The article analyzes the sanitary and parasitological state of water bodies in the Astrakhan region in 20152019. A total of 16683 laboratory studies of water samples were conducted during the analyzed period. The number of samples taken from various environmental objects was 15253 (91,4%), of which 2595 (17%) were water samples taken from various water bodies. Of the last 82 (3,2%), samples did not meet sanitary standards. Centralized water supply was tested for parasitic contamination in 666 (25,7%) samples, swimming pool water in 947 (36,5%) samples, open water (river water) in 696 (26,8%) and wastewater in 286 (11%) samples. Of the 635 (24,5%) water samples collected in 2015, 14 (2,2%) did not meet hygiene standards. Of the 671 (25,9%) samples taken in 2016, 32 (4,8%) samples showed positive findings. Percentage of water samples collected and examined in 2017 it accounted for 463 (17,8%) of all water samples studied during the analyzed period, of which 14 (3%) did not meet sanitary standards. The share of water samples selected and tested for parasitic indicators in 2018 was 518 (22,4%), of which 18 (3,5%) samples did not meet the hygiene standards. In 2019, compared to previous years, the number of water samples taken for parasitic indicators decreased several times and amounted to 308 (11,9%), of which positive findings were noted in 4 (1,3%) samples. The absence of positive findings in water samples taken from Central water supply facilities indicates high-quality filtration and prevention of these facilities. The presence of cysts of pathogenic intestinal protozoa, as well as eggs and larvae of helminths in water samples taken from swimming pools and open reservoirs indicates fecal contamination of these objects. The presence of positive findings in wastewater samples indicates that sewage treatment plants do not provide reliable deworming and disinfection of wastewater.