Open Position Research Articles

Myosin binding protein-C: Everything, everywhere, all at once.

Myosin binding protein-C (MyBP-C) is an enigmatic protein of muscle sarcomeres that plays both structural and regulatory roles that are critical to muscle function. MyBP-C was first identified through its tight association with myosin, the force generator of muscle contraction, but it was soon recognized that MyBP-C also binds to actin on thin filaments. MyBP-C interactions with both filament systems are now known to affect contraction and relaxation through multiple complex pathways. For instance, MyBP-C inhibits thick filaments by stabilizing a slowly cycling, quiescent state of myosin (the myosin super-relaxed state, SRX). However, MyBP-C exerts opposite effects, prolonging thin filament activation and delaying relaxation, by binding to the thin filament and shifting tropomyosin to its open position. Furthermore, by simultaneously binding to both thick and thin filaments that move relative to one another, MyBP-C may act as a drag force that slows shortening velocity while also being perfectly positioned to act as mechano-sensor that efficiently relays information from one filament system to another. Here we will present structural and functional data in an integrative model describing how MyBP-C may dynamically alternate between its binding partners in a way that accounts for the ability of MyBP-C to seemingly be everything, everywhere, all at once. This work was supported by R01 HL080367 and HL140925.

Applicability of ISO 16283-3 for field measurement of sound insulation of partially open windows

Façade sound insulation regulations are typically focused on closed windows. However, many people prefer open windows for ventilation purposes, or simply because of the psychological effect of having an open window. As such it is important to be able to correctly quantify the sound insulation, also with open windows. The international standard ISO 16283-3 describes a field method for test of façade sound insulation of facades or façade elements, e.g. a window, which is further explained in the scope: "The element methods aim to estimate the sound reduction index of a façade element, for example, a window. The most accurate element method uses a loudspeaker as an artificial sound source. Other less accurate element methods use available traffic noise". However, the standard is probably primarily meant for closed windows, and not for open windows. The applicability of ISO 16283-3 for open windows is therefore under investigation for such conditions which are included in an additional Danish environmental noise guideline. Generally, it can be concluded that the traffic noise method is applicable, but care should be taken by using the loudspeaker method for partially open windows, since the results depend highly on the window opening position compared to the loudspeaker position.

Effect of Position of Opening in RC Beams Subjected to Flexure and Shear

Effect of Position of Opening in RC Beams Subjected to Flexure and Shear

Numerical Investigation of the Effects of Opening on the Strength of Masonry Wall

Masonry is used as a construction material since old age. It is a cheaper construction material compared to R.C.C. and also requires comparatively less construction skills. During an earthquake, the masonry wall constructed following the codal provisions shows preliminary behaviour in the in-plane direction of wall and it has lesser deformation in the out-of-plane direction of the wall. Although, the strength and stiffness of the Un-Reinforced Masonry (URM) walls were reduce due to sizes and positions of openings, the relationship between the seismic capacity of the walls and the position and size of opening in walls are not clear. Researchers in the past mostly explored the in-plane behaviour of solid masonry wall without opening. Considering the openings in these walls can significantly affect the strength of the masonry wall. Hence, in the present study, an attempt is made to understand the effect of varying opening sizes (4 different combinations of door and/or window openings) in unreinforced masonry wall using finite element software CATIA. From this software, URM walls were modeled and load based quasi-static analysis were done in in-plane direction. The collapse mechanisms of the masonry walls and crack patterns are studied from the analysis and a key output from this work is the characterization of the relationships between the sizes and positions of openings and the in-plane performance of masonry walls.

Sistem Informasi Problem Report Technical Support Pada PT. Bank Pembangunan Daerah Sumatera Selatan Dan Bangka Belitung Berbasis Website

PT Bank Sumsel Babel is one of the most developed regional banks in the archipelago. Bank Sumsel Babel also provides a variety of investment products, such as Depati, Demang, Telepathy, Pesirah Savings (Local Potential Activator), money transfers with Western Union, Debit Cards, export-import transactions, and ATM services. This research aims to help PT. Bank Sumsel Babel in dealing with technical support report problems. The current problem is that technical support reports independently and manually, causing delays and scattered reports. This reporting is the most important thing because the data is used for internal and external audit purposes and seeing the team's performance in solving the many problems that come in are all summarized in a monthly and annual report. Website problem report technical support is the best solution so that there are no delays in reporting and logs of solving problems that have been resolved can also be used by personal teams in solving new problems so that they can save time solving problems and a list of problem positions in open positions can be monitored by managers, administrators and the leader of the file section reports needed in audit requirements can be provided quickly.Keywords: Problem Report, Website, PT Bank Sumsel Babel

The Last Common Ancestor

The present research examined how men and women with long and short term mating preferences perceive static male nonverbal behavior. Participants saw images of interacting men depicting different degrees of: space maximization, reciprocated/non-reciprocated intrasexual touch, gesticulation patterns of gesture/no gesture and palm up/neutral gestures, head cant (tilt), automanipulations, and open/closed limb positioning. They had to choose which of the 2 men was most attractive, and more flirtatious. We hypothesized that men in each dyad who displayed more: space maximization, non-reciprocated intrasexual touch, palm up gesturing, head cants (tilts), auto-manipulations, and open limb positioning would be rated as most attractive and more flirtatious. The results were consistent with the hypothesis. Specifically, men: exhibiting: palm up gesturing, open limb positioning, touch initiation, being a non-reciprocated touch recipient, auto manipulations in the hair area and neutral head positioning were rated as most attractive. Also, men exhibiting: palm up gesturing, open limb positioning, touch initiation, space maximization, automanipulations in the hair area, and a head cant(tilt) were rated as more flirtatious. Findings are discussed in terms of male self-presentational motives, and prior research.

Triangle Tip-Jet Knife used as "probe mode" can reduce the risk of mucosal damage during incision and tunneling phase of peroral endoscopic myotomy (POEM) procedures.

Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic technique for the treatment of achalasia and its use has been widely spread in recent years. The Triangle Tip-Jet (TTJ) (Olympus Triangle TipKnife-J, KD645L) has become very popular in this field and currently one of the most used knives for POEM procedures. It has the capability of knife dissection along with submucosal injection and its triangle tip shape is especially useful for pulling tissue during the myotomy phase. However, its length may be too long in situations such as tight esophagogastric junction (EGJ), narrow submucosa due to fibrosis, trimming after mucosal incision and/or less experienced endoscopists3 in which preserving the integrity of the mucosa is vitally important. Distal attachment conical caps like ST Hood (DH28GR,29CR; Fujifilm, Tokyo, Japan) are commonly used for POEM, resting the distal end of the TTJ on the cap, with only the triangular tip protruding. By using straight caps, you can get a wider view and greater maneuverability, however is more difficult to calculate the distance between the triangle tip and the distal attachment end due to its straight shape. The T-shape of the distal TTJ tip was designed for its use in an open position. In this way, while using straight caps and/or less experiences endoscopists during challenging procedures (tight EGJ, submucosal fibrosis) can make them feel unsafe during incision and/or tunneling phase. Herein, we suggest the use of the TTJ knife in "probe mode"4 to reduce the distal knife length from 4.5 mm to 0.3 mm, thus allowing a greater control of the knife tip. In addition, the TTJ probe mode can be safely used with both contact and non-contact currents, which are becoming increasingly popular in recent years.

Forensic Engineering Analysis of an Apartment Freezing Sequence Using Heat Flow Equations

Four students had staggered departures from their electrically heated third-floor shared residence apart-ment to travel home for the winter holiday break. Two pipe bursts and two frozen toilets were discovered a week after the last resident had left. The property management group gathered scene evidence and analyzed the cause of the water escape. The investigation revealed that some electric heaters had been turned off, and some bedroom and living room windows were open. A forensic engineering analysis was conducted to qualita-tively determine the effects of heater disengagement and open window positions on the apartment temperature drop and to estimate the likely start date of sub-zero Celsius conditions. Heat flow and balance equations for different sets of factors were used to quantitatively assess the instantaneous heat flow trends as the basis for understanding whether certain students carried more burden of liability. The analysis revealed that the open windows were the dominant factor for the freeze-up condition development that led to the bursts.

Oscillating Back Pressure Regulator (OBPR) for High-Pressure Core Flooding

The challenge in the core analysis industry is the availability of a versatile back pressure regulator (BPR) that can operate efficiently at ultra-low or no-flow conditions at very high pressure. The existing models of back pressure regulators are limited to a specific range of operating conditions, automation, and robust core flooding environment. In this work, we developed an initial stage prototype of an Oscillating BPR (OBPR), emphasizing detailed instrumentation and implemented automation. The critical component in an OBPR is the valve that needs to operate within defined close and open position based on the feedback received from an encoder rather than the oscillation created by the flow system or by using a square wave oscillator. The paper investigates the static and dynamic characteristics of the newly designed OBPR instrument. The paper discusses the graphical programming LabVIEW software used to create the feedback control loop using the PID controller. Initial results of the test run were done with the different core flooding systems like Water, Brine, and CO2. The study also included comparing OBPR pressure performance with the standard back pressure regulator in the market.

ИССЛЕДОВАНИЕ ЭКОЛОГИЧНОСТИ БЕНЗИНОВОГО АВТОМОБИЛЯ ПУТЕМ АНАЛИЗА СОСТАВА ОТРАБОТАВШИХ ГАЗОВ ПЕРЕД АНТИТОКСИЧНОЙ СИСТЕМОЙ

A test diagnostic method is proposed, based on monitoring the toxicity parameters of exhaust gases in the exhaust manifolds of individual cylinders up to the catalytic converter with a multi-component gas analyzer. The relationships between the parameters CO2 and CH are analysed both individually and jointly when simulating changes in the technical condition of the spark plugs of the ignition system and the resistance of the catalytic converter in the exhaust system. Experiments are carried out at two throttle opening positions: 20 and 40 %. A joint analysis of the dependences of CO2 and CH shows a shift of the point of their intersection to the zone of longer or shorter injection duration, depending on the malfunction. As the exhaust resistance increases, the range of changes in CO2 and CH decreases significantly; the same is observed when the spark plug gap decreases. The presented method is recommended for use by auto service and machine-building enterprises, which will allow them to carry out highly effective monitoring of the technical condition of engine systems.

What Happened to the K–12 Education Labor Market During COVID? The Acute Need for Better Data Systems

Abstract The COVID-19 pandemic upended the U.S. education system in ways that dramatically affected the jobs of K–12 employees. However, there remains considerable uncertainty about the nature and degree of staffing challenges during the pandemic. We draw on data from the Bureau of Labor Statistics (BLS) and State Education Agencies (SEA) to describe patterns in K–12 education employment and to highlight the limitations of available data. Data from the BLS suggest overall employment in the K–12 labor market declined by 9 percent at the onset of the pandemic and remained well below pre-pandemic levels more than two years later. SEA data suggest that teachers did not leave the profession en masse as many predicted, with turnover decreasing in the summer of 2020 and then increasing modestly in 2021 back to pre-pandemic levels. We explore possible explanations for these patterns including weak hiring through the summer of 2020 and high attrition among K–12 instructional support and noninstructional staff. State vacancy data also suggest that schools faced substantial challenges filling open positions during the 2021–22 academic year. Our analyses illustrate the imperative to build nationally representative, detailed, and timely data systems on the K–12 education labor market to better inform policy.

Exploring current challenges in the technologist workforce of clinical genomics laboratories

PurposeWorkforce shortages are observed in many sectors of the economy, including clinical genomics laboratories. Although medical technologists are essential for the primary functions of laboratory operations and many institutions in the United States have reported acute staff shortages, we are unaware of any recent studies that provide concrete data detailing workforce needs. In this report, we summarize the results of a technologist-based survey sent to clinical laboratory directors across the United States. MethodsThe survey was designed to provide detailed and objective evidence on the current landscape of the technologist workforce in clinical cytogenetics, molecular genetics, and laboratories that have combined both disciplines. Survey questions included demographics, salaries across career stages, retention trends, and hiring requirements and challenges. ResultsAnalysis of the survey data from 70 US-based submissions showed that cytogenetics laboratories had higher proportion of unfilled technologist positions, whereas molecular laboratories had more applications for each open positions. The technologist retention rate in molecular laboratories was higher than that in cytogenetics. The lack of adequately trained applicants and competitive salary offers by other laboratories were cited as top barriers for filling technologist positions. ConclusionThe results from this survey will serve as normative data in generating solutions to address acute workforce needs in the United States.

A training dataset for machine learning-based prediction of window opening position in a naturally ventilated building

Window operation is the main strategy used by building occupants to naturally ventilate buildings. However, common approaches to measure window operation for energy and comfort assessments are still technically complex or insufficient; typical window open/close sensors often provide only binary information about the opening state of a window, not the extent to which the window is open. This paper is the first outcome of a research project that seeks to use photo imagery and machine learning to predict the variable opening state of windows on a real multi-family residential passive house located in Vancouver, Canada. The employed windows are European-style in that they can be opened in tilt or turn mode. To eventually train the algorithm, a ground-truth dataset is constructed by manually changing the opening state of sixteen windows every minute over a 15-hour test period spanning three days and taking a photo of the windows at each instance, measuring the angle each time. This paper documents the first outcome of the overall project: the publication of the training dataset itself, with over 10,000+ images of a building fac¸ade taken, under variable-but-known window opening state, and under various light conditions. The paper presents the testing methodology undertaken for generation of the dataset and provides instructions for how to access the dataset. In the future, these images will be used to calibrate a machine learning model to estimate window opening/closing state of the tested building. The dataset can also be extended for semantic segmentation in support of other machine learning problems.

АНАЛІЗ БІРЖОВОЇ ТОРГІВЛІ ДЕРИВАТИВАМИ НА МІЖНАРОДНИХ ТОВАРНИХ І ФОНДОВИХ БІРЖАХ

The article highlights the organizational aspects of the functioning of international commodity and stock exchanges in the conditions of globalization and instability. It was noted that international exchange trading is an organized form of wholesale trade in commodity and financial base assets. International exchange trade currently performs important functions for the formation of global economic stability. International exchange trading on commodity and stock exchanges is an important place for the accumulation and redistribution of investment resources at the global level. Features of international exchange trading in derivative contracts are highlighted. The current state of international exchange trading on commodity exchanges and stock exchanges by geographic regions is analyzed. Growth rates in recent years on the international stock market have been noted. An assessment of international exchange trade in various types of commodity and financial assets is presented. The main modern trends of international exchange trade in derivative contracts on commodity and stock exchanges are established. In 2022, the continuation of the following trends is observed: continuation of the annual growth of indicators of international stock trade; resumption of activity of financial institutions after the pandemic and in the conditions of war in Ukraine; providing entrepreneurs with favorable terms of lending and financial support; satisfaction of customers' needs in goods and services; increasing the pace of international exchange trading in financial derivative contracts; recording new record indicators of trade volumes and the number of open positions on international stock exchanges. The main problems facing global stock markets today are: wars and military conflicts that continue and escalate in various parts of the world, primarily in Ukraine and Israel; establishment of new logistic ways of delivery of commodity assets, which are disrupted due to the war in Ukraine; struggle with the consequences of price fluctuations on international exchange platforms due to uncertainty and new geopolitical risks; reduction of inflationary pressure due to the liberal policy of central banks.

Оценка влияния маржинальных требований на ликвидность российского рынка фьючерсов

The implementation of a margin system in derivatives markets has a positive effect on market liquidity and market pricing efficiency. At the same time, portfolio diversification and hedging are not fully taken into account when assessing margin requirements. Therefore, in order to comply with regulatory requirements, the exchange sets excessive margins. IAs Charoula Daskalaki and George Skiadopoulos have shown, overestimation of margin requirements reduces the positive effect of the existence of a margin system. However, quantification of this observation has not been presented in studies before. This paper quantifies the dependence of market liquidity on the level of margin. The study is conducted on data from futures contracts for 19 underlying assets traded on the Moscow Exchange between 2014 and 2021, using an autoregressive moving average model with exogenous factors (ARMAX). The stability of the obtained results is determined by comparing different model specifications with different sliding window sizes. The analysis not only confirmed the fact that margin requirements, which protect the exchange's capital, reduce the positive effect of implementing a margin system but also allowed to evaluate it quantitatively: a 1% increase in margin requirements in relative terms reduces trading volume from 2.5 to 7% and the volume of open positions from 0.2 to 0.9%, depending on the type of position and trader. The impact on trading volume is on average stable over time, and there are local trends and tipping points for the volume of open positions.

Comparative Analysis of Open Position and Hedging Techniques in The Import Value Management of PT Pertamina (Persero)

Fluctuations in currency exchange rates result in the value of the company's debt of import payment to be uncertain because any time may be changing. Companies can do hedge techniques to protect the value of the import debt or leave it in a state without the hedge. The purpose of this research is to know the value of the company's debt of import when using forward contract hedge, money market hedge, and open position and choose the most efficient method. This research uses import transaction data of PT Pertamina (Persero). The analysis technique used is the Wilcoxon Signed Ranks Test and calculation with Microsoft Excel. From this research, it is found that there is no difference in the average value of the company's import debt when using forward contract hedging technique with an open position. But there is a difference when using money market hedge technique with the open position. The result of the research is the value of import debt is more efficient when the company uses open position or without the hedge.

GAP Ratio, Posisi Devisa Neto, Biaya Operasional Pendapatan Operasional dan Profitabilitas pada Perbankan di Indonesia

This research intends to examine the factors that influence the profitability of the banking industry since, as a sector that influences economic circumstances, the banking industry has witnessed fluctuations in profitability over the previous decade. This form of study employs quantitative secondary data sources. The population of this research consisted of all state-owned banks from 2010 to 2021. Multiple linear regression test and also hypothesis testing are employed in this study. Using descriptive quantitative statistics, the technique of analysis explains the relationship between the dependent and independent variables. The study's findings give empirical proof that gap ratio and BOPO have a negative impact on ROA. Meanwhile, PDN has no impact on ROA. This study also demonstrates the validity of the theory of asset-liability management (ALMA); maximizing earnings via risk-managing the structure of the business's financial situation and the anticipated income theory; increasing bank liquidity and optimize bank earnings by offering efficient long-term lending.
 Keywords: Gap Ratio; Net Open Position (NOP); Operating Cost of Operating Income (BOPO); Profitability (ROA)

Torsional Behavior of RC Beams with Transverse Openings Strengthened by Near Surface Mounted-Steel Wire Rope Subjected to Repeated Loading

The presence of the openings negatively effects on the strength of the beams where they act as a weak point because of the sudden change in the cross-section of the beam, so it becomes necessary to make strengthening for the beams to resist the effect of the openings and improve the strength of the beams, especially if the beams are subjected to repeated loads because of its effect on the strength at the failure. This paper studies the effect of the openings on the beams subjected to repeated loading and determine the extent of the increase in the strength of the beams when strengthened by the NSM technique. The experimental program included casting and testing fifteen RC beams, six of them considered as a control beams (three with strengthening and three without strengthening), and nine of them having circular transverse openings in different locations and strengthened by the NSM technique. Every type of beams is tested under three different types of loads (monotonic, constant repeated load, and incremental repeated load). All of the beams have the same dimensions and same reinforcement. The results show that all the beams with transverse openings are affected by repeated loads where the ultimate torque decreases and the twist angle increases. The existence of openings has a noted effect on reducing the ultimate torque, whereas the percentage of decrease in the ultimate torsional capacity reached 43.83% at the beam where the opening location is closest to the support (at the quarter of the clear span) and subjected to constant repeated loads, and the ultimate torque is significantly improved when the opening position is moved away from the supports. Also, the existence of strengthening reduced or eliminated the influence of openings on the ultimate torque compared with related non- strengthened beams.

Determination of the position of the openings of the facial part of the skull in relation to craniological points and bony landmarks depending on the facial index of a person of mature age

Annotation. Knowing the exact position of the openings in the facial part of the skull, through which vessels and nerves pass, is extremely important for performing operative, reconstructive and other interventions in this area. Since there is considerable variability in the position of the supraorbital (SOH), infraorbital (IOH) and submental (SMOH) holes, the purpose of our work is to determine the exact spatial position of the above-mentioned holes relative to cranial points and bony landmarks depending on the facial index of a mature person. Studies were conducted on 52 bone preparations of skulls using commonly accepted instruments and 60 CT images of mature Caucasians without pathology of the bones of the facial part of the skull. Studies on CT images were carried out using a virtual Anatomage table using the Launching Table 6.0 Application program. Statistical methods were used to analyze the obtained measurement results in our research, which was carried out with the help of the Microsoft Excel 2010 © licensed program package and with the help of the “STATISTYCA” program. To determine the interdependence of features in the general population, a correlation analysis was performed. In the course of the study, we determined the average values of the distances from the SOH, IOH and SMOH to the following craniological points: nasion (n.), nasospinale (ns) and frontomalare orbitale (fmo) depending on the facial index. Analyzing the obtained data, significant differences in the position of the above-mentioned openings to the corresponding craniological points were clearly observed depending on the type of structure of the facial part of the skull. There was an increase in the distances from the SOH and IOH to the nasion point and the frontmolar orbital point in euryprosopics, and smaller results were obtained in leptoprosopics. The average values of the distance indicators from the SOH, IOH and SMOH to the nasolabial point were significantly larger in leptoprosopics, in contrast to euryprosopics. When determining the size of the supraorbital margin and the distance from the SOH to the supraorbital margin, euryprosopics prevailed. The obtained results of measuring the distance from the IOH to the edge of the upper jaw and from the SMOH to the upper and lower edges of the lower jaw indicate an increase in these distances in long-faced (leptoprosopic) in contrast to wide-faced (euryprosopic). The results of the study indicate the dependence of the position of the openings of the facial part of the skull on the facial index, which will make it easier in clinical practice to determine the position of the nerves and vessels coming out of these openings.

Implementor Involvement In Increasing Children’s Immunity During A Pandemic In Muara Dua Sub-District

Vaccination programme for children aged 6 to 11 in Muara Dua District, Lhokseumawe City: readiness of essential stakeholders and parents to increase children's immune protection. Decree of the Republic of Indonesian Minister of Health (KMK) Number HK.01.07./MENKES/6688/2021. The Covid-19 vaccine is only given in school settings during the pandemic and is intended to prevent children between the ages of 6 to 11 from being exposed to the virus and provide them with safety during face-to-face learning (PTM). Lhokseumawe City executes the Covid-19 detonation in accordance with the directives of the federal government. Many youngsters between the ages of 6 and 11 in Lhokseumawe City have received vaccines. The cooperation and support of the appropriate parties is crucial for the successful implementation of this strategy. Qualitative application of research methods, informants were determined purposively by considering the criteria. Using observation, interviews, and documentation to obtain data. Implementation of a child immunization program actually requires the participation and support and readiness of various parties. Based on research findings, the readiness of the implementers has been successful, as evidenced by the support of parents in bringing their children to open service positions and the mental strength of the implementers. Safe vaccination services are provided for children.