Online Virtual Museums (OVM) serve as vital conduits for the global propagation of cultural heritage but grapple with the challenge of user disorientation due to the absence of physical references. Leveraging the successful paradigm of game-based virtual navigation, this study investigates the potential integration of game mini-map navigation design elements into OVM to enhance spatial cognition. Through empirical investigation, a conceptual model was developed to probe the role of core mini-map design elements (interactivity, visual guidance, and information content) in augmenting spatial cognition. Results indicate that optimizing these elements significantly enhances user immersion and presence, thereby improving spatial cognition. Specifically, information content and visual guidance exerted stronger effects on immersion and presence, respectively. This research contributes a novel perspective on incorporating game design strategies into non-game virtual experiences, offering practical guidance for enhancing navigation in OVM and similar virtual environments. This bridges the gap between virtual museum navigation and game design, propelling the evolution of more dynamic, interactive, and user-centric virtual environments, thus fostering the preservation and dissemination of digital cultural heritage.