Walter Toman (1961) has presented interesting issues concerning family constellations and male-female relationships. One contention is that a person who has a sibling of the opposite sex is more likely to accept friends of the opposite sex than a person who has no opposite sex sibling. The present study, which is part of an ongoing project on male-female relationships, concerned how comfortable males and females (who are not romantically involved) feel with friends of the opposite sex and the effects of the presence or absence of opposite sex siblings on these relationships. A questionnaire was distributed to 80 undergraduates at Rider College, 21 females with brothers, 17 females without brothers, 23 males with sisters, and 19 males without sisters. They were asked to think about friends of the opposite sex (no romantic connotation) who were not relatives and how comfortable they would feel in certain activities with them. The activities were: going to dinner with, talking wich, shopping with, borrowing money from, going to a movie with, joking with, working with, asking a favor from, confiding in, discussing issues with, and going through a crisis with. The subjects responded on 7-point scales, ranging from very uncomfortable ( 1 ) to very, comfortable ( 7 ) . Half of the questionnaires listed the activities in the above order, and the other half listed them in reverse order. Subjects were randomly assigned to one version or the other. The 11 questionnaire items were combined into an over-all social interactions scale by calculating, for each subject, the mean rating of comfortableness across all 11 items. Means were subjected to a 2 x 2 analysis of variance-sex of subject and presence or absence of siblings of the opposite sex. A significant main effea for sex of subject emerged (&,;a = 5.26, p < .05), indicating that females rated themselves as more comfortable with male friends than did males with female friends. However, a significant interaction (F1.m = 7.04, p < .01) shows that, in line with Toman's hypothesis, especially females with brothers feel comfortable with male friends ( M = 6.06, SD = .53) rather than females without brothers ( M = 5.42, SD = .57). Contradicting Toman's hypothesis, males with sisters are actually slightly less comfortable with female friends (M = 5.21, SD = .94) than are males without sisters ( M = 5.48, SD = 3 9 ) . To assure that this interaction was not due merely to the influence of a few of the 11 items, means for each item were checked. The same pattern emerged for 9 of the 11 items. . In the future, variables, such as differences in ages of siblings and ordinal position of siblings, must also be considered, as well as diverse situations.