To verify whether 3D surface deviation analysis software can detect the surface changes of composite veneered polyetheretherketone posterior crowns following wear simulation compared to optical digital profilometry. Twenty dental crowns, fabricated from CAD-CAM polyetheretherketone (PEEK) and veneered with high impact polymer composite (HIPC), were subjected to wear test (50N, 5/55°C; 120,000 chewing cycles). Optical digital profilometry and 3D surface deviation using Geomagic design X software was used before and after the wear test to measure volumetric wear loss (mm3 ). The data were statistically analyzed with Wilcoxon signed-rank test to compare the two methodologies. The significance level was set at p ≤ 0.05. There was no statistically significant difference between the two assessment methods (p-value = 0.075, Effect size = 0.854). Regarding the optical digital profilometry analysis, HIPC veneered PEEK crowns showed 0.01686 (0.018-0.02155) mm3 as a median volumetric wear loss value. While the crowns analyzed by 3D surface deviation showed -0.0398 (-0.0913 to -0.0042) mm3 as a median volumetric loss value (p-value = 0.075, Effect size = 0.854). In addition, there was no statistically significant correlation between wear measurements by optical digital profilometry and 3D surface deviation analyses (ρ = -0.177, p-value = 0.685). There was no significant difference or correlation between optical digital profilometry and 3D surface deviation analyses for volumetric wear loss of veneered PEEK crowns.