Optimal Exposure Research Articles

Ex vivo assessment of sulbactam-durlobactam clearance during continuous renal replacement therapy to guide dosing recommendations.

Sulbactam-durlobactam is approved for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter baumannii-calcoaceticus complex. Patients with serious Acinetobacter infections may require support with continuous renal replacement therapy (CRRT), which presents challenges for optimal dosing of antibiotics. Sulbactam-durlobactam dosing regimens were derived for this population using an ex vivo CRRT model and Monte Carlo simulation (MCS). Transmembrane clearance (CLTM) was determined in hemofiltration (CVVH) and hemodialysis (CVVHD) modes using the Prismaflex M100 and HF1400 hemofilter sets and with effluent rates of 1, 2, and 3 L/h. Pre-filter, post-filter blood, and effluent samples were collected over 60 min to calculate sieving (SC) and saturation (SA) coefficients for CVVH and CVVHD, respectively. An established population pharmacokinetic model was integrated with the CLTM; then, a 1,000 patient MCS was conducted to determine exposures of potential dosing regimens. Adsorption and degradation in the ex vivo CRRT model were negligible. The overall mean ± standard deviation SC/SA was 1.14 ± 0.12 and 0.93 ± 0.08 for sulbactam and durlobactam, respectively. In multivariable regression analyses, effluent rate was the primary driver of CLTM for both drugs. For effluent rates <3 L/h, sulbactam-durlobactam 1 g-1g q8h as 3 h infusion achieved a high probability of pharmacodynamic target attainment while retaining area under the curve exposures consistent with the standard dose in non-CRRT patients. For effluent rates ≥3 to 5 L/h, the optimal regimen was 1 g-1g q6h 3 h infusion. Sulbactam-durlobactam regimens that provide optimum drug exposures for efficacy and safety were identified for CRRT based on the prescribed effluent rate.

Optimum blue light exposure: a means to increase cell-specific productivity in Chinese hamster ovary cells

Research for biopharmaceutical production processes with mammalian cells steadily aims to enhance the cell-specific productivity as a means for optimizing total productivities of bioreactors. Whereas current technologies such as pH, temperature, and osmolality shift require modifications of the cultivation medium, the use of optogenetic switches in recombinant producer cells might be a promising contact-free alternative. However, the proper application of optogenetically engineered cells requires a detailed understanding of basic cellular responses of cells that do not yet contain the optogenetic switches. The knowhow of ideal light exposure to enable the optimum use of related approaches is missing so far. Consequently, the current study set out to find optimum conditions for IgG1 producing Chinese hamster ovary (CHO) cells which were exposed to blue LED light. Growth characteristics, cell-specific productivity using enzyme-linked immunosorbent assay, as well as cell cycle distribution using flow cytometry were analyzed. Whereas too harsh light exposure causes detrimental growth effects that could be compensated with antioxidants, a surprising boost of cell-specific productivity by 57% occurred at optimum high light doses. The increase coincided with an increased number of cells in the G1 phase of the cell cycle after 72 h of illumination. The results present a promising new approach to boost biopharmaceutical productivity of mammalian cells simply by proper light exposure without any further optogenetic engineering.Key points• Blue LED light hinders growth in CHO DP-12 cells• Antioxidants protect to a certain degree from blue light effects• Illumination with blue LED light raises cell-specific productivity

Shaping future preschool teachers in Ethiopia: A qualitative evaluation of pedagogical competence development mechanisms

Preschool teacher training programs in Ethiopia are designed to enhance the teaching skills of future teachers. Grounded in this context, this study aimed at evaluating how a pre-service teacher education program develops these essential pedagogical competences through coursework and hands-on training. Using phenomenological design, the research focuses on preschool teacher candidates, instructors, department heads, and education officials from six selected teacher education colleges across Ethiopia, involving a total of 18 participants chosen for convenience. To gather qualitative data, the study employed semi-structured interviews and direct observations of lesson facilitation. The findings indicate a strong and effective preschool teacher education program that develops the pedagogical competencies of preschool teachers. However, it was highlighted that there are significant challenges such as limited practical exposure, resource constraints, and language barriers. Key findings emphasize the need for improved support mechanisms, highlighting the importance of practical training components in the improved curriculum, optimum practical exposures, enriching extracurricular activities, rigorous assessment methods, and the provision of constructive feedback.

Mechanism of Improving Etching Selectivity for E-Beam Resist AR-N 7520 in the Formation of Photonic Silicon Structures

The selectivity of the reactive ion etching of silicon using a negative electron resist AR-N 7520 mask was investigated. The selectivity dependencies on the fraction of SF6 in the feeding gas and bias voltage were obtained. To understand the kinetics of passivation film formation and etching, the type and concentration of neutral particles were evaluated and identified using plasma optical emission spectroscopy. Electron temperature and electron density were measured by the Langmuir probe method to interpret the optical emission spectroscopy data. A high etching selectivity of 8.0 ± 1.8 was obtained for the etching process. The optimum electron beam exposure dose for defining the mask was 8200 pC/m at 30 keV.

Optimisation of nitrogen plasma exposure time for surface modification of cotton fibre

Surface modification via plasma treatment is useful in improving textile-based wound dressing functionality. This study was conducted to optimise the nitrogen plasma exposure time and its effect on the cotton surface (CS) properties at a constant nitrogen flow rate of 20 sccm for 5 to 30 min. The optimisation was done by analysing the alteration in morphology, functional group composition, crystallinity phase, electrokinetic potential, and colour of CS as subjected to nitrogen plasma. CS experienced an etching effect due to the presence of microcracks on its surface, with its electrokinetic potential becoming less negative, ranging from -5.51 to –8.05 mV. Then, the nitrogen functional group was detected on CS ranging from 2.9% to 4.5%, with its whiteness index reduced to 8.67% compared to the pristine cotton. As a result, 20 min was selected as the optimum exposure time for surface treatment. An exposure time of 30 min showed an early sign of degradation, which reduced its crystallinity index by 11.1%. Apparently, the CS is activated as exposed to the nitrogen plasma and experiences slight changes in its molecular structure without affecting its bulk properties.

Evaluating the Potential of Green Light Exposure on Nociception-A Mini Review.

The capacity of animals to react to unpleasant stimuli that might endanger their integrity is known as nociception. Pharmacological treatments do not show satisfactory results in response to nociception. In the recent era, light therapy emerged as a potential non-pharmacological approach for treating various diseases, including seasonal affective disorders, migraine, pain, and others. Evaluating the potential of green light exposure on nociception involves studying its effects on different types of pain and pain-related conditions and determining the optimal exposure methods. This review provides the beneficial effects of green light on the reduction in the frequency of pain. The green light exposure on nociception changes the activity of pain-related genes and proteins in cells. This review could provide insights into the underlying mechanisms by which green light modulates pain. Overall, evaluating the potential of green light exposure on nociception requires a multidisciplinary approach and should consider the safety, efficacy, optimal dose, and duration of green light exposure and the type of pain. However, few studies have been reported so far; therefore, light therapy for treating migraines require more studies on animal models to provide precise results of light effects on nociception.

Dynamic Monitoring and Analysis of Dual-Axis movement of SPV Power Plant Parameters under various Atmospheric Conditions

This research paper presents comprehensive insight into the testing of a 1 KW sun tracking photovoltaic (PV) performance. The study uses a state-of-the-art real-time string monitoring system to allow this analysis while covering an extensive variety of atmospheric conditions. The design of the 1 KW solar tracker system incorporates a tracking sensor circuit, motor driver circuit, string monitoring system, and solar tracker control circuit. Solar tracking systems boost energy generation by adjusting the angle of PV panels to optimum sunlight exposure. The effectiveness of such devices can, however, be severely impacted by atmospheric changes. In a photovoltaic (PV) facility, we have successfully developed and placed into use a real-time system for monitoring certain strings. The system collected data on key parameters such as current, voltage, and temperature, providing insights into the health and efficiency of each string. Our study encompassed various atmospheric conditions, including clear skies, cloudy days, and fluctuating solar radiation. A DAQ system developed communicate with observations such as the voltage and current of photovoltaic arrays and the voltage and current of DC motors. When comparing the dual-axis tracking system to the static PV system, a maximum of 48% more electricity can be extracted. Both days with clear skies and days with clouds provide satisfactory results. The supply for the tracker control circuit comes from PV cells. Therefore, there is no need for any auxiliary supply, such as a battery.

Customized ventral bony and dural opening in the transplanum/transtuberculum and transclival variants of extended endoscopic endonasal approach to suprasellar craniopharyngiomas: an approach-based stepwise cadaveric dissection and clinical applicability.

Optimal initial exposure through an extended endoscopic endonasal approach (EEA) for suprasellar craniopharyngiomas ensures safe and unrestricted surgical access while avoiding overexposure, which may prolong the procedure and increase neurovascular adverse events. Here, the authors outline the surgical nuances of a customized bony and dural opening through the transplanum/transtuberculum and transclival variants of the extended EEA to suprasellar craniopharyngiomas based on the tumor-pituitary stalk relationship. A stepwise cadaveric dissection and intraoperative photographs relevant to the approaches are also provided. Safe maximal resection of suprasellar craniopharyngiomas through extended EEAs can be feasibly and safely achieved by implementing of tailored ventral exposure.

Alexis retractor efficacy in transthoracic thoracoscopically assisted discectomy for thoracic disc herniations.

A transthoracic anterior or lateral approach for giant thoracic disc herniations is a complex operation which requires optimal exposure and maximal visualisation. Traditional metal rigid retractors may inflict significant skin trauma especially with prolonged operative use and limit the working angles of endoscopic instrumentation at depth. We pioneer the use of the Alexis retractor in transthoracic thoracoscopically assisted discectomy for the first time. The authors describe and demonstrate the technical use of the Alexis retractor during operative cases. Patient positioning, clinical rationale and operative nuances are elucidated for readers to gain an appreciation of the transthoracic approach to thoracic disc herniations. The advantages of the Alexis retractor include minimally invasive circumferential flexible retraction, facilitation of bimanual instrument use, diminished risk of surgical site infections and reduced rib retraction leading to less postoperative pain. Use of the flexible and intuitive Alexis retractor maximises operative exposure and is an effective adjunct when performing complex transthoracic approaches for thoracic disc herniations.

Laser Powder Bed Fusion of Hard‐Phase Containing Co‐Base Alloy

This work considers the processing of the hard‐phase containing CoCrW‐alloy Celsit F using powder bed fusion‐laser beam/metal (PBF‐LB/M), whereby a suitable process window for producing dense parts having a low‐defect density is determined. Several cuboid specimens are manufactured by varying the exposure parameters (laser power, hatch distance, scanning speed). With the help of quantitative image analysis, the samples are evaluated regarding crack density and porosity, and optimal exposure parameters are derived. Dense samples with a low defect density can be produced if the energy density is 60–70 J mm−3 and the base‐plate is preheated to 800 °C. Choosing lower energy densities leads to increased pore formation, whereas higher energy densities result in increased ablation and cracking. With a view to a later application in which additively manufactured hot work tools are made of Celsit F, the possibility of introducing internal cavities as potential cooling channels is considered. It can be shown that the hardness sideways is lower than above and below the cavity due to a changed microstructure and locally different heat dissipation. The results of this work give a first guideline for the PBF‐LB/M‐processing of wear‐resistant CoCrW alloys with a high hard phase volume content to tools for hot working.

Prediction of poor exposure in endoscopic mitral valve surgery using computed tomography.

In endoscopic mitral valve surgery, optimal exposure is crucial. This study aims to develop a predictive model for poor mitral valve exposure in endoscopic surgery, utilizing preoperative body profiles and computed tomography images. We enrolled patients undergoing endoscopic mitral valve surgery with available operative video and preoperative computed tomography. The degree of valve exposure was graded into 0 (excellent), 1 (fair), 2 (poor) and 3 (very poor). Intrathoracic dimensions-anteroposterior width (chest anteroposterior) and left-to-right width (chest width) of the thorax, height of right hemi-thorax (chest height), angle between the left ventricular axis and the horizontal plane (left ventricle apex angle), heart width, level of diaphragm in midline, and vertical distance between the midline diaphragm level and the highest top of the right diaphragm (Δdiaphragm) were measured. Among 263 patients, mitral valve exposure was graded as 0 in 131 (49.8%), 1 in 72 (27.4%), 2 in 46 (17.5%) and 3 in 14 (5.3%). Body mass index, chest width, left ventricle apex angle, heart width and Δdiaphragm were identified as independent predictors of grades 2 and 3 exposure by stepwise logistic regression analysis, with an area under the receiver operating characteristic curve of 0.822 (P < 0.001). Univariate logistic regression for grade 3 exposure prediction revealed that Δdiaphragm had the largest area under the curve (0.826, P < 0.001). Poor mitral valve exposure occurred in approximately one-fourth of the endoscopic surgery series and might be predicted preoperatively using body mass index and computed tomography measurements to help determine the surgical approach.

Dosing and Exposure of Vancomycin With Continuous Infusion: A Retrospective Study.

Vancomycin continuous infusion (CI) has suggested benefits over intermittent infusion: reduced nephrotoxicity, higher target attainment, and simpler therapeutic drug monitoring (TDM). Empiric dosing regimens range from 30-60 mg/kg/day and it is unclear which regimen results in optimal exposure. This study evaluates whether a dosing regimen of 45 mg/kg/day after a 20 mg/kg loading dose for patients with estimated glomerular filtration rate (eGFR) ≥ 50 mL/min results in adequate exposure. We retrospectively analyzed plasma concentrations from patients treated with vancomycin CI as routine clinical care between February and October 2021. Patients under 18 years old, with renal replacement therapy, reduced creatinine clearance (Chronic Kidney Disease Epidemiology Collaboration < 50 mL min/1.73 m2) or outpatient antibiotic therapy were excluded. Dose, renal function, and blood draw procedures were assessed for each measured vancomycin sample. Initially, 121 samples were included. Subsequently, 7 samples, 6 of which with concentrations ≥ 40 mg/L, were verified to be incorrectly drawn and excluded. With doses of 40-50 mg/kg/day concentrations ranged from 18.4-61.0 mg/L. Only 25% were within the target window of 17-25 mg/L and 15% were ≥ 40 mg/L. Supratherapeutic concentrations were observed in 89% of samples from patients dosed 40-60 mg/kg/day with eGFR 50-80 mL/min. Concluding, an empiric dosing regimen of 45 mg/kg results in too high vancomycin exposure and thus we recommend lower doses and differentiation according to renal function. Additionally, when measuring concentrations over 40 mg/L incorrect sampling must be excluded before dose adjustment and the large variability in exposure between patients, warrants the need for swift TDM.

Frenotomy Provides Improved Direct Laryngoscopy Exposure in Select Adult Patients With Ankyloglossia.

Objective: To analyze the effects of lingual frenotomy on adults with restrictive ankyloglossia and difficult direct laryngoscopy exposure. Methods: A case series study was conducted. Restriction of tongue protrusion due to ankyloglossia was identified in 2 patients who had a history of suboptimal true vocal fold (TVF) exposure on direct laryngoscopy for phonomicrosurgery. Inadequate exposure of the vocal folds was achieved on direct laryngoscopy attempts with manual tongue protrusion. Mandibular tori were not present in these patients. An intraoperative lingual frenotomy was performed in both patients. Results: After frenotomy and with manual tongue protrusion, direct laryngoscopy exposure was substantially improved allowing for considerably more visualization of the anterior TVFs. Conclusion: Lingual frenulum procedures with manual tongue protrusion should be considered in select adult patients with restrictive ankyloglossia affecting optimal direct laryngoscopy exposure.

Microfluidics-derived hierarchical microparticles for the delivery of dienogest for localized endometriosis therapy

Drug therapy is one of the most important strategies for treating gynecological diseases. Local drug delivery is promising for achieving optimal regional drug exposure, considering the complex anatomy and dynamic environment of the upper genital tract. Here, we present microparticle-based microcarriers with a hierarchical structure for localized dienogest (DNG) delivery and endometriosis treatment. The microparticles were fabricated by microfluidics and consisted of photo-crosslinked bovine serum albumin hydrogel particles (D@P-B MPs) encapsulating DNG-loaded PLGA (poly lactic-co-glycolic acid) microspheres. Such design enables the microparticles to have sustained release capacity and cell adhesion ability. Based on this, the microparticles were applied for the treatment of peritoneal endometriosis through intraperitoneal injection. The performance of the microparticles in inhibiting the growth of ectopic lesions as well as their anti-inflammatory, anti-angiogenesis, and pelvic pain-relieving effects are well demonstrated in vivo. These findings indicate that the present hierarchical microparticles are good candidates for localized treatment of endometriosis and are promising for the management of gynecological diseases. STATEMENT OF SIGNIFICANCE: We prepared photo-crosslinked bovine serum albumin hydrogel particles (D@P-B MPs) encapsulating DNG-loaded PLGA microspheres using microfluidic electrospray. Such hierarchical structure provided multiple functions of the particles as drug carriers. The hierarchical microparticles not only supported the sustained release of drugs but also provided adhesion to human ectopic endometrial stromal cells. The hierarchical microparticles represented a localized treatment method for endometriosis and is promising for the management of gynecological diseases.

Photoelectricity Theory-Based Concrete Crack Image Segmentation and Optimal Exposure Interval Research

To solve the problem of low accuracy in automatic concrete crack image segmentation and the non-standardization of concrete crack image datasets, an exposure-based concrete crack image capture scene characterization method was proposed, and the optimal exposure interval for crack segmentation was presented by multiple scene image capture experiments. First, current public crack datasets were collected and analyzed, and it was shown that improper spatial resolution, mislabeling, overexposure, and defocus are frequent non-standardization problems in crack dataset production. Through the analysis of the photoelectric principle in concrete crack imaging, an equivalent exposure was set as a core indicator for scene characterization. Twenty-one indoor scenes were designed by varying the illumination intensity and exposure time, and the experimental results showed that an equivalent exposure can be a core control index for scene characterization. The grayscale distribution law of concrete crack images was analyzed with four specimens’ images captured indoors in 50 exposure scenes, and the segmentation accuracy of an image from each scene was calculated through comparison with corresponding manually labeled binary files. The experiment’s results revealed that 5~50 lx·s was the optimal equivalent exposure interval for concrete crack image segmentation, in which better segmentation accuracy was achieved with an F1 score of up to 96.3%.

Comparative assessment of direct and indirect cold atmospheric plasma effects, based on helium and argon, on human glioblastoma: an in vitro and in vivo study

Recent research has highlighted the promising potential of cold atmospheric plasma (CAP) in cancer therapy. However, variations in study outcomes are attributed to differences in CAP devices and plasma parameters, which lead to diverse compositions of plasma products, including electrons, charged particles, reactive species, UV light, and heat. This study aimed to evaluate and compare the optimal exposure time, duration, and direction-dependent cellular effects of two CAPs, based on argon and helium gases, on glioblastoma U-87 MG cancer cells and an animal model of GBM. Two plasma jets were used as low-temperature plasma sources in which helium or argon gas was ionized by high voltage (4.5 kV) and frequency (20 kHz). In vitro assessments on human GBM and normal astrocyte cell lines, using MTT assays, flow cytometry analysis, wound healing assays, and immunocytochemistry for Caspase3 and P53 proteins, demonstrated that all studied plasma jets, especially indirect argon CAP, selectively induced apoptosis, hindered tumor cell growth, and inhibited migration. These effects occurred concurrently with increased intracellular levels of reactive oxygen species and decreased total antioxidant capacity in the cells. In vivo results further supported these findings, indicating that single indirect argon and direct helium CAP therapy, equal to high dose Temozolomide treatment, induced tumor cell death in a rat model of GBM. This was concurrent with a reduction in tumor size observed through PET-CT scan imaging and a significant increase in the survival rate. Additionally, there was a decrease in GFAP protein levels, a significant GBM tumor marker, and an increase in P53 protein expression based on immunohistochemical analyses. Furthermore, Ledge beam test analysis revealed general motor function improvement after indirect argon CAP therapy, similar to Temozolomide treatment. Taken together, these results suggest that CAP therapy, using indirect argon and direct helium jets, holds great promise for clinical applications in GBM treatment.

Influence of exposure protocol, voxel size, and artifact removal algorithm on the trueness of segmentation utilizing an artificial-intelligence-based system.

To evaluate the effects of exposure protocol, voxel sizes, and artifact removal algorithms on the trueness of segmentation in various mandible regions using an artificial intelligence (AI)-based system. Eleven dry human mandibles were scanned using a cone beam computed tomography (CBCT) scanner under differing exposure protocols (standard and ultra-low), voxel sizes (0.15mm, 0.3mm, and 0.45mm), and with or without artifact removal algorithm. The resulting datasets were segmented using an AI-based system, exported as 3D models, and compared to reference files derived from a white-light laboratory scanner. Deviation measurement was performed using a computer-aided design (CAD) program and recorded as root mean square (RMS). The RMS values were used as a representation of the trueness of the AI-segmented 3D models. A 4-way ANOVA was used to assess the impact of voxel size, exposure protocol, artifact removal algorithm, and location on RMS values (α = 0.05). Significant effects were found with voxel size (p < 0.001) and location (p < 0.001), but not with exposure protocol (p = 0.259) or artifact removal algorithm (p = 0.752). Standard exposure groups had significantly lower RMS values than the ultra-low exposure groups in the mandible body with 0.3mm (p = 0.014) or 0.45mm (p < 0.001) voxel sizes, the symphysis with a 0.45mm voxel size (p = 0.011), and the whole mandible with a 0.45mm voxel size (p = 0.001). Exposure protocol did not affect RMS values at teeth and alveolar bone (p = 0.544), mandible angles (p = 0.380), condyles (p = 0.114), and coronoids (p = 0.806) locations. This study informs optimal exposure protocol and voxel size choices in CBCT imaging for true AI-based automatic segmentation with minimal radiation. The artifact removal algorithm did not influence the trueness of AI segmentation. When using an ultra-low exposure protocol to minimize patient radiation exposure in AI segmentations, a voxel size of 0.15mm is recommended, while a voxel size of 0.45mm should be avoided.

Efficient automated high dynamic range 3D measurement via deep reinforcement learning.

High dynamic range 3D measurement technology, utilizing multiple exposures, is pivotal in industrial metrology. However, selecting the optimal exposure sequence to balance measurement efficiency and quality remains challenging. This study reinterprets this challenge as a Markov decision problem and presents an innovative exposure selection method rooted in deep reinforcement learning. Our approach's foundation is the exposure image prediction network (EIPN), designed to predict images under specific exposures, thereby simulating a virtual environment. Concurrently, we establish a reward function that amalgamates considerations of exposure number, exposure time, coverage, and accuracy, providing a comprehensive task definition and precise feedback. Building upon these foundational elements, the exposure selection network (ESN) emerges as the centerpiece of our strategy, acting decisively as an agent to derive the optimal exposure sequence selection. Experiments prove that the proposed method can obtain similar coverage (0.997 vs. 1) and precision (0.0263 mm vs. 0.0230 mm) with fewer exposures (generally 4) compared to the results of 20 exposures.

Advanced Body Measurement Techniques Can Complement Current Methods of Cytotoxic Chemotherapy Dose Prescription

Within chemotherapy, estimates of a patient’s body surface area (BSA) are used to calculate drug dosages. However, the use of BSA for calculating chemotherapy dosage has been heavily criticised in previous literature, with potentially significant implications for the effectiveness and toxicity of treatment. BSA has been found to be a poor indicator of optimal drug exposure that does not account for the complex processes of cytotoxic drug distribution and elimination. In addition, differences in BSA estimates between existing formulae have been shown to be so large that they can affect patients’ mortality, particularly in patients with atypical body types. This uncertainty associated with BSA prediction may decrease the confidence of practitioners when determining chemotherapy dosages, particularly with regards to the risk of excess toxicity from over-dosing, or a reduced anti-cancer effect due to under-dosing. The use of national dose-banding in the UK may in some cases account for possible inaccuracies, but the threshold of variance in this case is small (+/−6%). Advanced body measurement techniques, utilising digital tools such as three-dimensional (3D) surface imaging, capture accurate external dimensions and detailed shape characteristics of the human body. Measures of body shape describe morphological variations that cannot be identified by traditional anthropometric techniques and improve the prediction of total body fat and distribution. It is our view that the use of advanced body measurement techniques can provide practitioners with tools for prescribing chemotherapy dosages that are valid for individuals, regardless of their body type.

An innovative diatomite-polypyrrole composite for highly efficient Cr (VI) removal through optimized adsorption via surface response methodology

The release of liquid effluents containing heavy metals, notably Cr (VI), into the environment is a significant contributor to water pollution. Consequently, there is a growing concern about treating these effluents before their discharge. In this context, our study introduces an innovative approach to produce a novel chloride-doped polypyrrole/Diatomite (Cl-PPy/DT) nanocomposite through in situ polymerization. We examined the physicochemical properties of Cl-PPy/DT using various analytical techniques, including structural, textural, morphological, and thermal analyses, confirming the successful formation of the composite. For Cr (VI) removal via batch adsorption, the efficiency of Cl-PPy/DT surpassed that of Cl-PPy and diatomite by 2.21 and 3.75 times, respectively, at a Cr(VI) concentration of 25 ppm. This suggests a robust synergistic effect between diatomite and Cl-PPy, where both components resist aggregation, resulting in a loose structure and optimal exposure of active sites. Using response surface methodology, we refined adsorption parameters such as contact time, initial metal concentration, and adsorbent quantity. Results indicated that adsorption followed a quadratic polynomial model with high regression parameters (R2 value = 99.6%). Kinetic findings demonstrated that Cr(VI) adsorption on Cl-PPy/DT aligned with the pseudo-second-order model. Moreover, at 25 °C, the Langmuir model effectively correlated with equilibrium data, revealing a maximum adsorption capacity (qmax) of 89.97 mg/g for the Cl-PPy/DT adsorbent. Notably, the adsorbent exhibited renewability and reusability for up to four cycles, indicating its potential for large-scale use as a competitive adsorbent.