis and dentinal hypersensitivity between both groups. The Chi-square test between the heartburn and dental erosions revealed a significant association (c2 = 293.761, df = 1, P &lt; 0.001), whereas there was no significant association between heartburn and dentinal hypersensitivity. Conclusion: GERD and dental erosions had no significant correlation, whereas other oral manifestations and mucosal changes were found significant with GERD.

AN UPDATE ON ORAL MANIFESTATIONS OF SARS COV-2 INFECTION AND SURVIVAL OUTCOME OF PATIENTS WITH MUCORMYCOSIS : A SYSTEMATIC REVIEW AND META-ANALYSIS.

The coronavirus disease (COVID-19) outbreak caused by SARS-CoV-2 is a pandemic infectious disease threatening the world that has been emerged by human-to-human transmission through respiratory droplets. However, the Angiotensin converting enzyme 2 (ACE2) receptor is also considered as the main functional receptor through which SARS CoV-2 gains entry into the body. Now-a-days mucormycosis incidence is increased rapidly due to severe effect of COVID-19 on patient's immune response. Mucormycosis is a rare invasive fungal disease often seen in immunocompromised individuals, mainly in patients with diabetic ketoacidosis, and in patients at concomitant use of steroids. As the prevalence of oral manifestations in effected individuals are still unknown, it has become a broad and current interest. Therefore, this paper aims to summarize the updated literature on oral manifestations of patients with COVID-19 and to analyse the survival outcome of patients with mucormycosis during covid crisis.

Oral Manifestations of Patients Diagnosed with Dermatological Diseases: A Cross-Sectional Study in Eastern Province, KSA

Background: It is not unusual for oral manifestations to occur in dermatological diseases. The aim of this study was to observe and evaluate oral manifestations in patients diagnosed with dermatological diseases. Methods: A cross-sectional study based on a convenient sampling technique was conducted among patients with dermatological conditions who visited the polyclinic of King Faisal University Polyclinic of Al-Ahsa, Saudi Arabia from Sep-Nov 2021. Results: Sixty-one percent were females, 50% were aged &gt;30 years, 77% had higher education, 61% were unemployed, 82% were non-smokers, and 20% had some medical conditions. 14.5% suffered from immune-mediated skin disease, 25.3% had eczema, 21.7% showed dermatitis infections, 3.6% had Genodermatosis, 9.6% were with psoriasis and other keratinizing disorders, and 25.3% had miscellaneous skin conditions. 85.5% of skin patients did not have any oral manifestations; oral lesions were of perioral dermatitis (1.2%), melanotic macule (1.2%), fissured tongue (2.4%), oral lichen planus (2.4%), mucocele (2.4%), and one case of each with geographic tongue, herpes labialis, and hairy tongue. Practical ImplicationsThis study highlights the importance of integration of oral health into general health for management of oral diseases associated with other body diseases. Conclusion: The majority of the patients in this study sample with skin diseases did not show any oral manifestations. More females and aged patients had more skin conditions. Keywords: Prevalence, Oral manifestations, Dermatological conditions, Cross-sectional study

Breast Cancer Patients and their Orofacial Manifestation

Background and Objective: Surgery, chemotherapy, radiotherapy, and hormone therapy are the most commonly used methods for treating breast cancer, but these therapies, in turn, cause short and long-term side effects in such cases. This study aimed to investigate oral manifestations in patients undergoing breast cancer treatment. Method: In this cross-sectional study, the oral cavity of 101 patients admitted to a private clinic of hematology and oncology for the treatment of breast cancer in Shiraz were examined. Full oral examinations including mucosal and dental changes are recorded. Data were collected and analyzed using SPSS software version18. Results: The mean age of the participants (females) was 45.77±11.47 years old. 38 (37/6%) patients had distant metastases to other organs and 63 (62/4%) had no metastases. 48 (47.5%) patients specifically used chemotherapy and only 7 (6.9%) patients used radiotherapy. The most common oral complications were dry mouth (47.5%) and changes in taste (45.5%). The most common skin disorder was skin irritation with 13.8%, followed by herpes labialis with a 5% prevalence. Conclusion: Our results showed that oral findings such as xerostomia and taste changes were prevalent in the breast cancer patients undergoing radiotherapy, chemotherapy, and hormone therapy but skin complications like erythema, irritation, and herpes simplex infection are less frequent.