Shenhua BaoRi XiLe open-pit coal mine slope is located in the seismic belt of hulunbuir prairie in Inner Mongolia, which belongs to the high frequency and intensity earthquake zone, with rainfall concentrated, poor geological distribution, under the influence of complex environmental factors, extremely easy to cause landslide. This paper uses grey model and support vector machine (SVM) to establish slope model, and carries out stress and strain characteristics under the condition of natural, rainfall, earthquake and calculation and analysis of stability. Through the experiment, it analyzes the stability coefficient of downhill under rainfall condition, and obtains the different strength reduction of safety factor list. At the same time, give full consideration to the uncertainty of the earthquake, assume a variety of working conditions of the earthquake, it conducts dynamic analysis of the slope in detail, and gets the dynamic characteristics curves of the monitoring points. Results show that, relative complex terrain conditions, climate conditions and at a high intensity earthquakes area, are the main factors to induce landslides in this region. Therefore, this paper provides a reliable basis for further study of the effects of rainfall and earthquake on slope and disaster prevention and mitigation.