Open-graded friction course (OGFC) is a thin asphalt mixture surface layer. It is gap-graded with a high percentage of coarse aggregates that are nearly uniform in size, resulting in a high percentage of interconnected air voids and asphalt binder, which provides improved skid resistance, visibility, and decreased pavement–tire noise. However, construction personnel at the Louisiana Department of Transportation and Development reported that conventional OGFC mixtures have durability issues and shorter service life, compared with thin asphalt mixture lifts. Hence, effects of different asphalt binder types on the performance of OGFC mixtures were evaluated. Five types of asphalt binder were utilized: conventional styrene-butadiene-styrene (SBS) asphalt binder PG 76-22M; high SBS content asphalt binder PG 88-28; diluted epoxy asphalt (EA) binder with two different dosages (25% and 50%); and a hybrid modified asphalt binder prepared with SBS and crumb rubber modifier PG 76-22G. The optimal aggregate structures were determined based on minimum required air voids and voids in coarse aggregate. Physical and mechanical tests were conducted to assess the performance of OGFC mixtures, including draindown, permeability, loaded wheel track, and Cantabro abrasion loss. Results indicate that OGFC mixtures incorporating diluted EA binder exhibited lower draindown values than mixtures containing PG 76-22M and PG 88-28. Moreover, mixtures with PG 88-28 and 50% EA binders demonstrated improved resistance to rutting. Mixtures with 50% EA and PG 88-28 binders demonstrated improved durability, compared with mixtures with PG 76-22M for unaged and aged conditioning, as measured by Cantabro abrasion loss values.