Background:Leptospirosis is the most common zoonotic disease in Tuzla Canton. Objective: Determine the influence of environmental and precipitation factors on the incidence of leptospirosis.Methods:A retrospective study included 80 patients with leptospirosis. Data on precipitation were obtained from the online database of Federal Hydrometeorological Institute of BiH. OpenStreetMap (OSM) was used for spatial analysis; patients were geolocated and put on a map. Statistical data processing included basic tests of descriptive statistics.Results:In the period between 01.01.2014 and 31.12.2014, 80 patients with leptospirosis confirmed by clinical and serological testing were hospitalized in the Clinic for Infectious Diseases of the University Clinical Center Tuzla. Gender wise, out of 80 patients, 54 were male (67.5% of the total), and 26 were female (32.5%). More patients lived in the countryside: 64/80 (or 89%). The largest number of patients was engaged in agriculture and animal husbandry: 48/80 (or 60%), mostly cows 32/80 (40%), chickens 12/80 (15%), sheep 4/80 (5%) and pigs 3/80 (3.8%). Of the total number of patients, 50 (or 62.5%) had contact with domestic animals: dogs 10/80 (or 12.5%) and cats 5/80 (or 6.3%). Half of 53/80 (66.3%) patients had contact with flooded areas in the study period. The increase in leptospirosis diagnosed patients in the City of Srebrenik was statistically significant for 2014 (p<0.01).Conclusion:Leptospirosis in one of the neglected infectious diseases in our area, but the proven increase in the number of infected people after heavy rainfall obliges us to control the risks associated with this disease.