Through the analysis of the relationship between logistics and economy, energy and environment, a mathematical model for the path optimization of multiple logistics distribution centres for energy conservation and emission reduction in logistics is established. According to the characteristics of the problem, a genetic algorithm is constructed to solve the problem, and the path optimization problem of multiple logistics distribution centres is integrated and solved by a mathematical model. This thesis establishes a mathematical model of the path optimization problem of multiple logistics distribution centres. This article proposes the concept of invalid genes, which is not limited to making every gene in an individual must be expressed, thus enhancing the flexibility of coding. Simulation experiments prove the effectiveness and operability of the method.