Lighting control systems are essential in modern building automation and smart homes, efficiently managing illumination to enhance energy conservation and user comfort. This project tackles energy consumption challenges in hospital buildings by introducing Intelligent Lighting Control Systems (ILCS) that take natural light and occupancy into account, driven by Artificial Neural Networks (ANN) and diverse machine learning algorithms. In our study, we collected sensor data, processed it, and designed a lighting control system employing a feedforward neural network and various machine learning algorithms. Surprisingly, our research found that a linear regression algorithm surpassed the ANN-based system in this context. We implemented a prototype, tested it on hardware, and obtained the expected results. This research marks progress towards optimizing energy use in hospital buildings and contributing to sustainability endeavors. By combining ILCS and machine learning, it offers a promising approach for more efficient and eco-friendly lighting systems