No: 1510 Presentation at ESCV 2015: Poster 1 Seroprevalence of IgG antibodies against vaccine-preventable diseases in newcomers to Luxembourg J.M. Hubschen1,∗, E. Charpentier1, P. Weicherding2, C.P. Muller1 1 Department of Immunology, Luxembourg Institute of Health Laboratoire National de Sante, Esch-Sur-Alzette, Luxembourg 2 Direction de la Sante, Division Inspection Sanitaire, Luxembourg City, Luxembourg Background:Although the vaccine coverage of the general population in Luxembourg is above 90%, refugees or asylum seekers may be incompletely vaccinated and susceptible to vaccinepreventable diseases. Especially highly mobile traveller communities played an important role in the spreadof several infectious diseases in recent years. The prevalence of IgG antibodies against vaccinepreventable diseases among newcomers was investigated in order to prevent disease outbreaks in Luxembourg, also in the context of the 2015 WHO measles and rubella elimination goals. Methods:Serumandoral fluidwere collected from406 refugees or asylum seekers between 13 and 70 years from30 different countries, mainly belonging to the Balkans (87%), between May and September 2012. The serum samples were screened for IgG antibodies against the vaccine-preventable diseases measles, rubella, mumps, hepatitis B, tetanus, diphtheria and pertussis. Oral fluid sampleswere screened for antibodies againstmeasles, mumps and rubella virus to investigate whether oral fluid is a suitable alternative and non-invasive specimen for antibody prevalence studies. Results: More than 90% of the study participants had IgG antibodies against rubella,whileonlyabout73%and56%hadantibodies against measles and mumps, respectively. Less than 19% had protective antibodies against hepatitis B virus. Nearly 84% of the study participants had an adequate protection against tetanus, while the diphtheria results showed that for nearly 90% of the newcomers vaccination is recommended. Only about 40% of the study participants had antibodies against pertussis. Some differences according to origin, age and gender of the participants were observed. Based on the total IgG content, all 406 oral fluid samples were considered suitable for measles testing, 397 and 250 were included for rubella and mumps testing, respectively. 93%, 95% and 79% of the test results obtained with the two different specimens were concordant. Conclusion: The majority of the participants needed vaccination against measles/mumps/rubella (58%) and diphtheria/tetanus/pertussis (69%) as they were not protected against at least one of the diseases and against hepatitis B virus (82%). Since a good agreement between serum and oral fluid test results was observed, oral fluid is a suitable alternative and non-invasive specimen for measles and rubella antibody prevalence studies. http://dx.doi.org/10.1016/j.jcv.2015.07.080