Oral Function Research Articles

Variational Autoencoders for Generative Drug-Gene Interactions in Periodontal Bone Resorption.

Introduction Periodontal bone resorption is a significant dental problem causing tooth loss and impaired oral function. It is influenced by factors such as bacterial plaque, genetic predisposition, smoking, systemic diseases, medications, hormonal changes, and poor oral hygiene. This condition disrupts bone remodeling, favoring resorptive processes. Variational autoencoders (VAEs) can learn the distribution of drug-gene interactions from existing data, identify potential drug targets, and predict therapeutic effects. This study investigates the generation of drug-gene interactions in periodontal bone resorption using VAEs. Methods A bone resorptive drugs dataset was retrieved from Probes and Drugs and analyzed using Cytoscape (https://cytoscape.org/) and CytoHubba (https://apps.cytoscape.org/apps/cytohubba), powerful tools for studying drug-gene interactions in bone resorption. The dataset was then prepared for matrix representation, with normalized input data. It was subsequently divided into training, validation, and testing sets. We then built an encoder-decoder network, defined a loss function, optimized parameters, and fine-tuned hyperparameters. Using VAEs, we generated new drug-gene interactions, assessed model performance, and visualized the latent space with reconstructed drug-gene interactions for further insights. Results The analysis revealed the top hub genes in drug-gene interactions, including Matrix Metalloproteinase (MMP) 14, MMP 9, HIF1A, STAT1, MAPT, CAS9, MMP2, CASP3, MMP1, and MAK1. The VAE's reconstruction accuracy was measured using mean squared error (MSE), with an average squared difference of 0.077. Additionally, the KL divergence value was 2.349, and the average reconstruction log-likelihood was -246. Conclusion The generative variational encoder model for drug-gene interactions in bone resorption demonstrates high accuracy and reliability in representing complex drug-gene relationships within this context.

Association between oral function and physical activity performance in older adults: a cross‑sectional study

Association between oral function and physical activity performance in older adults: a cross‑sectional study

SALIVARY BIOMARKERS OF DENTAL CARIES - A REVIEW ARTICLE

Saliva is the complex mixture of fluids that surrounds the oral tissues, secreted by the major and minor salivary glands1. Human saliva not only lubricates the oral tissues, making oral functions such as speaking, eating, and swallowing possible, but also protects teeth and oral mucosal surfaces in different ways. Dental caries is recognized as a multi-factorial infectious disease caused by complex interactions among acid-producing bacteria, fermentable carbohydrates and many host factors including saliva. Saliva is easy to collect, to store, and can be obtained at low cost in sufficient quantities for analysis by a non-invasive method. Thus it has the potential to be used in the early detection and diagnosis of various oral diseases due to the abundant biomarkers present in saliva. Saliva biomarkers such as salivary flow, salivary pH, salivary proteins, microorganisms etc, are used for the prediction, diagnosis, prognosis and management of dental caries, as well as for evaluating the outcome of therapeutic regimens. This article aims to providea brief overview of salivary biomarkers present which can be used for the early detection nd prevention of dental caries in humans.

Description of the Level of Knowledge About Dental and Oral Hygiene in Class XII of SMK Karya Adi Husada Mataram

Knowledge of dental and oral hygiene is very important in maintaining oral hygiene. Dental and oral hygiene is carried out to prevent dental and oral diseases, increase endurance, and improve oral function. Maintaining oral hygiene at school age is one way to improve health at an early age. This study aims to describe the level of knowledge about oral hygiene in class XII SMK Karya Adi Husada Mataram. The type of research used is descriptive survey research, which is a research method that takes a sample from a population and uses a questionnaire as a data collection tool to see the level of knowledge of dental and oral hygiene in Class XII SMK Karya Adi Husada Mataram. From the examination conducted at SMK Karya Adi Husada Mataram, it was found that the results of OHI-S scores on 30 students who had been examined were 3 students with good OHI-S scores, 10 students with moderate OHI-S scores, and 17 students whose OHI-S scores bad. The conclusion of this study is the level of knowledge about oral hygiene, the results can be obtained from the majority of respondents with moderate knowledge of 16 respondents.

Effects of various prosthetic methods for patients with Kennedy Class I partial edentulism on oral hypofunction, subjective symptoms, and oral health-related quality of life

PurposeThis propensity score matching, multicenter, cross-sectional study was performed to examine the effects of various prosthetic methods for dental clinic outpatients with Kennedy Class I partial edentulism (KCIPE) on oral hypofunction, subjective frailty symptoms, and oral health-related quality of life (QOL).MethodsPatients (n = 348) were classified into the following three groups for analysis: NT, patients with natural dentition providing intermaxillary contact in four occlusal supporting zones; RPD, patients with KCIPE who received removable partial dentures; and ISFP, patients with KCIPE who received implant-supported fixed prostheses. Participants' basic characteristics were recorded, and oral function tests were conducted. Subjective symptoms of physical and oral frailty were investigated via questionnaire. Oral health-related QOL was assessed using the Japanese short version of the Oral Health Impact Profile (OHIP-JP16). Propensity score matching was performed to adjust for patient background factors that could influence oral hypofunction in each group.ResultsCompared with the ISFP group, the RPD group had significantly higher rates of poor oral hygiene, reduced occlusal force, decreased masticatory function, and declines in swallowing function and oral hypofunction; the odds ratio for oral hypofunction was 4.67. Compared with the ISFP group, the RPD group had significantly greater subjective symptoms of physical frailty and oral frailty, as well as higher OHIP scores.ConclusionsProsthetic treatment of KCIPE affected oral hypofunction, subjective frailty symptoms, and oral health-related QOL in dental clinic outpatients.

Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile.

Single-domain antibodies (sdAbs), such as VHHs, are increasingly being developed for gastrointestinal (GI) applications against pathogens to strengthen gut health. However, what constitutes a suitable developability profile for applying these proteins in a gastrointestinal setting remains poorly explored. Here, we describe an in vitro methodology for the identification of sdAb derivatives, more specifically divalent VHH constructs, that displayextraordinary developability properties for oral delivery and functionality in the GI environment. We showcase this by developing a heterodivalent VHH construct that cross-inhibits the toxic activity of the glycosyltransferase domains (GTDs) from three different toxinotypes of cytotoxin B (TcdB) from lineages of Clostridium difficile. We show that the VHH construct possesseshigh stability and binding activity under gastric conditions, in the presence of bile salts, and at high temperatures. We suggest that the incorporation of early developability assessment could significantly aid in the efficient discovery of VHHs and related constructs fit for oral delivery and GI applications.

Decrease in Tongue Pressure in Frail Patients in the Sitting Position and Its Alleviation by Plantar Grounding.

The deterioration of oral function has received much attention, also being referred to as "Oral frailty". This study evaluated the change in tongue pressure, one of the objective items of oral frailty, to examine the relationship between body position and tongue pressure. This study was a prospective, observational study conducted in a single center. The participants were categorized by their Clinical Frailty Scale (CFS) scores. Tongue pressure was measured in the following positions: dorsal, sitting, and sitting with plantar grounding. Differences in tongue pressure between CFS and between body positions were statistically analyzed. A significant decrease in tongue pressure was demonstrated in CFS4 compared to CFS3. Furthermore, in CFS5 and CFS6, tongue pressure decreased in the sitting position compared to that in the dorsal position, and tongue pressure recovered to the dorsal level with plantar grounding. Tongue pressure decreased with the progression of frailty. It was decreased by sitting, and this decrease was alleviated by plantar grounding.

The Research Effect Of Chewing Function Nursing Techniques In Improving Swallowing Dysfunction Among Children With Cerebral Palsy

The objective of this study was to analyze the efficacy of chewing function nursing techniques in improving swallowing dysfunction among children with cerebral palsy. A total of 60 children with cerebral palsy and swallowing disorders, admitted to our hospital from January 2020 to December 2022, were included in the study. The children were randomly divided into an observation group and a control group using a random number table. The control group received routine rehabilitation nursing, while the observation group received additional nursing measures focusing on chewing function techniques in addition to the routine rehabilitation nursing. Both groups underwent interventions for a period of 3 months. Swallowing dysfunction, eating ability, and oral motor function were evaluated and compared between the two groups before and after treatment. Specifically, the Dysphagia Diet Scale (DDS) was used to assess swallowing dysfunction, the Eating and Drinking Ability Classification System (EDACS) was used to evaluate eating ability, and the Structured Oral Motor Assessment (SOMA) was used to assess oral motor function. The results showed that before rehabilitation nursing, there was no significant difference in DDS scores between the two groups. However, after rehabilitation nursing, both groups exhibited lower DDS scores compared to before, and the observation group had lower scores than the control group, indicating a significant difference (P < 0.05). Similarly, before rehabilitation nursing, there was no significant difference in EDACS ratings between the two groups. After rehabilitation nursing, both groups of children showed improvement in EDACS ratings, with the observation group demonstrating better outcomes than the control group. The difference between the two groups was significant (P < 0.05). Prior to rehabilitation nursing, there was no significant difference in SOMA scores between the two groups (P > 0.05). However, after rehabilitation nursing, both groups exhibited improved SOMA scores, with the observation group scoring higher than the control group. The difference between the two groups was also significant (P < 0.05). In conclusion, compared to routine nursing care, chewing function nursing techniques can alleviate swallowing dysfunction among children with cerebral palsy, enhance their swallowing function, and improve their quality of life. Therefore, this approach is worthy of clinical application and promotion.

Prevention and treatment of microstomia.

The mouth, located in the lower third of the face, is a uniquely visible structure. It serves as a vital organ both aesthetically and functionally, playing a key role in speech, expression, and fundamental oral functions. Consequently, any alterations or defects in its shape, due to various causes, can lead to aesthetic and functional deficiencies. These issues may also result in challenges with social interactions and a decrease in confidence. In cases of microstomia, various surgical approaches are proposed based on the location, extent, shape, and cause of the defect, leading to numerous case reports. Plastic surgeons are proficient in oral reconstruction; however, cases of microstomia are relatively rare, which reduces their familiarity and interest in these cases. Additionally, preferences for oral size and shape vary according to factors such as geographical region and ethnicity, further complicating the functional definition of microstomia. Therefore, both subjective patient and physician judgments play crucial roles in the diagnosis and treatment of microstomia, as these may vary depending on individual and societal aspects. This review aims to classify the various causes and definitions of microstomia, as well as its non-surgical and surgical treatment options, with the goal of the treatment of this condition.

Impact of Denture Use on Oral Health-Related Quality of Life in Yemeni Patients: A Cross-Sectional Analysis.

BACKGROUND We used the 14-item Oral Health Impact Profile-14 (OHIP-14) questionnaire to evaluate the association between sociodemographic variables and oral health-related quality of life in 241 wearers of removable partial or complete dentures attending a single center in Yemen. MATERIAL AND METHODS A total of 241 partial dentures (PD) and complete dentures (CD) wearers were enrolled from the Department of Prosthodontics at the Faculty of Dentistry, Sana'a University, and the University of Science and Technology. Data were collected before the commencement of denture wearing and after 3-6 months of denture use. The questionnaire consisted of sociodemographic information and denture type, and another for the OHIP to assess oral health-related quality of life (OHRQoL), oral health impact profile scale comprises 7 subscales, each evaluating different aspects of oral health and functionality. Descriptive statistics were calculated for participants. Independent t tests were performed to compare different patient groups, focusing on PD and CD wearers. Paired-sample t tests were used to examine changes within patient groups before and after removable denture use. RESULTS Among all participants, 67.6% were male, wearers of CDs were 74.6% male, PDs were 58.3%, and was consistent for CD (71.0%) and PD (72.8%) wearers. The wearing prostheses significantly impacted the OHRQoL of patients using both PDs and CDs (P<0.01). Among CD wearers, 4 of these subscales (3-6) were statistically significant, but the handicaps subscale showed evident reductions in physical pain after treatment among PD wearers. CONCLUSIONS Wearing dentures positively affects the OHRQoL of patients, influencing various aspects of their health, including functional, physical, psychological, and social well-being.

Reliability of mandibular range of motion measurements in healthy children.

Mandibular range of motion (MROM) variables are widely used to evaluate oral function. The aim of this study was to establish the reliability of MROM variables in healthy children. In this cross-sectional study, healthy children were examined 2 weeks apart. The following MROM variables were established: active maximum interincisal opening (AMIO), passive maximum interincisal opening (PMIO), protrusion and left and right laterotrusion. The reliability of the MROM measurements was determined by analysing the intra-class correlation coefficient (ICC), standard error of measurement (SEM), smallest detectable change (SDC) and limits of agreement (LoA). A total of 167 healthy children were examined. The ICC indicated good reliability for AMIO (0.885); excellent reliability for PMIO (0.925); and moderate reliability for protrusion (0.578), laterotrusion left (0.601) and laterotrusion right (0.634). The SDC was 0.9 mm for AMIO, 0.4 mm for PMIO, 2.2 mm for protrusion, 1.6 mm for laterotrusion left and 1.4 mm for laterotrusion right. The LoA was -5.67 to 5.82 for AMIO, -3.90 to 3.57 for PMIO, -3.89 to 3.55 for protrusion, -2.99 to 2.77 for laterotrusion left, and - 2.71 to 2.77 for laterotrusion right. AMIO and PMIO measurements are both highly reliable in healthy children. The low SDC indicate that AMIO and PMIO are promising longitudinal measurements. Protrusion and laterotrusion measurements had moderate reliability. These results support our clinical recommendation to measure AMIO rather than PMIO, as PMIO is more difficult and more time-consuming to perform than AMIO.

Systemic and Oral Characteristics of Convalescent Inpatients Requiring Oral-Health Management by a Dental Specialist during Hospitalization.

Older adults often experience poor oral functions, hindering rehabilitation post-acute disease treatment. However, characteristics of hospitalized patients who would benefit from professional oral-health management (POHM) have not been clarified. Therefore, we aimed to elucidate systemic and oral characteristics of patients requiring POHM during hospitalization in a convalescent hospital. This study included 312 participants admitted to the rehabilitation department of a convalescent hospital for a year. The patients were categorized according to POHM requirements (no-POHM group: 137 patients; POHM group: 175 patients) by discharge. Age, sex, primary disease at admission, Glasgow coma scale (GCS), Functional Independence Measurement (FIM), Mini nutritional assessment-short form (MNA-SF), Functional oral intake scale (FOIS), number of present and functional teeth, Oral Health Assessment Tool (OHAT) scores, and POHM details provided during patient hospitalization were compared. Binomial logistic-regression analysis identified patients requiring POHM as those who had suffered a stroke and had a low number of present teeth, poor overall oral health, low food form, and low motor skills at admission. A high percentage of POHM interventions comprised oral-hygiene care and denture treatment. In summary, patients whose oral health has deteriorated and those experiencing oral-intake difficulties upon admission to a convalescent hospital may require oral-health management.

Interactions between xanthan gum and phenolic acids

The molecular and colloidal-level interactions between two major phenolic acids, gallic and caffeic acid, with a major food polysaccharide, xanthan gum, were studied in binary systems aiming to correlate the stability of the binary systems as a function of pH and xanthan-polyphenol concentrations. Global stability diagrams were built, acting as roadmaps for examining the phase separation regimes followed by the fluorimetry-based thermodynamics of the interactions. The effects of noncovalent interactions on the macroscopic behavior of the binary systems were studied, using shear and extensional rheometry. The collected data for caffeic acid – xanthan gum mixtures showed that the main interactions were pH-independent volume exclusions, while gallic acid interacts with xanthan gum, especially at pH 7 with other mechanisms as well, improving the colloidal dispersion stability. A combination of fluorimetry, extensional rheology and stability measurements highlight the effect of gallic acid-induced aggregation of xanthan gum, both in structuring and de-structuring the binary systems. The above provide a coherent framework of the physicochemical aspect of binary systems, shedding light on the role of xanthan gum in its oral functions, such as in inducing texture, in model complex systems containing phenolic acids.

Nanocatalytic NO gas therapy against orthotopic oral squamous cell carcinoma by single iron atomic nanocatalysts

ABSTRACT Oral squamous cell carcinoma (OSCC) has been being one of the most malignant carcinomas featuring high metastatic and recurrence rates. The current OSCC treatment modalities in clinics severely deteriorate the quality of life of patients due to the impaired oral and maxillofacial functions. In the present work, we have engineered the single-atom Fe nanocatalysts (SAF NCs) with a NO donor (S-nitrosothiol, SNO) via surface modification to achieve synergistic nanocatalytic NO gas therapy against orthotopic OSCC. Upon near-infrared laser irradiation, the photonic hyperthermia could effectively augment the heterogeneous Fenton catalytic activity, meanwhile trigger the thermal decomposition of the engineered NO donor, thus producing toxic hydroxyl radicals (•OH) and antitumor therapeutic NO gas at tumor lesion simultaneously, and consequently inducing the apoptotic cell death of tumors via mitochondrial apoptosis pathway. This therapeutic paradigm presents an effective local OSCC therapeutics in a synergistic manner based on the nanocatalytic NO gas therapy, providing a promising antitumor modality with high biocompatibility.

Associations of sex, age, and number of remaining teeth with performance on oral hypofunction tests.

Oral hypofunction comprises seven aspects of oral condition, including oral hygiene, oral dryness, bite strength, tongue-lip motor function, tongue pressure, masticatory function, and swallowing function. Each of these seven has a single diagnostic criterion; however, the use of a single indicator without consideration of sex, age, or other factors is controversial. The purpose of this study was to evaluate the association between the oral hypofunction test and sex, age, and number of remaining teeth. The study was conducted at 12 facilities by the members of the Japanese Society of Geriatric Dentistry during April to December 2019. The participants comprised 181 healthy older adults aged 65 years and over (56.9% female; age range 65-95 years) who regularly visited these facilities. All tests of oral function and oral status available in Japan were performed on the participants, and the association between these tests and sex, age, and number of remaining teeth was examined. Sex differences were observed in masticatory function, bite force, lip closure force, jaw-opening force, oral diadochokinesis "ka," and tongue coating index (p < .05). In men, age was weakly (r = 0.20-0.40) associated with masticatory function, jaw-opening force, maximum tongue pressure, oral diadochokinesis, and swallowing function. In women, the number of remaining teeth, masticatory function, jaw-opening force, and oral diadochokinesis "ta" and "ka" was also weakly associated with age. Performance on the oral hypofunction test differs by sex, age, and number of remaining teeth. This means that the current single criterion for evaluation requires caution in its interpretation.

In Vitro Assessment of the Fracture Resistance of Different Prosthodontic Materials for Fixed Dental Prostheses.

Fixed dental prostheses (FDPs) are commonly used in prosthodontics to restore missing teeth and improve oral function and esthetics. The selection of prosthodontic materials significantly impacts the fracture resistance of FDPs, thus influencing their clinical success. This study aimed to assess the fracture resistance of different prosthodontic materials commonly used in FDPs through in vitro testing. Thirty standardized FDP specimens were fabricated using three different materials: Monolithic zirconia, heat press lithium disilicate, and metal ceramic. Each group consisted of ten specimens. The specimens were subjected to standardized loading using a universal testing machine until fracture occurred. Fracture resistance values were recorded in Newtons (N) and statistically analyzed using one-way analysis of variance (ANOVA) followed by post-hoc Tukey tests. The mean fracture resistance values for the three materials were as follows: zirconia, 1450 N; lithium disilicate, 1200 N; and metal ceramic, 950 N. Statistical analysis revealed a significant difference among the groups (P < 0.05). Post hoc Tukey tests indicated that zirconia exhibited significantly higher fracture resistance compared to lithium disilicate and metal ceramic (P < 0.05). However, there was no significant difference in fracture resistance between lithium disilicate and metal-ceramic groups (P > 0.05). Within the limitations of this in vitro study, zirconia demonstrated the highest fracture resistance among the tested materials for FDPs, followed by lithium disilicate and metal ceramic. The findings highlight the importance of material selection in achieving optimal clinical outcomes and longevity of fixed dental prostheses.

Association between oral frailty and Prevotella percentage in the oral microbiota of community-dwelling older adults who participated in the CHEER Iwamizawa project, Japan.

Prevotella bacteria are associated with inherent diseases of the oral cavity, such as periodontal disease, and systemic diseases. Oral frailty (OF) has been associated with nursing necessity and death. However, the relationship between OF and oral microbiota has not been fully clarified. This cross-sectional study investigated the association between OF and Prevotella percentage in the oral microbiota of community-dwelling older adults. Oral bacteria species from saliva were identified in 208 community-dwelling older individuals aged ≥60 years in Japan. The proportion of Prevotella in the oral microbiota was classified into three tertile groups, and its relationship with each test item for OF (number of remaining teeth, masticatory performance, oral diadochokinesis, tongue pressure, difficulties eating tough foods, difficulties swallowing tea or soup, number of applicable OF judgement items, and existence of OF) was examined using ordinal logistic regression analysis. The Prevotella proportions were classified into lower, middle and upper groups, comprising 70, 69 and 69 participants, respectively. The three groups showed a significant relationship between the number of remaining teeth (odds ratio [OR]: 0.946, 95% confidence interval [CI]: 0.915-0.977), masticatory performance (OR: 0.897, 95% CI: 0.844-0.953), number of applicable OF judgement items (OR: 1.477, 95% CI: 1.14-1.915), and existence of OF (OR: 4.194, 95% CI: 1.519-11.576). The proportion of Prevotella in oral microbiota was high in individuals with OF. Among the older adults, the type of oral microbiota and systemic diseases may be related to the examination and management of oral function decline.

Temporomandibular Joint Histology

Background: The temporomandibular joint plays a crucial role in daily oral functions like mastication. A comprehensive understanding of the histological components of these joints proves valuable in deciphering their intricate anatomical structures. Purpose of the study: This study aimed to compare the histochemical stains of hematoxylin-eosin and Goldner's trichrome applied to a temporomandibular joint sample using the Wistar Rat as a biomodel. Results: Complete sagittal slices of murine biomodel hemicranium were evaluated and the comprehensive histological technique involved various steps, including perfusion, post-fixation, decalcification, dehydration, clarification, inclusion, cutting, staining, and assembly. The temporomandibular joint specimens were stained using H&amp;E and Goldner's trichrome. The histological description included structures such as the external auditory canal, mandibular fossa and condyle, pterygoid muscles, joint capsule, synovial membrane, articular disc, and articular surface. Special cell types like chondrocytes and synovial cells were also identified. Conclusion: Goldner's trichrome, an underutilized technique, exhibited superior chromatic richness in differentiating the cellular and tissue components of the temporomandibular joint. KEYWORDS: histology, joint capsule, synovial membrane, temporomandibular joint, temporomandibular joint disc, trichrome stain, Wistar rats.

Clinical Performance of Implant-Supported Prostheses in the Rehabilitation of Patients Previously Treated for Medication-Related Osteonecrosis of the Jaws (MRONJ): A Systematic Review.

There is a lack of consensus on managing resultant bone and soft tissue defects or on restoring oral function and aesthetics following medication-related osteonecrosis of the jaws (MRONJ) lesion healing. This clinical challenge presents a dilemma for practitioners. Removable prostheses pose a recurrence risk if poorly fitted and may inadequately restore function or aesthetics in cases of significant bone defect. Dental implant-supported prostheses could enhance function and quality of life, though their risks and indications are not well-defined. This systematic review examines the clinical outcomes and complications associated with implant-supported rehabilitations post-MRONJ surgery. This study was conductedfollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations and it was pre-registered in the Prospective Register of Systematic Reviews (PROSPERO) (CRD42023492539).

High-precision all-in-one dual robotic arm strategy in oral implant surgery

IntroductionDental implantation has emerged as an efficient substitute for missing teeth, which is essential for restoring oral function and aesthetics. Compared to traditional denture repair approaches, dental implants offer better stability and sustainability. The position, angle, and depth of dental implants are crucial factors for their long-term success and necessitate high-precision operation and technical support.MethodWe propose an integrated dual-arm high-precision oral implant surgery navigation positioning system and a corresponding control strategy. Compared with traditional implant robots, the integrated dual-arm design greatly shortens the preparation time before surgery and simplifies the operation process. We propose a novel control flow and module for the proposed structure, including an Occluded Target Tracking Module (OTTM) for occlusion tracking, a Planting Plan Development Module (PPDM) for generating implant plans, and a Path Formulation Module (PFM) for controlling the movement path of the two robot arms.ResultUnder the coordinated control of the aforementioned modules, the robot achieved excellent accuracy in clinical trials. The average angular error and entry point error for five patients who underwent implant surgery using the proposed robot were 2.1° and 0.39 mm, respectively.ConclusionIn essence, our study introduces an integrated dual-arm high-precision navigation system for oral implant surgery, resolving issues like lengthy preoperative preparation and static surgical planning. Clinical results confirm its efficacy, emphasizing its accuracy and precision in guiding oral implant procedures.