Current political and social developments have brought the topics of violence,in this context attributable to terrorism and sabotage, and since February 2022 awareness of war in particular has again greatly increased. This article aims to present the contextualized dealing with penetrating injuries in terms of initial in-hospital treatment. The question remains to be answered as to what extent penetrating injuries require special attention and to what extent the treatment priorities, options and strategies as well as surgical treatment require adaptation of the usual approach in routine clinical practice in Germany. The experience of the authors in this field from military operations in Afghanistan, Iraq, the Republic of Mali, Kosovo and Georgia as well as the core content of the Terror and Disaster Surgical Care (TDSC®) course on this topic, have been contextualized and incorporated. In addition, aspects of acomprehensive systematic literature review and current data from anational evaluation on the topic of preparing hospitals in Germany for such scenarios are taken into account. The clinical systems need to be well-prepared for such casualties, especially if they require treatment in large numbers. This is precisely so because the majority of patients are in arelevantly threatening situation (usually in the sense of ahemorrhage), treatment must be very urgently provided and in such scenarios alack of resources must always be overcome, at least temporarily, especially for example for blood transfusions.