In this investigation, Taguchi's grey relational analysis (GRA) is utilized to optimize parameters in an orthotropic steel deck section subjected to thermo‐mechanical tensioning. In this study, it is aimed to determine optimal values for deck thickness, welding sequence, and welding speed, which are evaluated through finite‐element analysis based on outputs such as longitudinal stress, transverse stress, and deflection. In this study, a previously validated numerical simulation model is extended by conducting a parametric analysis to investigate the influence of varying parameters on the model's behavior. An analysis of variance is conducted to identify the most significant variable affecting the input parameters. Additionally, a confirmatory test is also performed to validate the characteristics of the Grey Relational Grade. In the results, it is indicated that faster welding speeds result in increased deflection of the deck plate. Furthermore, the transition from compressive to tensile longitudinal stress is more abrupt in thinner decks (9–10 mm) compared to thicker decks (11–12 mm). This redistribution of residual stresses is attributed to the increasing thickness of the deck plate. Optimal input levels (A2–B1–C1: 10 mm deck thickness, welding sequence case 1, and 0.005 m s−1 welding speed) are determined using GRA. Welding speed contributes the maximum to the optimization results among the evaluated variables.