Orodispersible films (ODFs) are promising dosage forms for special patient populations like paediatrics or elderly persons. By printing active pharmaceutical ingredients (APIs) onto orodispersible films, the flexibility of drug dosing is increased and therefore provides potential for personalized medicines. Until now, only small-scale experiments have been conducted, where continuous jetting was performed,but no continuous ODF production was realized. This study deals with the technology transfer from a small-scale inkjet printing system to a pilotscale process by incorporating the same print head assembly into a continuous ODF production process. ODFs made from hydroxypropylcellulose were non-continuously printed multiple times with test ink containing a blue colorant as model drug and were compared to continuously printed ODFs. To identify optimal manufacturing conditions, parameter settings like firing frequencies, resolution, voltage, etc. were varied and these effects were analysed by UV–Vis spectroscopy, image analysis and light microscopy. During continuous production, a linear correlation between firing frequency (100 to 600 Hz) and deposited colourant content could be observed (R = 0.999) as well as for the applied voltage (90–110 V) and the ink content (R = 0.998). A minor impact of the distance between the print head and the substrate was observed. By increasing the natural resolution (50 dpi) of the print head, the deposited ink amount could be doubled. A transfer from the non-continuous production (1 layer of 1 cm × 2 cm with a resolution of 750 dpi × 750 dpi) to the continuous production (corresponding to 380 Hz firing frequency on 6 cm2 ODF) was successfully performed. Furthermore, image analysis was proven as useful tool for process analytical technology (PAT) of the continuously printed ODFs. The continuous ODF production with direct printing enabled various printing concepts, which may serve for individualized dosing in personalized medicine treatment in the near future.