Nanoporous Pt–Co alloys show promising application in chemical catalysis because of low Pt loading, enhanced stability, and high catalytic activity. In this paper, we investigate the tensile mechanical properties of structurally disordered nanoporous Pt–Co alloys via molecular dynamics simulations, emphasizing on the influence of Co atomic concentration. The results demonstrate that alloying could significantly improve the mechanical properties of nanoporous metals (NPMs) and the enhancement of disordered structures is slightly attenuated compared to ordered structures. Similar to conventional NPMs, the dominated plastic deformation of nanoporous Pt–Co alloys is the axial yielding of ligaments. It is found that the Young's modulus and strength of structurally disordered nanoporous Pt–Co alloys are the strongest when the Co atomic concentration is about 24% (at%), indicating an optimum atomic concentration to produce the strongest mechanical properties. The critical value is fairly approximate to the Co concentration in the structurally ordered NP-Pt 3 Co. In addition to further understanding the mechanical behavior of nanoporous alloys, the study provides a promising strategy for structural design and performance optimization in the application of industrial fields. • Structurally disordered nanoporous alloys with stochastic bicontinuous structure are further designed and investigated. • The mechanical dependence of nanoporous Pt–Co alloys on Co concentration are explored via MD simulations. • Alloying could significantly enhance the mechanical properties of nanoporous metals. • With the Co concentration of ∼24% (at%), the mechanical properties of structurally disordered alloys are the strongest. • The phenomenon might be attributed to the regular stoichiometric ratio of Pt 3 Co.