Operations For Mitral Valve Disease Research Articles

КОРРЕКЦИЯ ЖЕЛЕЗА ПРИ БЕСКРОВНЫХ ОПЕРАЦИЯХ У БОЛЬНЫХ С МИТРАЛЬНЫМИ ПОРОКАМИ СЕРДЦА

Objective. To study the effectiveness of the preoperative combined correction, using hydroxide of iron (III) and stimulation of hematopoiesis with erythropoietin on the postoperative anemia in patients, undergoning bloodless surgery (mitral valvere placement) in conditions of artificialblood circulation. Methods. A single-center prospective non-randomized and retrospective study involving patients (n=80) undergoning the operation for mitral valve disease was carried out. There were 54 men (67.5%) and 26 women (32.5%) with an average age of 52.8±4.9 years (M±σ). The patients were divided into three groups. Group A consisted of patients with normal serum iron levels undergoning of the application of blood component preparations. Group B included patients with normal serum iron levels who were undergoning bloodless surgery. In group C the patients with initially low levels of iron in the blood serum, preoperative correction of the saturating dose iron hydroxide and stimulation with erythropoietin were carried out, and bloodless procedure was applied while the operation. Results. The results of this study show that patients in group A require a sufficiently large volume of donor blood components during surgery. In group B, mitral valve replacement can be performed using bloodless technology without transfusion of donor blood components. Correction of a low preoperative serum iron level in group C increases its preoperative serum iron level by 7.4 times and Hb by 4.4% of the initial haemoglobin values. The level of postoperative anemia in group C (p>0.05) compared with group B (p>0.05) is 8.5% less (p>0.05). Conclusion. Correction of low preoperative iron levels and stimulation of erythropoiesis in patients with mitral heart disease after mitral valve replacement using a bloodless surgery reduces the postoperative anemia level. What this paper adds For the first time the impact of preoperative correction of anemia, using iron (III) hydroxide and stimulation of hematopoiesis, applying erythropoietin in patients undergoning the surgery for mitral valve defect using bloodless technology in conditions of artificial blood circulation (ABC) has been determined.

Hypertrophic Cardiomyopathy-One Case per Year?: A Clarion Call to Do What Is Right.

Hypertrophic cardiomyopathy (HCM) has fascinated (and scared) cardiologists for years owing, in part, to the relatively fewcasesmostphysicianswill see intheirpractice,coupledwith increased risk for sudden death, complex yet incomplete genetic understanding, and enigmatic hemodynamics. The management of symptomatic patients with HCM evolved over the past (nearly) 6 decades owing to focusedefforts tounderstandthepathophysiologyandperfect the necessary skills to delivery exemplary outcomes.1 We have learned that it is entirelypossible forpatientswithHCMtohave excellent quality of life and normal lifespans, that most patients can be treatedwith pharmacologic therapy, and that for most patients who remain symptomatic, there are procedures that can deliver excellent benefit with low risk. The article by Kim et al2 using a national discharge database samplingmethod examines observed event rates among patients undergoing surgical septal myectomy or percutaneous septal ablation. Some of the findings are not surprising: there is a clear association between procedural volume and complications and there aredifferences in baseline characteristicsbetweenpatientsundergoing the2procedures.Thereare someshocking results: themediannumberofmyectomycases or ablation cases in this database is less than or equal to 1 case per year. Seriously, only 1 case per year? Why would we subject our patients to this? There is somecritical informationmissing as an artifact of the study design: specifically, there are no effectiveness data and thus, a comparison cannot be made between the results of surgical septal myectomy vs septal ablation. More importantly, there is no description of what can be expected if the procedures were performed not just at higher volume centers, but at Centers of Excellence. The study of Kim et al2 in this issue of JAMA Cardiology does go a long way to making an excellent case for having a few highly focused centers that specialize in the care of patients with HCM. The results achievable at major HCM centers are remarkable. In expert hands, surgical myectomy has a greater than 95% efficacy, with mortality rates that are approaching 0% (ie, thousands of cases performed without an operative death), normalization of long-term survival following theprocedure, anda reduction in sudden cardiacdeath.3-5 Similarly, among those patients who respond to septal ablation, the symptomatic improvement canmirror that ofmyectomy, with a procedural mortality rate that is only about 1%.6 Given that there are recognizable differences in complication rates and controversy regarding the association between septal ablation and subsequent sudden cardiac death/ implantable cardioverter defibrillator discharge rates, the American College of Cardiology Foundation/American Heart Association guidelines, as stated in the current article, recommendsurgicalmyectomyas thepreferredstrategy formostpatientswithHCMwith drug-refractory symptoms and that ablation isa reasonablealternative inselect cases.7Theguidelines emphasize that both procedures be performed by experienced centers and recommenda shareddecision-makingprocess, inwhich the fully informed patient is able to choose the procedure based on their own needs and preferences. Looking specifically at the data in the current report,2 regardless of the procedure type, there is an approximate 4-fold increase inmortality comparing the high-volume tertile to the low-volume tertile. Notably, the best mortality rates for myectomy as reported in this article, from their high-volume tertile, arestillnearly 10-foldhigher thanwhat is seenatHCMcenters.8 Thatevenhigher-volumecentersappear tohaveamortality rate that is 10 timesgreater thanwhat isobservedat centerswith focusedexpertise inHCMisanimportantobservationthat isworth seriousdiscussion. Indeed, thismayunderestimate themagnitude of the differences. Based on the data presented, the lowvolumecenterswould expect aprocedure-relateddeath for every 6 attempts, while the highest tertile reported here would expect a death for every 26 attempts. Yet,weknow frompreviouslypublisheddatathatHCMcenterscango1500ormorecases withoutaprocedure-relateddeath.8Sixvs26 is incremental improvement; 26 vs 1500 is improvement measured in magnitudes of order. There should be no debate. For years, the cardiology community has recommended andaccepted that adultswith congenital heart disease should receive their care from regional specialized centers for adults with congenital heart disease.9 Recently, given thewide variability in outcomes following operations for mitral valve disease, a disease and set of procedures that are far more prevalent than HCM, there has been a thoughtful call for these procedures to be restricted to those centers that can demonstrate excellence in benefit and safety.10 Hypertrophic cardiomyopathyhas a complexity andprevalence thatmore closely mimics that of adults with congenital heart disease, but HCM also has important abnormalities of mitral valve function. It is in the best interest of the patients then that they be informed they can expect to have a procedure with a vanishingmortality rateand95%chanceof significant,durable symptomatic benefit. No patient should have a complex procedure done where the volume is 1 per year. The data in this current report,2 coupledwith thewell-establisheddata fromHCMCenters of Excellence, make a clear case that for HCM, not every hospital or operator should be performing these procedures. The low-volume safety data are unacceptable. The middle volume data are not good enough. Even the highest-volume Editor's Note page 334

Minimally invasive mitral valve repair suggests earlier operations for mitral valve disease

Objective We began minimally invasive mitral valve surgery in August, 1996, to reduce hospital costs, to improve patient recovery, cosmetic appearance, and to decrease trauma, yet maintain the same quality of surgery. To validate this approach we reviewed our entire experience through May 2002. Methods From August 1996 to May 2002, we performed 413 minimally invasive mitral valve operations including 51 mitral valve replacements and 362 mitral valve repairs. Excluding 4 robotically assisted repairs, we evaluated 358 patients, using the mitral valve repairs as the basis for this retrospective survey. These operations were performed through a 6- to 8-cm minimally invasive incision, beginning with parasternal and, most recently, lower ministernotomy (181 patients). The mitral valve reparative techniques include repair of 94 prolapsed anterior leaflets, posterior leaflet resection, leaflet advancement, commissuroplasty, Polytetrafluoroethylene (PTFE; Gore-Tex, W. L. Gore & Associates, Inc, Flagstaff, Ariz) chordal placement, and ring annuloplasty. Cannulation sites varied but primarily utilized a miniaturized system of 24F catheters in both the inferior and superior venae cavae with assisted venous suction. The Cosgrove ring was used in 95% of the patients undergoing this procedure. Results The operative mortality was 0/358. Perioperative morbidity included a 26% incidence of new atrial fibrillation, 2% incidence of pacemaker implantation, 0.5% incidence of deep sternal wound infection, and 1.9% incidence of stroke after an operation. There were 10 arterial and 3 venous complications. The mean length of stay was 6 days and 208 patients stayed ≤5 days. Only 25% of the patients underwent homologous blood transfusion. The mean follow-up was 36 months with 1.4% lost to follow-up. There were 12 late deaths and a survival at 5 years of 95%. There were 21 valves requiring reoperation for structural valve failure of 5.8%. The probability of freedom from reoperation at 5 years was 92%. Conclusion This study documents the safety of minimally invasive mitral valve repair surgery in 358 patients. It also documents a low incidence of homologous blood use, requirement for post–hospital rehabilitation, and general morbidity.

Pulmonary Varices Associated with Mitral Valve Disease: A Case Report and Survey of the Literature

A case of pulmonary varices in a 24-year-old man with mitral regurgitation is reported. A brief summary of the literature on pulmonary varices associated with mitral valve disease is presented, with special reference to its etiology and surgical treatment. It is strongly suggested that production of varicosities of the pulmonary vein requires not only increased pulmonary venous pressure but also other local factors. If the patient has symptoms due to mitral regurgitation, operation for mitral valve disease is indicated. Direct operative intervention for the varices should not be performed.