Optimal Stiffness Research Articles

Seismic performance of group pile foundation with ground improvement during liquefaction

A pile foundation with ground improvement under the footing is a composite foundation with the objectives of enhancing the seismic performance and rationalizing the substructure by combining the pile foundation with ground improvement. Although the effectiveness of this method has been confirmed in previous studies for application to soft grounds, the applicability of this method to liquefiable grounds has yet to be fully investigated. In this study, therefore, centrifuge model tests and finite element analyses were conducted to clarify the effectiveness of this method and to ascertain the improvement in strength (stiffness) when the method is applied to a liquefiable ground. Firstly, in order to investigate the effect of an improved ground on the behavior of the pile foundation during liquefaction, dynamic centrifuge model tests were conducted for three cases with different strengths of the improved ground. Then, three-dimensional soil–water coupled finite element analyses of the centrifuge model experiments were performed to validate the applicability of the analytical method. After that, parametric studies, in which the strength of the improved ground and the input ground motion were changed, were conducted using the same analytical model. The results confirmed that the horizontal displacement of the pile heads was reduced by the improved ground even in the liquefiable ground, and that the effect of this reduction was more remarkable in cases of high stiffness of the improved ground. Furthermore, it was possible to reduce the bending moments at the pile heads by applying the ground improvement. However, since the bending moment at the boundary between the improved ground and the natural ground became the local maximum, there was an optimum stiffness of the ground improvement at which the maximum bending moment of the piles was reduced. This is because improving the ground around the pile heads has the same effect as extending the footing. It was thus concluded that the behavior of the pile foundation is similar to that of a composite foundation comprised of a caisson and group piles.

The effects of footplate stiffness on push-off power when walking with posterior leaf spring ankle-foot orthoses

BackgroundMany studies on ankle-foot orthoses investigated the optimal stiffness around the ankle, while the effect of footplate stiffness has been largely ignored. This study investigated the effects of ankle-foot orthosis footplate stiffness on ankle-foot push-off power during walking in able-bodied persons. MethodsTwelve healthy participants walked at a fixed speed (1.25 m·s−1) on an instrumented treadmill in four conditions: shod and with a posterior leaf-spring orthosis with a flexible, stiff or rigid footplate. For each trial, ankle kinematics and kinetics were averaged over one-minute walking. Separate contributions of the ankle joint complex and distal hindfoot to total ankle-foot power and work were calculated using a deformable foot model. FindingsPeak ankle joint power was significantly higher with the rigid footplate compared to the flexible and stiff footplate and not different from shod walking. The stiff footplate increased peak hindfoot power compared to the flexible and rigid footplate and shod walking. Total ankle-foot power showed a significant increase with increasing footplate stiffness, where walking with the rigid footplate was comparable to shod walking. Similar effects were found for positive mechanical work. InterpretationA rigid footplate increases the lever of the foot, resulting in an increased ankle moment and energy storage and release of the orthosis' posterior leaf-spring as reflected in higher ankle joint power. This effect dominates the power generation of the foot, which was highest with the intermediate footplate stiffness. Future studies should focus on how tuning footplate stiffness could contribute to optimizing ankle-foot orthosis efficacy in clinical populations.

Analytical study of stiffened multibay planar coupled shear walls

Placing stiffening coupling beams at some levels of a coupled shear wall (CSW) structure is a proper way to enhance the coupling effects and reduce the interstory drifts of the structure. The resulting structural systems are called stiffened CSWs. To date, rigorous closed-form solutions for stiffened multibay planar CSWs subjected to lateral loading have not yet been derived. To solve this problem, a new approach based on the displacement method was proposed to establish the governing equations and boundary conditions, in which the rotation of the cross sections of walls was decomposed into two components: one associated with the axial deformations of wall piers and the other associated with the flexural and shear deformations of coupling beams. The closed-form solutions for the lateral displacement and rotation components were derived for standard load cases, which were verified to have high accuracy. The analytical solutions indicate that the distributions of the lateral displacements and rotation components along the structural height only depend on four dimensionless parameters, which are related to the composition ratio of the moment of inertia of the wall piers about their common centroid, the ratios of the span stiffness of the ordinary coupling beams to that of the wall piers and that of the stiffening beams, and the relative stiffness level, respectively. Parametric studies were further conducted to investigate the influence of these governing parameters on the degree of coupling, interstory drift ratios, and rotation components. It was found that the optimal stiffening levels for achieving the maximum degree of coupling commonly range from 0.06 to 0.50, and those for achieving the minimum of the maximum interstory drift ratio commonly range from 0.59 to 0.80. These findings provide useful implications for the optimization design of stiffened multibay CSWs.

Optimization of a type of elastic metamaterial for broadband wave suppression

The optimal design is studied for a type of one-dimensional dissipative metamaterial to achieve broadband wave attenuation at low-frequency ranges. The complex dispersion analysis is made on a super-cell consisting of multiple mass-in-mass unit cells. An optimization algorithm based on the sequential quadratic programming method is used to design the wave suppression of target frequencies by coupling multiple separate narrow bandgaps into a broad bandgap. A new objective function is proposed in the optimization process for a continuous bandgap. Then, the continuous frequency range with low-wave transmissibility is optimized to achieve the maximal width of bandgap. The stiffness optimization of super-cell gives the broad bandgap from 10 Hz to 22.9 Hz at low-frequency ranges. In addition, numerical simulations are conducted for a type of dissipative metamaterial composed of a finite number of periodicities. The level of vibration isolation can be tuned by adjusting a critical value in the optimization scheme. The wave suppression in the numerical simulation well coincides with the obtained bandgaps and verifies the optimization results.

Numerical Automated Stiffness Optimization of a Thin Television Back-Cover Module: Research on the Industrial Problem

Numerical Automated Stiffness Optimization of a Thin Television Back-Cover Module: Research on the Industrial Problem

Elasticity of the Achilles Tendon in Individuals With and Without Plantar Fasciitis: A Shear Wave Elastography Study.

The elastic properties of the Achilles tendon (AT) are altered in local injury or other diseases and in response to changes in mechanical load. Recently, elastography has been used to evaluate variations in tendon elastic properties, mainly among healthy individuals or athletes. Therefore, this study evaluated the biomechanical changes in ATs in individuals with and without plantar fasciitis (PF). The purposes were as follows: (1) to evaluate the passive stiffness of three regions of the AT which defined as 0 (AT0 cm), 3 (AT3 cm), and 6 cm (AT6 cm) above the calcaneal tuberosity in participants with and without PF, (2) to investigate the interplay between the passive stiffness in patients with PF and pain, (3) to detect optimal cut-off points of stiffness of the AT in assessing individuals with chronic PF, and (4) to determine the correlation between the plantar fascia thickness (PFT) and pain. This cross-sectional study included 40 participants (mean age = 51 ± 13 years). When the ankle was in a relaxed position, patients with PF experienced increased passive stiffness in AT0 cm (p = 0.006) and AT3 cm (P = 0.003), but not in the neutral position. Significant correlations were observed between pain and stiffness of AT (AT0 cm r = 0.489, P = 0.029; AT3 cm r = 487, P = 0.030; AT6 cm r = 0.471, P = 0.036), but not in the PFT (P = 0.557). Optimal cut-off stiffness was AT (452 kPa) in the relaxed ankle position. The plantar fascia of patients with PF was significantly thicker than that of the controls (P < 0.001). Findings from the present study demonstrate that tendon stiffness is a good indicator of the clinical situation of patients with PF. Monitoring passive tendon stiffness may provide additional information to assess severity of the condition and guide therapeutic. The treatment programs for PF should also be tailored to the distal AT, as conventional therapy might not be targeted to tight tendons.

Humidity mediated performance and material properties of orb weaving spider adhesive droplets

Capture thread glue droplets retain insects that strike an orb web and are key to the success of over 4,600 described spider species. Each droplet is a self-assembling adhesive system whose emergent biomechanical properties are centered on its viscoelastic, protein core. This bioadhesive is dependent on its surrounding hygroscopic aqueous layer for hydration and chemical conditioning. Consequently, a droplet's water content and adhesive performance track environmental humidity. We tested the hypothesis that natural selection has tuned a droplet's adhesive performance and material properties to a species’ foraging humidity. At 55% relative humidity (RH) the adhesive properties of 12 species ranged from that of PEG-based hydrogels to that of silicone rubber, exhibiting a 1088-fold inter-specific difference in stiffness (0.02-21.76 MPa) and a 147-fold difference in toughness (0.14-20.51 MJ/m3). When tested over a 70% RH range, droplet extension lengths per protein core volume peaked at lower humidities in species from exposed, low humidity habitats, and at higher humidities in nocturnal species and those found in humid habitats. However, at the RH's where these species’ maximum extension per protein volume indices were observed, the stiffness of most species’ adhesive did not differ, documenting that selection has tuned elastic modulus by adjusting droplet hygroscopicity. This inverse relationship between droplet hygroscopicity and a species’ foraging humidity ensures optimal adhesive stiffness. By characterizing the humidity responsiveness and properties of orb spider glue droplets, our study also profiles the range of its biomimetic potential. Statement of significanceOver 4,600 described species of orb weaving spider rely on tiny glue droplets in their webs to retain insect that the web intercepts. The aqueous layer that covers each droplet's core allows this adhesive to remain pliable and to stretch as an insect struggles to escape. The aqueous solution also attracts water from the air, causing the glue droplet's performance to change with humidity. By characterizing the droplet extensions and adhesive material properties of twelve species at relative humidities between of 20 and 90%, this study examined how this unique adhesive system responds to its environment and how it is tuned to the humidity of a species’ habitat.

Individual stiffness optimization of dorsal leaf spring ankle\u2013foot orthoses in people with calf muscle weakness is superior to standard bodyweight-based recommendations

BackgroundIn people with calf muscle weakness, the stiffness of dorsal leaf spring ankle–foot orthoses (DLS-AFO) needs to be individualized to maximize its effect on walking. Orthotic suppliers may recommend a certain stiffness based on body weight and activity level. However, it is unknown whether these recommendations are sufficient to yield the optimal stiffness for the individual. Therefore, we assessed whether the stiffness following the supplier’s recommendation of the Carbon Ankle7 (CA7) dorsal leaf matched the experimentally optimized AFO stiffness.MethodsThirty-four persons with calf muscle weakness were included and provided a new DLS-AFO of which the stiffness could be varied by changing the CA7® (Ottobock, Duderstadt, Germany) dorsal leaf. For five different stiffness levels, including the supplier recommended stiffness, gait biomechanics, walking energy cost and speed were assessed. Based on these measures, the individual experimentally optimal AFO stiffness was selected.ResultsIn only 8 of 34 (23%) participants, the supplier recommended stiffness matched the experimentally optimized AFO stiffness, the latter being on average 1.2 ± 1.3 Nm/degree more flexible. The DLS-AFO with an experimentally optimized stiffness resulted in a significantly lower walking energy cost (− 0.21 ± 0.26 J/kg/m, p < 0.001) and a higher speed (+ 0.02 m/s, p = 0.003). Additionally, a larger ankle range of motion (+ 1.3 ± 0.3 degrees, p < 0.001) and higher ankle power (+ 0.16 ± 0.04 W/kg, p < 0.001) were found with the experimentally optimized stiffness compared to the supplier recommended stiffness.ConclusionsIn people with calf muscle weakness, current supplier’s recommendations for the CA7 stiffness level result in the provision of DLS-AFOs that are too stiff and only achieve 80% of the reduction in energy cost achieved with an individual optimized stiffness. It is recommended to experimentally optimize the CA7 stiffness in people with calf muscle weakness in order to maximize treatment outcomes.Trial registration Nederlands Trial Register 5170. Registration date: May 7th 2015. http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5170.

Reducing the metabolic energy of walking and running using an unpowered hip exoskeleton

BackgroundWalking and running are the most common means of locomotion in human daily life. People have made advances in developing separate exoskeletons to reduce the metabolic rate of walking or running. However, the combined requirements of overcoming the fundamental biomechanical differences between the two gaits and minimizing the metabolic penalty of the exoskeleton mass make it challenging to develop an exoskeleton that can reduce the metabolic energy during both gaits. Here we show that the metabolic energy of both walking and running can be reduced by regulating the metabolic energy of hip flexion during the common energy consumption period of the two gaits using an unpowered hip exoskeleton.MethodsWe analyzed the metabolic rates, muscle activities and spatiotemporal parameters of 9 healthy subjects (mean ± s.t.d; 24.9 ± 3.7 years, 66.9 ± 8.7 kg, 1.76 ± 0.05 m) walking on a treadmill at a speed of 1.5 m s−1 and running at a speed of 2.5 m s−1 with different spring stiffnesses. After obtaining the optimal spring stiffness, we recruited the participants to walk and run with the assistance from a spring with optimal stiffness at different speeds to demonstrate the generality of the proposed approach.ResultsWe found that the common optimal exoskeleton spring stiffness for walking and running was 83 Nm Rad−1, corresponding to 7.2% ± 1.2% (mean ± s.e.m, paired t-test p < 0.01) and 6.8% ± 1.0% (p < 0.01) metabolic reductions compared to walking and running without exoskeleton. The metabolic energy within the tested speed range can be reduced with the assistance except for low-speed walking (1.0 m s−1). Participants showed different changes in muscle activities with the assistance of the proposed exoskeleton.ConclusionsThis paper first demonstrates that the metabolic cost of walking and running can be reduced using an unpowered hip exoskeleton to regulate the metabolic energy of hip flexion. The design method based on analyzing the common energy consumption characteristics between gaits may inspire future exoskeletons that assist multiple gaits. The results of different changes in muscle activities provide new insight into human response to the same assistive principle for different gaits (walking and running).

Simulation-based biomechanical assessment of unpowered exoskeletons for running

Due to the complexity and high degrees of freedom, the detailed assessment of human biomechanics is necessary for the design and optimization of an effective exoskeleton. In this paper, we present full kinematics, dynamics, and biomechanics assessment of unpowered exoskeleton augmentation for human running gait. To do so, the considered case study is the assistive torque profile of I-RUN. Our approach is using some extensive data-driven OpenSim simulation results employing a generic lower limb model with 92-muscles and 29-DOF. In the simulation, it is observed that exoskeleton augmentation leads to 4.62% metabolic rate reduction for the stiffness coefficient of alpha ^*=0.6. Moreover, this optimum stiffness coefficient minimizes the biological hip moment by 26%. The optimum stiffness coefficient (alpha ^*=0.6) also reduces the average force of four major hip muscles, i.e., Psoas, Gluteus Maximus, Rectus Femoris, and Semimembranosus. The effect of assistive torque profile on the muscles’ fatigue is also studied. Interestingly, it is observed that at alpha ^{#}=0.8, both all 92 lower limb muscles’ fatigue and two hip major mono-articular muscles’ fatigue have the maximum reduction. This result re-confirm our hypothesis that ”reducing the forces of two antagonistic mono-articular muscles is sufficient for involved muscles’ total fatigue reduction.” Finally, the relation between the amount of metabolic rate reduction and kinematics of hip joint is examined carefully where for the first time, we present a reliable kinematic index for prediction of the metabolic rate reduction by I-RUN augmentation. This index not only explains individual differences in metabolic rate reduction but also provides a quantitative measure for training the subjects to maximize their benefits from I-RUN.

The effect of surgeon-controlled variables on construct stiffness in lateral locked plating of distal femoral fractures

BackgroundNonunion following treatment of supracondylar femur fractures with lateral locked plates (LLP) has been reported to be as high as 21 %. Implant related and surgeon-controlled variables have been postulated to contribute to nonunion by modulating fracture-fixation construct stiffness. The purpose of this study is to evaluate the effect of surgeon-controlled factors on stiffness when treating supracondylar femur fractures with LLPs:Does plate length affect construct stiffness given the same plate material, fracture working length and type of screws?Does screw type (bicortical locking versus bicortical nonlocking or unicortical locking) and number of screws affect construct stiffness given the same material, fracture working length, and plate length?Does fracture working length affect construct stiffness given the same plate material, length and type of screws?Does plate material (titanium versus stainless steel) affect construct stiffness given the same fracture working length, plate length, type and number of screws?MethodsMechanical study of simulated supracondylar femur fractures treated with LLPs of varying lengths, screw types, fractureworking lenghts, and plate/screw material. Overall construct stiffness was evaluated using an Instron hydraulic testing apparatus.ResultsStiffness was 15 % higher comparing 13-hole to the 5-hole plates (995 N/mm849N vs. /mm, p = 0.003). The use of bicortical nonlocking screws decreased overall construct stiffness by 18 % compared to bicortical locking screws (808 N/mm vs. 995 N/mm, p = 0.0001). The type of screw (unicortical locking vs. bicortical locking) and the number of screws in the diaphysis (3 vs. 10) did not appear to significantly influence construct stiffness (p = 0.76, p = 0.24). Similarly, fracture working length (5.4 cm vs. 9.4 cm, p = 0.24), and implant type (titanium vs. stainless steel, p = 0.12) did also not appear to effect stiffness.DiscussionUsing shorter plates and using bicortical nonlocking screws (vs. bicortical locking screws) reduced overall construct stiffness. Using more screws, using unicortical locking screws, increasing fracture working length and varying plate material (titanium vs. stainless steel) does not appear to significantly alter construct stiffness. Surgeons can adjust plate length and screw types to affect overall fracture-fixation construct stiffness; however, the optimal stiffness to promote healing remains unknown.

Increased Construct Stiffness With Meniscal Repair Sutures and Devices Increases the Risk of Cheese-Wiring During Biomechanical Load-to-Failure Testing.

Background:Cheese-wiring, the suture that cuts through the meniscus, is a well-known issue in meniscal repair. So far, contributing factors are neither fully understood nor sufficiently studied.Hypothesis/Purpose:To investigate whether the construct stiffness of repair sutures and devices correlates with suture cut-through (cheese-wiring) during load-to-failure testing.Study Design:Controlled laboratory study.Methods:In 131 porcine menisci, longitudinal bucket-handle tears were repaired using either inside-out sutures (n = 66; No. 0 Ultrabraid, 2-0 Orthocord, 2-0 FiberWire, and 2-0 Ethibond) or all-inside devices (n = 65; FastFix360, Omnispan, and Meniscal Cinch). After cyclic loading, load-to-failure testing was performed. The mode of failure and construct stiffness were recorded. A receiver operating characteristic curve analysis was performed to define the optimal stiffness threshold for predicting meniscal repair failure by cheese-wiring. The 2-tailed t test and analysis of variance were used to test significance.Results:Loss of suture fixation was the most common mode of failure in all specimens (58%), except for the Omnispan, which failed most commonly because of anchor pull-through. The Omnispan demonstrated the highest construct stiffness (30.8 ± 3.5 N/mm), whereas the Meniscal Cinch (18.0 ± 8.8 N/mm) and Ethibond (19.4 ± 7.8 N/mm) demonstrated the lowest construct stiffness. The Omnispan showed significantly higher stiffness compared with the Meniscal Cinch (P < .001) and Ethibond (P = .02), whereas the stiffness of the Meniscal Cinch was significantly lower compared with that of the FiberWire (P = .01), Ultrabraid (P = .04), and FastFix360 (P = .03). While meniscal repair with a high construct stiffness more often failed by cheese-wiring, meniscal repair with a lower stiffness failed by loss of suture fixation, knot slippage, or anchor pull-through. Meniscal repair with a stiffness >26.5 N/mm had a 3.6 times higher risk of failure due to cheese-wiring during load-to-failure testing (95% CI, 1.4-8.2; P < .0001).Conclusion:Meniscal repair using inside-out sutures and all-inside devices with a higher construct stiffness (>26.5 N/mm) was more likely to fail through suture cut-through (cheese-wiring) than that with a lower stiffness (≤26.5 N/mm).Clinical Relevance:This is the first study investigating the impact of construct stiffness on meniscal repair failure by suture cut-through (cheese-wiring).

An enhanced reduced-order model based optimization method for buckling and postbuckling performances of variable stiffness composite plates

The great potential of variable stiffness laminates in maximizing buckling load is obvious over straight fiber laminates, however the optimum design of such VAT laminates which has much more design variables and larger computational efforts, is still a challenge even for the modern computational method and capability. In addition, the postbuckling performance and the correlations with buckling resistance still need to be further studied for VAT laminates. This work proposes an enhanced reduced-order model based on the improved Koiter perturbation theory for buckling and postbuckling analysis of variable stiffness composite plates. The VAT laminas composed by “two-segment” fibers and “four-segment” fibers are considered, respectively, in construction of the reduced-order finite element model. The nonlinear prediction for initial postbuckling response of VAT laminate can be achieved, by solving the small-scaled reduced-order model. The nonlinear buckling load, postbuckling stiffness and postbuckling stiffness residual factor, are accurately and efficiently extracted from the initial postbuckling predictor, and then subsequently to be selected as inputs to the GA based optimization process for the design of VAT laminates. Extensive numerical investigations validate that the proposed method can find a combination of several varied angle fiber layers with constant thicknesses such that the combination results in an optimal stiffness distribution and provides a more favorable structural performance in both buckling and postbuckling regime for different demands of structure design.

A virtual joint method of analytical form for parallel manipulators

Oriented towards the stiffness optimization of parallel manipulators, a stiffness modeling method based on subspace analysis was proposed. The paper revealed the “shielding effect” of passive joints, i.e. shielding the partial local stiffness of a mechanism on Cartesian space, and accordingly brought forward the concept of Effective Stiffness Tensor (EST), which was then obtained by introducing the orthogonal projector. The method allows a stiffness model of analytical form as well as high computation efficiency, which makes it suitable for applications in the stiffness optimization of parallel manipulators. Proposed method had been applied to the parallel alignment mechanism in China’s large space telescope and verified by dynamic experiments.

PARAMETERS OPTIMIZATION OF A DYNAMIC VIBRATION ABSORBER WITH INERTER AND GROUNDED STIFFNESS

Most mechanical vibrations are detrimental that not only generate noise but also reduce the service life and operating performance of the equipment. As two common components, grounded stiffness and inerter can change the natural frequency of the system, which has good effect in the field of vibration control. However, most of the current research only focuses on the impact of a single component on the system, and the vibration absorber is gradually difficult to meet the growth of performance demand for vibration control. Based on the typical Voigt-type dynamic vibration absorber, a novel dynamic vibration absorber model with inerter and grounded stiffness is presented. The optimal parameters of the presented model are studied in detail, and the analytical solution of the optimal design formula is derived. First of all, the motion differential equation of the two degree-of-freedom system is established through Newton's second law, and from the system analytical solution it is found that the system has three fixed points unrelated to the damping ratio. The optimal frequency ratio of the dynamic vibration absorber is obtained based on the fixed-point theory. When screening the optimal grounded stiffness ratio, it is found that the inappropriate inerter coefficient will cause the system to generate instability. Then the best working range of the inerter is derived, and finally the optimal grounded stiffness ratio and approximate optimal damping ratio are also obtained. The working condition when the inerter coefficient is not within the best range is discussed, and the suggestions in practical application are given. The correctness of the analytical solution is verified by numerical simulation. Compared with other dynamic vibration absorbers under harmonic and random excitations, it is verified that the presented DVA can greatly reduce the amplitude of the primary system, widen the vibration reduction frequency band, and provide a theoretical basis for the design of new type of DVAs.

Microstructural topology optimization for patch-based sandwich panel with desired in-plane thermal expansion and structural stiffness

Apart from the lightweight and excellent mechanical properties, sandwich panels can be endowed with tailorable in-plane coefficient of thermal expansion (CTE) through an elaborate design of periodic face-sheets. However, albeit that the microstructural topology of their periodic face-sheets promises unique thermal expansion behaviors, it may also bring significant influences to the structural stiffness of sandwich panels. In this study, we apply the topology optimization method to design face-sheet microstructures to enable the sandwich panels to possess desired in-plane CTEs, lightweight and benign mechanical properties, simultaneously. By introducing the patch-based cell as initial configuration, the existing thermally bending adjustment mechanism for thermal deformation control is integrated to the process of topology optimization. The entire topology optimization process including the equivalent mechanical properties prediction and the sensitivity computation is performed within an in-house program coupled with commercial finite element analysis software. To this end, a matching numerical sensitivity analysis method to extract sensitivities straightforwardly from software’s output is also developed on the basis of asymptotic homogenization method. Three types of specific optimization problems in terms of different objective functions and constraint conditions are proposed, solved, and studied, namely, in-plane zero thermal expansion combining with maximum stiffness, the other for in-plane zero thermal expansion optimal specific stiffness, and minimizing in-plane isotropic thermal expansion. Some specific resulting topologies, microstructural features, and design details are subsequently obtained. In particular, the current strategy of integrating effective mechanism and topological technology can be extended to design more microstructures for simultaneously tailorable CTE and high mechanical performance by replacing present thermal deformation control mechanism with others.

Optimal Stiffness Design of Self-Piercing Riveting's C-Frame for Multimaterial Joining

Optimal Stiffness Design of Self-Piercing Riveting's C-Frame for Multimaterial Joining

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing

BackgroundGlioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive and associated with altered N-glycosylation pattern. Glycocalyx thickness modulates integrins mechanosensing, but details remain elusive and glycosylation enzymes involved are unknown. Here, we studied the association between matrix stiffness modulation, GSC migration and MGAT5 induced N-glycosylation in fibrillar 3D context.MethodTo mimic the extracellular matrix fibrillar microenvironments, we designed 3D-ex-polyacrylonitrile nanofibers scaffolds (NFS) with adjustable stiffnesses by loading multiwall carbon nanotubes (MWCNT). GSCs neurosphere were plated on NFSs, allowing GSCs migration and MGAT5 was deleted using CRISPR-Cas9.ResultsWe found that migration of GSCs was maximum at 166 kPa. Migration rate was correlated with cell shape, expression and maturation of focal adhesion (FA), Epithelial to Mesenchymal Transition (EMT) proteins and (β1,6) branched N-glycan binding, galectin-3. Mutation of MGAT5 in GSC inhibited N-glycans (β1–6) branching, suppressed the stiffness dependence of migration on 166 kPa NFS as well as the associated FA and EMT protein expression.ConclusionMGAT5 catalysing multibranched N-glycans is a critical regulators of stiffness induced invasion and GSCs mechanotransduction, underpinning MGAT5 as a serious target to treat cancer.

Design of model-free reinforcement learning control for tunable vibration absorber system based on magnetorheological elastomer

This paper proposes a novel model-free reinforcement learning (RL) for vibration control of a magnetorheological elastomer (MRE)-based application. Because the modeling of the MRE stiffness is nonlinear and time-varying depending on various environmental factors, this paper approached the MRE control issue via a model-free learning based method. In this study, an RL model is designed for the MRE-based tunable vibration absorber (TVA) which can control the optimal stiffness of MRE to maximize the vibration suppression. The designed RL algorithm continuously learns and updates the optimal control input of the MRE stiffness adaptively to the dynamic environment without using any prior knowledge of the MRE modeling. From analyzing the mechanism of MRE TVA, the RL algorithm and parameters are carefully designed for a high vibration performance. Also, this study proposed several ideas to make the RL model simpler and converge at a high rate. The experiments confirmed that the proposed RL model showed a rapid convergence to the optimal policy which could minimize the vibration level with respect to the dynamic excitation disturbance. Results showed that the RL model had a similar performance as the conventional tuning method and suppressed the vibration level as much as 57% compared to the one without the controller. Also, the proposed RL algorithm was able to estimate the actual dynamics of the MRE TVA by learning from the environment. Thus, this study showed the feasibility of implementing a model-free RL model to realize an adaptive controller for applications based on highly nonlinear MRE.

Bidirectional evolutionary optimization design of material stiffness for the uniformity of the contact stress

An investigation into the material stiffness design for enhancing the uniformity of the contact stress is conducted in this paper. A bidirectional evolutionary optimization design approach for interface material stiffness is developed, in which the standard deviation of the contact stress is defined as the objective function and the Young's modulus is treated as the design variable. A design case of a single bolted joint verifies that the proposed bidirectional material stiffness optimization approach can effectively improve the uniformity of the contact stress. A region-averaging treatment is proposed as the post-processing of the optimized Young's modulus distribution to make the optimized structure more manufacturable. The capabilities for homogenizing the contact stress distribution with various geometry sizes are addressed. A comparison study with the interface shape optimization indicates that with nearly the same improvement of the standard deviation of the contact stress, the material stiffness design around the contact region is more effective on enlarging the effective contact area and is much more computationally efficient than the interface shape optimization.