Optimization of delivery routes is one form of increasing business productivity to achieve the company's main goal of distributing each product to customers. The Traveling Salesman Problem (TSP) is a combinatorial optimization problem where a salesman goes on a distribution journey that starts from the depot, then visits all customers exactly once, and ends with returning to the depot. This study aims to optimize the distribution route of carton products for packaging companies using the TSP model. The research methodology includes observation, interviews, and document studies to understand the distribution process of carton products at packaging companies. To complete the TSP model, Branch and Bound (BB) and Nearest Neighbor (NN) methods are applied to find the best solution for determining the distribution route of carton products. The way the BB method works is by utilizing branch cuts and boundaries to reduce search space and speed up the resolution process. In the NN method, the nearest point is chosen to get the shortest route distance. Research findings show that the use of the BB method results in a mileage difference from the initial route of 125 km (53% more efficient) and a fuel cost difference of 121,231 IDR (45% cheaper). Meanwhile, the NN method results in a mileage difference from the initial route of 115 km (48.94%) and a fuel cost difference of 109,901 IDR (41.27%). So, the method that produces the best solution is the BB method. The limitations of this study lie in the scale of the model used and the assumptions underlying the analysis. Future research can broaden the scope of the model and consider other factors that may affect the distribution of carton products. The results of this study contribute to improving the efficiency of carton product distribution.