A modified micromechanics failure criterion (MMF3) based multi-scale analysis strategy was proposed in this article to analyze the failure behaviors of the plain-woven fabric composites. The finite-element (FE) representative unit cell (RUC) models of different scales were first established, and the RUC based stress transformation methods were developed. The micro-scale strengths of the constituents in the unidirectional laminate were achieved based on the tested macro-scale strengths. Under the micro-scale strength invariance hypothesis, the meso-scale strengths of the fiber tows from the plain-woven fabric composites were back-calculated first and were then validated and corrected with the assistance of tested strengths of the fabric laminates. With the micro-scale RUC and the calculated meso-scale strengths of the fiber tows, the micro-scale strengths of the constituents suitable for the plain-woven fabric composites were determined. The multi-scale analysis procedure for the plain-woven fabric composites was then established in providing a more direct failure observation at the constituent level. Open-hole compression specimens were tested according to the ASTM standard D6484, and the failure of the open-hole fabric laminate was simulated with the proposed multi-scale strategy. The numerical predictions were in good agreement with the experimental results, and the feasibility of the multi-scale strategy was validated.