A vital component that is frequently employed in the industrial powder conveying sector is the fluidized bed. In the light of powder unloading with a fluidized bed as the research object, an orthogonal experiment with two factors and four levels was established for the structural parameters of the fluidized bed. In the case of different noise factors, 16 schemes are designed and all schemes via computational fluid dynamics numerical simulation. The Taguchi method and regression analysis are used to analyze the response. Finally, the accuracy of the optimization results is tested. The results show that gas velocity decreases sharply at the airway’s entrance and, then, gas flows to the second half of the airway and velocity decreases steadily and uniformly. Airway arc length L exerts a greater effect on the signal-to-noise ratio (SNR) than airway height H. The parameter combination of 180 mm L and 17 mm H for obtaining the optimal velocity distribution uniformity is determined. The test results indicate that the overall fluidization effect of the fluidized bed with the optimal parameters is better. The linked research findings can be used as a guide when designing a fluidized bed system for transporting comparable powder.