ABSTRACT The effect of various therapeutic interventions on quality of life (QoL) among breast cancer patients is vital. The purpose of this systematic review was to investigate therapies that target patients with breast cancer’s health-related QoL (HRQoL). The literature search was carried out in the Cochrane, Medline, Embase, and CINAHL databases and PubMed between January 2015 and March 2023 which included published theses and articles from a variety of national and international databases. To extract pertinent material, the text and abstract of the chosen articles were carefully reviewed and evaluated. By applying the PRISMA guidelines, the Google search engine’s search parameters were expanded to encompass open-access articles, guaranteeing a greater variety of resources for the research. Following the screening of various citations, 284 full-text articles were examined. In the end, 14 articles were included. The reviews emphasized the effectiveness of therapies meant to improve HRQoL in individuals with breast cancer. The physical, psychological, and social domains saw therapeutic effects from these therapies, which resulted in a major improvement in the HRQoL of breast cancer patients. The importance of including different therapies in the treatment of patients with breast cancer is underscored by the persistent evidence of noteworthy enhancements in HRQoL. Overall, the review supports the recommendation for incorporating counseling, psychological interventions, educational programs, and supportive therapies such as progressive muscle relaxation as essential components of comprehensive care for breast cancer patients. By addressing the multidimensional needs of patients, these interventions contribute to improved HRQoL and overall well-being throughout the breast cancer journey.
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