AbstractProper design and accurate mechanical assessment of composite C‐beam after opening are of great importance in structure engineering. This paper aims to experimentally and analytically investigate the postbuckling response of large‐size C‐beam with web opening under bending‐shear coupling load. New specimen with four different open shapes were designed and tested. Strain gauges and displacement measurements were applied to monitor its buckling behavior, strain field distribution and critical failure load. Four specimens with various openings were loaded until catastrophic failure occurred. Additionally, an analytical model was introduced to predict the residual strength of circular opening. The results indicate that while the presence of an opening significantly decreases the load carrying capacity, it has minimal effect on the bending stiffness. Compared with intact specimen, the initial delamination, buckling and ultimate strength of the circular opening decreases less than those of the rectangular opening. By altering the position of the rectangular opening, improvements can be made in terms of initial delamination resistance and buckling load; however, ultimate strength remains largely unaffected. Reinforcing the edge of an opening further reduces resistance to initial delamination but other two indicators are improved. Overall, from buckling to failure stages, post‐buckling bearing capacity after opening decreases by 40%. Moreover, the shear failure mode is observed during catastrophic failures. And the analysis method employed is relatively conservative.Highlights Ten large size composite C beams are conducted under coupling loads. Deformation, strain distribution and failure mode are presented. Influence of openings on postbuckling behavior of beam is analyzed. An analysis method is employed to predict the residual strength of beam. It could provide valuable insights for assisting in designing beam openings.