Scrubber nozzles are key pieces of equipment used to remove aerosols in a wet-type filtered containment venting system (FCVS). This study deals with the aerosol scrubbing efficiency of a scrubber nozzle operating in self-priming mode. The scrubber nozzle that has been developed in this work consists of a reducer, a throat, a diffuser, a liquid suction slit, and an end cap with a rectangular section area. The aim of this study was to characterize scrubbing efficiency under various thermal hydraulic and aerosol conditions including nozzle inlet pressure (250–600 kPa(g)), nozzle inlet temperature (102–164 °C), nozzle inlet flow rate (air: 42–132 m3/h, steam: 112–269 m3/h), submergence from the nozzle exit (0.7–2.7 m), aerosol size (0.5, 0.7, 3 µm), nozzle inlet aerosol concentration (0.1–3 g/m3), and steam mass fraction in the main carrier gas (0–1). Aerosol scrubbing efficiency was measured based on the inlet and outlet aerosol concentrations of the scrubbing vessel with isokinetic sampling systems including a glass microfiber filter. Experimental results show that the scrubbing efficiency increased with increasing aerosol size, steam mass fraction, nozzle submergence, and inlet aerosol concentration. We also showed that the scrubbing efficiency increased with an increase in inlet pressure at low scrubber nozzle submergence. However, at higher scrubber nozzle submergence, the nozzle inlet pressure did not significantly influence the scrubbing efficiency. The aerosol scrubbing efficiency with the developed self-priming scrubber nozzle submerged in the pool was over 97% for various thermal–hydraulic conditions. Thus, the experimental results can be used to design a wet scrubber system considering upstream conditions such as operation of the FCVS.