Optical Detection Scheme Research Articles

Characterization of metal oxide gas sensors via optical techniques

Metal oxide (MOX) sensors are increasingly gaining attention in analytical applications. Their fundamental operation principle is based on conversion reactions of selected molecular species at their semiconducting surface. However, the exact turnover of analyte gas in relation to the concentration has not been investigated in detail to date. In the present study, two optical sensing techniques—luminescence quenching for molecular oxygen and infrared spectroscopy for carbon dioxide and methane—have been coupled for characterizing the behavior of an example semiconducting MOX methane gas sensor integrated into a recently developed low-volume gas cell. Thereby, oxygen consumption during MOX operation as well as the generation of carbon dioxide from the methane conversion reaction could be quantitatively monitored. The latter was analyzed via a direct mid-infrared gas sensor system based on substrate-integrated hollow waveguide (iHWG) technology combined with a portable Fourier transform infrared spectrometer, which has been able to not only detect the amount of generated carbon dioxide but also the consumption of methane during MOX operation. Hence, a method based entirely on direct optical detection schemes was developed for characterizing the actual signal generating processes—here for the detection of methane—via MOX sensing devices via near real-time online analysis.Graphical

Toward Diffusion Measurements of Colloidal Nanoparticles in Biological Environments by Nuclear Magnetic Resonance.

Protein corona formation on the surface of nanoparticles (NPs) is observed in situ by measuring diffusion coefficients of the NPs under the presence of proteins with a 19 F nuclear magnetic resonance (NMR) based methodology. Formation of a protein corona reduces the diffusion coefficient of the NPs, based on an increase in their effective hydrodynamic radii. With this methodology it is demonstrated that the apparent dissociation constant of protein-NP complexes may vary over at least nine orders of magnitude for different types of proteins, in line with the Vroman effect. Using this methodology, the interaction between one type of protein and one type of nanoparticle can be studied quantitatively. Due to the NMR-based detection, this methodology has no interference by absorption/scattering effects, by which optical detection schemes are affected. By using the potential of the NMR chemical shift, the detection of multiple 19 F signals simultaneously opens the possibility to study the diffusion of several NPs at the same time. The 19 F labeling of the NPs has negligible effect on their acute toxicity and moderate effect on NPs uptake by cells.

Conformable Nanowire-in-Nanofiber Hybrids for Low-Threshold Optical Gain in the Ultraviolet.

The miniaturization of diagnostic devices that exploit optical detection schemes requires the design of light sources combining small size, high performance for effective excitation of chromophores, and mechanical flexibility for easy coupling to components with complex and nonplanar shapes. Here, ZnO nanowire-in-fiber hybrids with internal architectural order are introduced, exhibiting a combination of polarized stimulated emission, low propagation losses of light modes, and structural flexibility. Ultrafast transient absorption experiments on the electrospun material show optical gain which gives rise to amplified spontaneous emission with a threshold lower than the value found in films. These systems are highly flexible and can conveniently conform to curved surfaces, which makes them appealing active elements for various device platforms, such as bendable lasers, optical networks, and sensors, as well as for application in bioimaging, photo-cross-linking, and optogenetics.

Multivariate Analysis of Photoacoustic Spectra for the Detection of Short-Chained Hydrocarbon Isotopologues.

We report, to our knowledge, the first optical detection scheme for short-chained hydrocarbon isotopologues. The sensor system is based on photoacoustic spectroscopy (PAS). Two continuous wave, thermoelectrically cooled, distributed feedback interband cascade lasers (DFB-ICLs) with emission wavelengths around 3.33 and 3.38 μm, respectively, served as light sources. The investigations comprised the main stable carbon isotopologues of methane (12CH4, 13CH4), ethane (12CH3-12CH3, 13CH3-12CH3, 13CH3-13CH3), and propane (12CH3-12CH2-12CH3, 13CH3-12CH2-12CH3). They were selected because of their importance for numerous applications from climate and planetary research to natural gas exploration. Multiple measurements of single components in nitrogen and synthetic mixtures were conducted at room temperature and atmospheric pressure. Depending on the investigated hydrocarbon isotopologue, detection limits ranging from 0.043 ppmv to 3.4 ppmv were achieved. For a selective concentration determination, multivariate analysis (MVA) was applied. Partial least-squares regression (PLSR) was used to calculate concentrations from the PA spectra. The implementation of MVA has shown that the PA setup in principle works reliably and that the selective concentration determination of short-chained hydrocarbon isotopologues is possible.

Mixed MUD-RF/FSO Two Way Dcode and Forward Relaying Networks in the Presence of Co-Channel Interference

In this research work, mixed radio frequency (RF)/free-space optical (FSO) decode-and-forward (DF) two-way relaying (TWR) system is investigated in the presence of interference. In order to improve the performance of the RF link, multiuser diversity (MUD) scheme has been implemented. The multiple RF users undergo Nakagami-m distributed fading. The atmospheric turbulence on the FSO link is assumed to follow the double generalized Gamma (D-GG) scintillation model. The model on the FSO link considers two kinds of optical detection schemes, i.e., intensity modulation/direct detection (IM/DD) and coherent demodulation scheme, and also includes the effect of pointing errors. Furthermore, multiple co-channel interferers (CCIs) at the relay node are assumed to undergo Nakagami-m fading. For the considered TWR system, exact closed-loop expressions for the outage probability and bit error rate (BER) have been derived. These exact closed-form expressions have been further simplified for the case of high signal-to-noise (SNR) to derive the asymptotic expressions for the outage probability and BER of the considered system. Finally, the analytical framework developed in the research work has been validated using numerical examples.

Evaluating compositional effects on the laser-induced combustion and shock velocities of Al/Zr-based composite fuels

Laser-induced air shock from energetic materials (LASEM) is a laboratory-scale method for assessing the microsecond and millisecond timescale performance of conventional military explosives. The technique has been combined with optical emission detection schemes to evaluate energy release during detonation and post-detonation timescales from the combustion of metal powders and mixtures of metal powders and explosives. Recently, Al/Zr reactive composite powders have been synthesized via high energy ball milling with the aim of decreasing ignition thresholds while simultaneously increasing overall combustion efficiency and burn time. Here, we utilize LASEM to evaluate micron-sized 3Al:2Zr, Al:Zr, and Al:3Zr fuel powders and compare their behavior to micron-sized Al powder, a commonly used explosive additive. We observed a rapid ignition of Al/Zr powders instead of the delayed ignition of the secondary deflagration cloud that is observed for pure Al. The composites also demonstrated longer burn times compared to Al particles of similar size. We also observed enhanced laser-induced shock velocities for the composite samples, implying increased energy release in the microsecond time regime compared to Al. In addition, we present LASEM data using Al/Zr mixed with trinitrotoluene (TNT), and associated CHEETAH calculations. As expected, adding pure Al to TNT lowers the laser-induced shock velocity, and we observe a further decrease of this velocity when using composite additives. The complex interplay of the metals with each other and the TNT reaction products is yet to be fully understood.

Performance of grey‐coded IQM‐based optical modulation formats on high‐speed long‐haul optical communication link

In this article the performance of grey-coded advanced optical modulation formats is evaluated on a single-channel high-speed long-haul optical communication link and are compared to the respective differential-coded modulation formats. Polarisation division multiplexed optical in-phase quadrature modulator (IQM) structure and homodyne detection scheme are used to realise 100 Gbps quadrature phase-shift keying (QPSK), 120 Gbps 16-ary quadrature amplitude modulation (16-QAM), 360 Gbps 32-QAM and 480 Gbps 64-QAM modulation formats. Advanced digital signal processing unit with various pre-processing and recovery stages such as direct current blocking, normalisation, low-pass Bessel filter, resampling, quadrature imbalance compensation, chromatic dispersion compensation, non-linear compensation, timing recovery, adaptive equalisation, down-sampling, frequency offset estimation, and carrier phase estimation is used at the receiving end to compensate for signal impairments during propagation. Maximum transmission distances of 7200, 1050, 560, and 360 km have been achieved at an acceptable bit error rate for QPSK, 16-QAM, 32-QAM, and 64-QAM, respectively. The grey-coded systems outperformed the differential-coded systems regarding optical signal-to-noise ratio requirement, receiver sensitivity, and transmission distance.

Optical Detection of Single-Electron Tunneling into a Semiconductor Quantum Dot.

The maximum information of a dynamic quantum system is given by real-time detection of every quantum event, where the ultimate challenge is a stable, sensitive detector with high bandwidth. All physical information can then be drawn from a statistical analysis of the time traces. We demonstrate here an optical detection scheme based on the time-resolved resonance fluorescence on a single quantum dot. Single-electron resolution with high signal-to-noise ratio (4σ confidence) and high bandwidth of 10kHz make it possible to record the individual quantum events of the transport dynamics. Full counting statistics with factorial cumulants gives access to the nonequilibrium dynamics of spin relaxation of a singly charged dot (γ_{↑↓}=3 ms^{-1}), even in an equilibrium transport measurement.

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium.

The integration of microfluidics with advanced biosensor technologies offers tremendous advantages such as smaller sample volume requirement and precise handling of samples and reagents, for developing affordable point-of-care testing methodologies that could be used in hospitals for monitoring patients. However, the success and popularity of point-of-care diagnosis lies with the generation of instantaneous and reliable results through in situ tests conducted in a painless, non-invasive manner. This work presents the development of a simple, hybrid integrated optical microfluidic biosensor for rapid detection of analytes in test samples. The proposed biosensor works on the principle of colorimetric optical absorption, wherein samples mixed with suitable chromogenic substrates induce a color change dependent upon the analyte concentration that could then be detected by the absorbance of light in its path length. This optical detection scheme has been hybrid integrated with an acoustofluidic micromixing unit to enable uniform mixing of fluids within the device. As a proof-of-concept, we have demonstrated the real-time application of our biosensor format for the detection of potassium in whole saliva samples. The results show that our lab-on-a-chip technology could provide a useful strategy in biomedical diagnoses for rapid analyte detection towards clinical point-of-care testing applications.

Experimental investigation of linear-optics-based quantum target detection

The development of new techniques to improve measurements is crucial for all sciences. By employing quantum systems as sensors to probe some physical property of interest allows the application of quantum resources, such as coherent superpositions and quantum correlations, to increase measurement precision. Here we experimentally investigate a scheme for quantum target detection based on linear optical measurment devices, when the object is immersed in unpolarized background light. By comparing the quantum (polarization-entangled photon pairs) and the classical (separable polarization states), we found that the quantum strategy provides us an improvement over the classical one in our experiment when the signal to noise ratio is greater than 1/40, or about 16dB of noise. This is in constrast to quantum target detection considering non-linear optical detection schemes, which have shown resilience to extreme amounts of noise. A theoretical model is developed which shows that, in this linear-optics context, the quantum strategy suffers from the contribution of multiple background photons. This effect does not appear in our classical scheme. By improving the two-photon detection electronics, it should be possible to achieve a polarization-based quantum advantage for a signal to noise ratio that is close to 1/400 for current technology.

Quantum regression theorem for out-of-time-ordered correlation functions

We derive an extension of the quantum regression theorem to calculate out-of-time-order correlation functions in Markovian open quantum systems. While so far mostly being applied in the analysis of many-body physics, we demonstrate that out-of-time-order correlation functions appear naturally in optical detection schemes with interferometric delay lines, and we apply our extended quantum regression theorem to calculate the non-trivial photon counting fluctuations in split and recombined signals from a quantum light source.

Novel optical twin-SSB detection scheme using an electric butterfly operation

Novel optical twin-SSB detection scheme using an electric butterfly operation

Observation of Brillouin optomechanical strong coupling with an 11 GHz mechanical mode

Achieving cavity-optomechanical strong coupling with high-frequency phonons provides a rich avenue for quantum technology development including quantum state-transfer, memory, and transduction, as well as enabling several fundamental studies of macroscopic phononic degrees-of-freedom. Reaching such coupling with GHz mechanical modes however has proved challenging, with a prominent hindrance being material- and surface-induced-optical absorption in many materials. Here, we circumvent these challenges and report the observation of optomechanical strong coupling to a high frequency (11 GHz) mechanical mode of a fused-silica whispering-gallery microresonator via the electrostrictive Brillouin interaction. Using an optical heterodyne detection scheme, the anti-Stokes light backscattered from the resonator is measured and normal-mode splitting and an avoided crossing are observed in the recorded spectra, providing unambiguous signatures of strong coupling. The optomechanical coupling rate reaches values as high as $G/2\pi = 39 \ \text{MHz}$ through the use of an auxiliary pump resonance, where the coupling dominates both the optical ($\kappa/2\pi = 3 \ \text{MHz}$) and the mechanical ($\gamma_\text{m}/2\pi = 21 \ \text{MHz}$) amplitude decay rates. Our findings provide a promising new approach for optical quantum control using light and sound.

Label-Free Optical Detection of DNA Translocations through Plasmonic Nanopores.

Solid-state nanopores are single-molecule sensors that hold great potential for rapid protein and nucleic-acid analysis. Despite their many opportunities, the conventional ionic current detection scheme that is at the heart of the sensor suffers inherent limitations. This scheme intrinsically couples signal strength to the driving voltage, requires the use of high-concentration electrolytes, suffers from capacitive noise, and impairs high-density sensor integration. Here, we propose a fundamentally different detection scheme based on the enhanced light transmission through a plasmonic nanopore. We demonstrate that translocations of single DNA molecules can be optically detected, without the need of any labeling, in the transmitted light intensity through an inverted-bowtie plasmonic nanopore. Characterization and the cross-correlation of the optical signals with their electrical counterparts verify the plasmonic basis of the optical signal. We demonstrate DNA translocation event detection in a regime of driving voltages and buffer conditions where traditional ionic current sensing fails. This label-free optical detection scheme offers opportunities to probe native DNA–protein interactions at physiological conditions.

Emerging technologies for optical spectral detection of reactive oxygen species.

This review surveys recent advances in optical spectral detection of reactive oxygen species (ROS), particularly singlet oxygen, superoxide, hydroxyl radical, and hydrogen peroxide. Advances using nanoparticles and self-organizing nanostructures as well as optical detection schemes are included. Measurements using plasmonic, luminescent, photocatalytic, or self-organizing nanoparticles are highlighted. The large number of spectrophotometric and luminescent probe methods are categorized by ROS sensing mechanism, signaling mode, (de)activation mechanism, if any, and spectral chromaticity. Reports describing multicomponent ROS detection or novel nanoscale probes are discussed. Measurements using ratiometric, multichannel, or time-resolved detection and nonlinear spectral transitions are reviewed. The focus on developing probe molecules for spectral detection documented over the last 20 years has continued, with sustained emphasis on luminescence detection, but with less focus on spectrophotometric measurements. Use of nanoparticles as probes, probe carriers, and compartmentalization agents in ROS detection is increasing. On the other hand, incorporation of advanced spectral methods, such as nonlinear transition and multichannel detection, is increasing slowly in ROS analysis. This indicates there is a substantial opportunity to develop ROS measurements with use of a synergistic combination of (multi)functional nanoscale systems and advanced optical detection methods to optimize the detection limit, selectivity, and response time. Graphical abstract ᅟ.

Probing Electrochemical Reactions at Individual Nanostructures: Applications in Electrocatalysis and Photoelectrochemistry

The utilization of nanostructured materials in electrochemical systems for energy conversion and catalysis has shown great promise. Fundamental studies into these systems are challenging, however, due to their inherently heterogeneous nature. Variations in particle size, shape, coupling, etc. can complicate the interpretation of experimental results. While electroanalytical and optical detection schemes have been employed to study electrochemical reactions occurring at individual nanostructures, reported approaches are severely limited by sample throughput and/or assumptions necessary for data analysis. Herein, the use of a combined electrochemical and optical approach to the study of these systems is described. Scanning electrochemical cell microscopy is employed to directly measure the rate of electrochemical reactions at individual nanostructures, while optical spectroscopy is used to probe the geometry of these nanostructures in situ. This complementary approach allows for the correlation of reliable electrochemical kinetic data with structural information and for the effects of photoexcitation on electrochemical reaction rates to be examined in a direct, quantitative manner. Initial studies applying this methodology to model electrocatalytic and photoelectrochemical systems will be presented.

Optical rotation based chirality detection of enantiomers via weak measurement in frequency domain

A transmission optical rotation detection scheme based on a weak measurement was proposed for the chirality detection of enantiomers. In this transmission weak measurement system in the frequency domain, the optical activity of the chiral liquid sample was estimated with the central wavelength shift, by modifying the preselected polarization state with the optical rotation (OR). The central wavelength shift of output spectra is sensitive to the OR angle but immune to the interference of the refractive index change caused by measuring circumstances. Two isomers of chiral amino acid acquired opposite responses with this system, and a resolution of 2.17 × 10−9 mol/ml for Proline detection could be obtained. Such a resolution is about 2 orders of magnitude higher than that of common methods, which shows a high sensitivity. This proposed weak measurement scenario suggested an approach to polarimetry and provided a way to accurately assess molecular chirality.

Sensitive singular-phase optical detection without phase measurements with Tamm plasmons

Spectrally-tailored interactions of light with material interfaces offer many exciting applications in sensing, photo-detection, and optical energy conversion. In particular, complete suppression of light reflectance at select frequencies accompanied by sharp phase variations in the reflected signal forms the basis for the development of ultra-sensitive singular-phase optical detection schemes such as Brewster and surface plasmon interferometry. However, both the Brewster effect and surface-plasmon-mediated absorption on planar interfaces are limited to one polarization of the incident light and oblique excitation angles, and may have limited bandwidth dictated by the material dielectric index and plasma frequency. To alleviate these limitations, we design narrow-band super-absorbers composed of plasmonic materials embedded into dielectric photonic nanostructures with topologically-protected interfacial Tamm plasmon states. These structures have planar geometry and do not require nanopatterning to achieve perfect absorption of both polarizations of the incident light in a wide range of incident angles, including the normal incidence. Their absorption lines are tunable across a very broad spectral range via engineering of the photon bandstructure of the dielectric photonic nanostructures to achieve reversal of the geometrical phase across the interface with the plasmonic absorber. We outline the design strategy to achieve perfect absorptance in Tamm structures with dissipative losses via conjugate impedance matching. We further demonstrate via modeling how these structures can be engineered to support sharp asymmetric amplitude resonances, which can be used to improve the sensitivity of optical sensors in the amplitude-only detection scheme that does not require use of bulky and expensive ellipsometry equipment.

Cryogenic Model of the Gravitational Antenna OGRAN

The optoacoustic gravitational-wave antenna (OGRAN) located in the underground laboratory of the Baksan Neutrino Observatory has a limited sensitivity sufficient only to detect gravitational radiation from astronomical objects at a distance of 100 kpc. In order to cover sources in the zone with a radius of up to 15 Mpc, it is proposed to economically upgrade the antenna and cool down the body of the acoustic detector to a temperature of liquid nitrogen of ~78 K [1]. In this case, the spectral density of the Brownian noise of the detector decreases owing to temperature and also owing to the subsequent increase in its acoustic Q factor by one and a half to two orders of magnitude. This paper presents the results of an experiment for testing these ideas on the cryo-OGRAN prototype while preserving the optical detection scheme used for the uncooled antenna.

A High-Sensitivity, Integrated Absorbance and Fluorescence Detection Scheme for Probing Picoliter-Volume Droplets in Segmented Flows.

Droplet-based microfluidic systems that incorporate flowing streams of pL-volume droplets surrounded by a continuous and immiscible carrier phase have attracted significant recent attention due to their utility in complex chemical and biological experimentation. Analysis of pL droplets, generated at kHz frequencies and moving at high linear velocities, is almost exclusively achieved using fluorescence-based detection schemes. To extend the applicability of such optical detection schemes, we herein report the development of a simple and cost-effective optofluidic platform, integrating liquid-core PDMS waveguides, that allows the accurate measurement of absorbance within individual pL-volume droplets moving within segmented flows. Using such an approach, differential measurements of "sample "and "reference" droplets can be acquired at 1 kHz and yield detection limits of 400 nM for fluorescein in water. Significantly, the presented technique enables simultaneous fluorescence and absorbance interrogation of rapidly moving droplets in a fully automated manner. Proof of principle is demonstrated through the titration and monitoring of pH gradients in real time.