Human civilization has been intertwined with sericulture—the art and science of producing silk for centuries. The application of nanotechnology to sericulture techniques has created new opportunities to improve the quantity, quality and use of silk in recent decades. This abstract examines the numerous applications of nanotechnology in sericulture, with particular attention on how it affects the quality of silk fibers, the procedures involved in producing silk and the creation of cutting-edge materials derived from silk. By providing comprehensive control over the properties of silk at the molecular and atomic levels, nanotechnology, defined as the manipulation of matter at the nano scale, has completely transformed the silk industry. Improving the health and growth of silkworms is one of the main application areas. Silver nanoparticles, for example have been used to fight illnesses and strengthen silkworm’s immune systems, boosting the insect’s resilience against illness and optimizing silk yield. Furthermore, silk fiber quality has increased largely in substantial measure by nanotechnology. The mechanical, thermal and optical characteristics of silk fibers have been altered by researchers by adding nanoparticles during the spinning process. For example, adding nanoparticles to silk can increase its tensile strength, making it more durable and appropriate for a variety of industrial uses. Similarly, silk can be given antibacterial qualities by adding nanoscale compounds, increasing its shelf life and possible uses in medical textiles. Furthermore, the production of sophisticated silk-based materials with distinctive functions has been made easier by nanotechnology. Nanocomposites, which consist of nanoparticles embedded in silk matrices, have unique characteristics like improved electrical conductivity, controlled drug release, and greater biocompatibility. Silk-based materials have emerged as a result of these developments, finding use both in wearable electronics and biomedical devices.