Open Archives Research Articles

Wound-contractible hydrogel for skin regeneration, a new insight from mechanobiology

Wound-contractible hydrogel for skin regeneration, a new insight from mechanobiology

Elucidating molecular mechanisms of two-dimensional chemical reactions

Elucidating molecular mechanisms of two-dimensional chemical reactions

Locating the Italian Radioactive Waste Repository: Issues and Perplexities Arisen from Open Data-Based Analyses about the TO-10 Site (NW Italy)

Recently, Italy has started the procedure for the selection of suitable sites for hosting the National Repository for Low-Medium Activity Radioactive Wastes. Sogin spa, a public company, taking into account the criteria of the ISPRA Technical Guide no. 29, solicited by the EU Directive 2011/70/Euratom, has presented the CNAPI (National Map of the Potentially Suitable Areas) which has become operative since 5 January 2021. Sixty-seven sites were identified in Italy as potentially suitable for hosting the repository. Some criticalities immediately appeared concerning the properness of the selection. An analysis was, therefore, achieved to explore part of the rationales underlying the adopted procedure. A paradigmatic site, namely the TO-10 one (NW Italy), was chosen for the analysis, which highlighted significant anomalies affecting both the procedure rationales and its results. Since the selection process majorly relies on geographical data, attention was particularly paid on the role of official data from open archives. With reference to the most updated and detailed ones, we demonstrated that the Sogin procedure suffers from several critical points. In particular, with reference to the TO-10 site, we found that it cannot be absolutely considered to be suitable for hosting the National Deposit. In fact, it proved to match several exclusion criteria included in the ISPRA Technical Guide n. 29. These include: the potentially high “seismic risk” due to a “seismic gap” and complex tectonics associated with uplift (up to 1–1.5 mm/y); a highly vulnerable and extremely superficial groundwater table; a high permeability (10−2–10−3 m/s) of the cover sedimentary units; not proper buffer zones around local settlements. In spite of the local specificity of the analysis, results concerning procedure weaknesses are general. Consequently, we expect that they can be a stimulus for Sogin to more properly face the next steps of the selection procedure.

Methane oxidation to methanol over copper-containing zeolite

Methane oxidation to methanol over copper-containing zeolite

A comparative study of India and Australia open access repositories in open DOAR

An open access repository or open archive is a digital platform that holds research output and provides free, immediate and permanent access to research results for anyone to use, download and distribute. To facilitate open access such repositories must be interoperable according to the Open Archives Initiative Protocol for Metadata Harvesting (OAI-PMH). Search engines harvest the content of open access repositories, constructing a database of worldwide, free of charge available research. OpenDOAR is the quality-assured, global Directory of Open Access Repositories. Its repositories provide free, open access to academic outputs and resources. This paper deals with Comparative analysis of India and Australia repositories listed in OpenDOAR in terms of their growth, type, operational status, content type, software, subject coverage, language and policies regarding content, submission, and preservation. Keywords: Digital Repositories, Institutional Repositories, Open Access, OpenDOAR.

Developed DICOM standard schema with DSpace

PurposeThis paper aims to present a novel DSpace-based medical image repository system planned explicitly for storing and retrieving clinical images using digital imaging and communication in medicine (DICOM) metadata standards. DSpace institutional repository software is widely used in an academic environment for accessing and mainly storing text-related files. DICOM images are particular types of images embedded with much system-generated metadata and organised using DICOM metadata standards.Design/methodology/approachThe present paper talks about institutional repository software (DSpace) in archiving DICOM images. In the current study, the authors have tried to integrate the DICOM metadata standard with DSpace, which was compatible with Dublin Core (DC) and open archives initiative – protocol for metadata harvesting (OAI-PMH). After combining the DICOM standard with DSpace and the repository tested with a sample of 5,000 images, the retrieval results using various DICOM tags was very satisfactory. This study paves for the use of open source software (OSS) in storing and retrieving medical images.FindingsThe author has provided the DSpace software to recognised DICOM (.dcm) files in the first stage. In the second stage, a patch was developed to identify the DICOM metadata standard in Dspace, which has inbuilt DC metadata standards. Finally, in the third stage, retrieval efficiency was tested with a 5,000 .dcm image using the DICOM tag and the results were very fruitful.Research limitations/implicationsA major limitation of this study was the size of the data (5,000 DICOM images) with which the authors have tested the system. The system scalability has to be tested on various fronts like on cloud and local servers with different configurations, for which a separate study has to be done.Practical implicationsOnce this system is in place, DICOM users can stock, retrieve and access the image from the Web platform. Furthermore, this proposed repository will be the warehouse of various DICOM images with reasonable storage costs.Originality/valueIn addition to exploring the opportunities of free open source software (FOSS) implementation in medical science, this study includes issues related to the performance of an open-source repository for retrieving and preserving medical images. It created and developed Open Source DICOM Medical Image Library with DICOM metadata standard with the help of DSpace. Thus, the study will generate value for library professionals and medical professionals and FOSS vendors to understand the medical market in the context of FOSS.

Switching the O–O bond-formation mechanism by controlling water activity

Switching the O–O bond-formation mechanism by controlling water activity

Engineering reversible isomerization at the nanoscale via intermolecular interactions

Engineering reversible isomerization at the nanoscale via intermolecular interactions

The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types

The Genome Sequence Archive (GSA) is a data repository for archiving raw sequence data, which provides data storage and sharing services for worldwide scientific communities. Considering explosive data growth with diverse data types, here we present the GSA family by expanding into a set of resources for raw data archive with different purposes, namely, GSA (https://ngdc.cncb.ac.cn/gsa/), GSA for Human (GSA-Human, https://ngdc.cncb.ac.cn/gsa-human/), and Open Archive for Miscellaneous Data (OMIX, https://ngdc.cncb.ac.cn/omix/). Compared with the 2017 version, GSA has been significantly updated in data model, online functionalities, and web interfaces. GSA-Human, as a new partner of GSA, is a data repository specialized in human genetics-related data with controlled access and security. OMIX, as a critical complement to the two resources mentioned above, is an open archive for miscellaneous data. Together, all these resources form a family of resources dedicated to archiving explosive data with diverse types, accepting data submissions from all over the world, and providing free open access to all publicly available data in support of worldwide research activities.

TPC2 targeting evolution: Leveraging therapeutic opportunities for cancer

Growing evidence implicates a vital role for TPC2/Ca2+ signaling in pathophysiological processes attributed to cancer, raising questions regarding the utility of TPC2 as a cancer therapeutic target. In this issue of Cell Chemical Biology, Müller etal. (2021) develop TPC2 inhibitors, SG005 and SG-094, exhibiting anti-tumor effects with potential translational relevance.

Infection makes micro-CHIPs into macro-CHIPs.

In this issue of Cell Stem Cell, Hormaechea-Agulla etal. (2021) demonstrate that IFNγ signaling following an infection in mice provides a selective pressure that drives growth of Dnmt3a-/- hematopoietic stem cells. This clonal expansion is mediated by global methylation changes that lead to an increased self-renewing capacity.

Investigating capability of open archive multispectral and SAR datasets for Wheat crop monitoring and acreage estimation studies

Investigating capability of open archive multispectral and SAR datasets for Wheat crop monitoring and acreage estimation studies

Profiling selective binding to promoter CpG islands by a single-DNA mechanical footprinting assay

Profiling selective binding to promoter CpG islands by a single-DNA mechanical footprinting assay

Advances in strain engineering on oxide heteroepitaxy

Advances in strain engineering on oxide heteroepitaxy

Toward a mechanically stable solid electrolyte interphase

Toward a mechanically stable solid electrolyte interphase

Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions?

Astrocyte-secreted Hevin induces synapse formation by bridging the trans-synaptic organizers, neuroligins and neurexins. In this issue of Structure, Fan etal. (2021) elucidate the structural basis of Hevin's interaction with these molecules and reveal the competitive interplay between Hevin, SPARC, and MDGAs.

Alleviating halide perovskite surface defects

Alleviating halide perovskite surface defects

Information resources for the reconstruction of the collective portrait of the headquarters of the 316th rifle division in 1941

The article talks about the author’s search work for staff of the headquarters of the first body of the 316th rifle division in 1941 in the battle of Moscow. The goal: based on the open archives of Russia and Kazakhstan in 2017, to give an analysis of the personal data of staff employees of 1941. Methods: Methodology of comparative-historical research, methodology and technique of socio- logical research, comparative-historical method and analysis of statistical data, etc. Take advantage of interdisciplinary methodology, content analysis, and qualitative document analysis. Based on the study of only recently discovered data for researchers, a number of important conclu- sions that refute the opinions voiced in the twentieth and early 21st centuries were made. The headquar- ters included representatives of 6 nationalities of the country. More than a quarter of the headquarters were non-partisan people. 77.8% of commanders with higher and secondary education worked at the headquarters. 54.2% of staff employees did not have a military education, which is one of the reasons why the division was called militia. The division served as a bridgehead for the offensive operations of the Moscow battle, which drove the enemy hundreds of kilometers from the capital. The practical significance of the study is the possibility of using its results in the field of culture and history. The results of the study can be integrated into educational processes. Tips and recommendations are given to journalists and PR specialists on how to cover topics based on the search for archival materials and its analysis. Materials can be included in history, journalism and public relations textbooks of the twentieth century. Key words: 316 rifle division, Central Archive of the Ministry of Defense of Russia, Central Archive of the Republic of Kazakhstan, journalists, archive works coverage in media.

Soft-fiber-reinforced tough and fatigue resistant hydrogels

Soft-fiber-reinforced tough and fatigue resistant hydrogels

Higher-voltage asymmetric-electrolyte metal-air batteries

Higher-voltage asymmetric-electrolyte metal-air batteries