Summary. The oral cavity is a complex ecological system in which external factors (biological, individual, social) are closely interconnected with internal factors (tissues of the periodontal complex, dentin metabolites, microbial biofilm, local immune protection, epithelium of the oral cavity) and are in dynamic balance. The aim of the study. To investigate the level and trends of the development of scientific knowledge about oral biofilm and its management, leaving. Materials and methods. 24 еnglish-language and 37 domestic literary sources were processed. Conclusions. A detailed analysis of modern domestic and foreign literature convinces of the need for a thorough study of oral biofilms, as this will illuminate a complete picture of the etiology and pathogenesis of inflammatory diseases of the oral cavity. Having carefully studied biofilms and the mechanisms of their occurrence, we can carry out targeted treatment measures, while destroying the complex links of vital activity and interrelationships of microorganisms.The composition of dental plaque also changes at different anatomical loci in connection with the formed physical and biological properties of each site. A deeper understanding of the significance of dental plaque as a mixed biofilm may have a significant impact on clinical practice. Dental plaque cannot be completely eliminated, but the pathogenic nature of the biofilm can be reduced by reducing the bioburden and maintaining normal microflora with appropriate hygienic methods and oral care products. Key words: dentistry, periodontitis, age, periodontium, microorganisms, biofilm, periodontopathogens
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