Online Trial Research Articles

PENGEMBANGAN BAHAN AJAR DARING BERBANTUAN PLATFORM EDMODO PADA MATERI PERBANDINGAN

This research aims to gain mathematics teaching materials that can be used online with the help of the Edmodo platform for grade VII junior high school students which has the criteria in learning mathematics at the classroom. The method used in this case is research and development (R&D) method with the ADDIE model which consists of five stages, namely Analysis, Design, Development, Implementation, and Evaluation. The subjects in this research were 32 students of class VII SMP Negeri 3 Kramatwatu, and involved media experts and material experts as well as mathematics teachers as validators. The data collection technique was done by giving a questionnaire. The initial analysis was carried out descriptively, while the feasibility data analysis was carried out as follows. (1) online teaching material products assisted by the Edmodo platform are compiled which will later be in the form of powerpoints and videos, (2) the feasibility of media and materials is based on the validation results of 80.5% media experts and 78.46% material experts so that they are included in the appropriate criteria, while the results teacher's assessment of 79% indicates the criteria are feasible. The revised product will be tested on students through online trials with 82.88% results, which shows very good criteria. Thus, online teaching materials assisted by the Edmodo platform on comparative materials are appropriate to be used as learning materials for mathematics.

E-Court in resolving civil cases - Foreign experiences and recommendations for Vietnam

Applying digital technology in state management activities is a trend that many countries are actively implementing. Experiences from other foreign countries show that digitizing and technologizing judicial activities is an inevitable trend to simplify administrative procedures, maximize the settlement of disputes to ensure legitimate rights of people, and to maintain social order. Vietnam is therefore not out of that trend. However, the application of information technology to the Court's activities in Vietnam has just been initially organized through a number of activities such as online filing, electronic case management..., but for the online trial, the Vietnamese law still does not have a complete legal framework. In the context of Covid-19 epidemy, the employment of E-court becomes even more necessary than ever. Because of social distancing, many activities, including court trial have been postponed. This can cause many inconveniences to the court (to comply with the law on procedural time), and to the parties (who wants to solve their legal issues as quick as possible, so that they can enjoy well their legal rights and interests). However, this model of court needs many conditions to be developed: investment of Government, qualifications of competent persons, people’s scientific and technical level… It should be noted that technological measures are just a different implementation method of the procedural provisions, but due to being as the procedural law, these implementation steps should be clearly specified in the law, so as not to be considered a violation of the proceedings. Thus, the contents of law need to be legalized such as applicable conditions, procedures on initiating a lawsuit, on giving announcement to parties... In fact and theory, all kind of civil cases can be judged online as long as the requirements of platform and demand of participating parties are met. And the civil procedure law can add regulations about the online method to some of necessary procedural steps as an additional choice to the parties. The article focuses on recommending the building of a E-Court model in Vietnam in civil proceedings, where this model can be effectively applied due to the civil nature of the case, with the research method of analysis, thesis and comparison with other foreign laws, such as Malaysia, Korea, Australia and Canada.

Educating Pharmacists on the Risks of Strong Opioids With Descriptive and Simulated Experience Risk Formats: A Randomized Controlled Trial.

Objectives. High opioid prescription rates in the United States and Europe suggest miscalibrated risk perceptions among those who prescribe, dispense, and take opioids. Findings from cognitive decision science suggest that risk perceptions and behaviors can differ depending on whether people learn about risks by experience or description. This study investigated effects of a descriptive versus an experience-based risk education format on pharmacists’ risk perceptions and counseling behavior in the long-term administration of strong opioids to patients with chronic noncancer pain. Methods. In an exploratory, randomized controlled online trial, 300 German pharmacists were randomly assigned to either a descriptive format (fact box) or a simulated experience format (interactive simulation). Primary Outcome Measures. 1) Objective risk perception, 2) subjective risk perception, and 3) intended and 4) actual counseling behavior. Results. Both risk formats significantly improved pharmacists’ objective risk perception, but pharmacists exposed to the fact box estimated the benefit-harm ratio more accurately than those exposed to the simulation. Both formats proved equally effective in adjusting pharmacists’ subjective risk perception toward a better recognition of opioids’ harms; however, pharmacists receiving the simulation showed a greater change in their actual counseling behavior and higher consistency between their intended and actual counseling than pharmacists receiving the fact box. Conclusion. The simulated experience format was less effective than the descriptive format in improving pharmacists’ objective risk perception, equally effective in motivating pharmacists to counsel patients on less risky treatment alternatives and more effective in changing the reported actual counseling behavior. Implications. These exploratory findings provide important insights into the relevance of the description-experience gap for drug safety and raise questions for future research regarding the specific mechanisms at work.

Implementation of Criminal Action Prosecution Online in Realizing Principle of Fast Prosecution, Simple & Low Cost

Indonesia is a state of law, thus everything is regulated by law, if there are people who violate the law then it is resolved through a judicial process. The Covid-19 virus has had an impact on the need for online trials. The formulation of the problem in this study is how the implementation and constraints of the implementation of the stages of prosecuting criminal cases (online) and how the ideal implementation in the application of the stage of prosecuting criminal cases (online) in order to realize the principles of fast, simple and low-cost justice in Indonesia. Wonogiri Prosecutor's Office? This study uses empirical legal research methods. The results of this study indicate that the implementation of the stages of prosecuting criminal cases (online) in order to realize the principles of fast, simple and low-cost justice at the Wonogiri Prosecutor's Office is carried out with Supreme Court Regulation (PERMA) No. 1 of 2019 concerning Administration and Trial in Courts Electronically. Implementation constraints in the application of (online) prosecution of criminal cases due to legal factors, Cultural Community facilities and infrastructure. The ideal implementation of the application of online criminal prosecution in order to realize the principles of fast, simple and low-cost justice at the Wonogiri Prosecutor's Office requires clear arrangements, human resources who have IT skills. Internet Network,�a good understanding of the law intensively conduct outreach to the community.

Pros and Cons of Online Criminal Case Settlement During the Covid-19 Pandemic: Study on Islamic Criminal Law

The online criminal trial discourse has become a hot discussion topic by criminal law practitioners, especially regarding the obscenity case in Petamburan that involved the suspect, HRS. HRS himself and his lawyer refused to hold the online trial for being contrary to the Criminal Procedure Code (KUHAP) although there is a Memorandum of Understanding between the Supreme Court, Attorney General's Office, Police, and the Directorate General (Ditjen) of Corrections regarding the Implementation of Criminal Trial Proceedings via video conferencing as efforts to prevent the spread of Covid-19 on April 13, 2020. This study aims to provide an answer that Islamic criminal procedural law can accommodate models of virtual criminal case resolution because it considers emergency situations. Moreover, the reason for the emergency has to do with humanity. The data used as materials for data analysis was library research which were taken from fiqh books, written documents, laws and other regulations. The results show that Islamic criminal law can consider its feasibility.Keywords: Virtual criminal court – Islamic criminal

Single versus combination intravenous anti-pseudomonal antibiotic therapy for people with cystic fibrosis.

The choice of antibiotic, and the use of single or combined therapy are controversial areas in the treatment of respiratory infection due to Pseudomonas aeruginosa in cystic fibrosis (CF). Advantages of combination therapy include wider range of modes of action, possible synergy and reduction of resistant organisms; advantages of monotherapy include lower cost, ease of administration and reduction of drug-related toxicity. Current evidence does not provide a clear answer and the use of intravenous antibiotic therapy in CF requires further evaluation. This is an update of a previously published review. To assess the effectiveness of single compared to combination intravenous anti-pseudomonal antibiotic therapy for treating people with CF. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register, comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. Most recent search of the Group's Trials Register: 07 October 2020. We also searched online trials registries on 16 November 2020. Randomised controlled trials (RCTs) comparing a single intravenous anti-pseudomonal antibiotic with a combination of that antibiotic plus a second anti-pseudomonal antibiotic in people with CF. Two authors independently assessed trial quality and extracted data. We assessed the certainty of the data using GRADE. We identified 59 trials, of which we includedeight trials (356 participants) comparing a single anti-pseudomonal agent to a combination of the same antibiotic and one other.There was a wide variation in the individual antibiotics used in each trial. In total, the trials included seven comparisons of a beta-lactam antibiotic (penicillin-related or third generation cephalosporin) with a beta-lactam-aminoglycoside combination and three comparisons of an aminoglycoside with a beta-lactam-aminoglycoside combination. There was considerable heterogeneity amongst these trials, leading to difficulties in performing the review and interpreting the results.These results should be interpreted cautiously. Six of the included trials were published between 1977 and 1988; these were single-centre trials with flaws in the randomisation process and small sample size. Overall, the methodological quality was poor and the certainty of the evidence ranged from low to moderate. The review did not find any differences between monotherapy and combination therapy in either the short term or in the long term for the outcomes of differentlung function measures,bacteriological outcome measures, need for additional treatment, adverse effects, quality of life or symptom scores. The results of this review are inconclusive. The review raises important methodological issues. There is a need for an RCT which needs to be well-designed in terms of adequate randomisation allocation, blinding, power and long-term follow-up. Results need to be standardised to a consistent method of reporting, in order to validate the pooling of results from multiple trials.

Legal Protection of the Rights of the Defendant in Criminal Trials through Electronic Media

The Covid19 pandemic also affected the law enforcement process in Indonesia, including the law enforcement process in court. In the online trial, the problem is how the position / existence of the judge who should be able to control the trial process who is not in the same room as the defendant. It is feared that the existence of this difference in location will result in the weakening of the judge's decision making to be able to dig deeply the hidden truths in a case. Operational constraints in the availability of an internet connection also have the potential to become a problem in the implementation of criminal proceedings. Trials with electronic media are one of the modern legal solutions that cannot be avoided along with the advancement of the digital world and globalization. Even so, the rights of the defendant in the trial using electronic media must also be guaranteed protection for the sake of upholding justice in the law. This type of research is normative juridical legal research. The normative juridical approach is a research that examines the study of documents, namely using various secondary data such as statutory regulations, court decisions, legal theory, and it can be in the form of the opinions of scholars. Legal protection for the defendant in a trial using electronic media is regulated in the Supreme Court Regulation No. 4 of 2020 concerning Electronic Administration and Trial of Criminal Cases in Courts. Legal protection for the rights of the defendant has been regulated in Law Number 8 of 1981 concerning Criminal Procedure Law in articles 50 to Article 68. In addition, legal protection for the rights of the accused as stipulated in the Universal Declaration of Human Rights (DUHAM) also applies. .

An assessment of the NAVIFY clinical trial match application using clinical simulation-based research methods.

e13552 Background: Cancer clinical trials require matching patients to strict, and sometimes lengthy, eligibility criteria. NAVIFY Clinical Trial Match (CTM) is a digital solution that uses data on an individual patient’s condition, genomic alterations and institution’s postal code to automatically find suitable clinical trials. We assessed the efficiency, accuracy and cognitive burden of NAVIFY CTM on matching patients to cancer clinical trials in the UK. Methods: 10 clinicians (8 medical doctors, 2 clinical trial practitioners) participated. Synthetic patient cases were developed with input from two oncologists, a histopathologist and a radiologist. Participants were instructed to identify appropriate trials for five patients using the NAVIFY CTM and five patients with the legacy approach (i.e. online trial databases) within one hour. For each method, participants were advised to approach the exercise with the level of scrutiny employed in a normal clinical setting. The efficiency, quality, and cognitive burden of trial matching was measured for each participant. The quality of trial matches was independently scored by an oncologist who did not participate in the simulations. The cognitive burden was measured subjectively, via a single-item questionnaire used to measure mental effort (Paas scale), and objectively, via Stroop test before and after each method. A survey was also conducted. Results: Efficiency: Participants completed the trial matching more efficiently using NAVIFY CTM, with trial matches completed on average one minute and 42 seconds faster using the digital solution (n = 73 matches) compared with the most commonly used online trial database, ClinicalTrials.gov (n = 52). Participants were more likely to ‘completely agree’ that they had enough time to complete the task using the NAVIFY CTM (70%) compared to online trial databases (40%). Quality of the matches: On the survey, more participants reported that trial suggestions were ‘mostly relevant’ for NAVIFY CTM (70%) compared with ClinicalTrials.gov (30%). The quality of trial matches was the same for both methods (as scored independently by an oncologist). Cognitive burden: On the subjective measure of cognitive burden, more participants required ‘low’ or ‘rather low’ mental effort to use NAVIFY CTM (50%) compared to online trial databases (7%). On the objective measure, there is a seemingly less pronounced Stroop effect (often interpreted as higher mental agility) using NAVIFY CTM vs. legacy approach. Conclusions: Preliminary findings suggest that, compared to online trial databases, the NAVIFY CTM can reduce the amount of time to match patients to clinical trials, provide more relevant trial suggestions, and decrease self-reported mental effort for the decision-maker.

A novel energy management method based on Deep Q Network algorithm for low operating cost of an integrated hybrid system

For minimizing the operational cost of an integrated hybrid system, which provides electricity, heating, cooling and water of a residential complex, a new energy management method presented here. The proposed energy management method uses the principles of Reinforcement Learning (RL) based on Deep Q Network (DQN) algorithm to find the operational strategy for the hybrid system. Unlike the stochastic presentation of RL with Markov Decision Process (MDP) in literature, a deterministic approach proposed in this study for energy management of a hybrid system. This presented approach does not require online trial and error or historical data of system performance to determine the operational strategy. This developed RL-DQN method used for energy management of a hybrid system with photovoltaic collectors, ET collectors, wind turbines, CHP units, a water heater, a hot water storage tank and batteries. Thus for a residential complex with variable electrical and thermal loads during a year (8760 h), RL-DQN energy management method estimated two unknown variables in operational strategy, i.e., the partial load of the CHP unit and the amount of heat generation by LPG-fueled water heater. The results of RL-DQN energy management also compared with results of two rule-based methods. The results show a reduction of the operating cost to 10983 $/year by RL-DQN which is lower 6.5% and 30.4% than that for two above mentioned rule-based methods. Lower CO2 production (2.8% and 62.8%) also observed in comparison with that for two above mentioned rule based methods. With the proposed EM method, 80.1% of the required electricity supplied with renewable energies and 82.2% of the thermal load supplied without direct consumption of fossil fuels. The benefit of using predicted load and renewable energies of future hours also investigated for EM. Results show that employing the predicted information decrease the operational cost by about 3.5 percent

Liar! Liar! Identifying eligibility fraud by applicants in digital health research

Online studies enable researchers to recruit large, diverse samples, but the nature of these studies provides an opportunity for applicants to misrepresent themselves to increase the likelihood of meeting eligibility criteria for a trial, particularly those that provide financial incentives. This study describes rates of fraudulent applications to an online intervention trial of an Internet intervention for insomnia among older adults (ages ≥55). Applicants were recruited using traditional (e.g., flyers, health providers), online (e.g., Craigslist, Internet searches), and social media (e.g., Facebook) recruitment methods. Applicants first submitted an interest form that included identifying information (name, date of birth, address). This data was then queried against a national database (TransUnion's TLOxp) to determine the application's verification status. Applications were determined to be verified (i.e., information from interest form matched TLOxp report), potentially fraudulent (i.e., potential discrepancy in provided information on interest form versus TLOxp report), or fraudulent (i.e., confirmed discrepancy). Of 1766 total interest forms received, 125 (7.08%) were determined to be fraudulent. Enrollment attempts that were fraudulent were detected among 12.22% of applicants who reported learning of the study through online, 7.04% through social media, 4.58% through traditional, and 4.27% through other methods. Researchers conducting online trials should take precautions, as applicants may provide fraudulent information to gain access to their studies. Reviewing all applications and verifying the identities and eligibility of participants is critical to the integrity of online research trials.

Hematopoietic stem cell transplantation for people with β-thalassaemia.

Thalassaemia is anautosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions, resulting ina reduced rate of synthesis of one of the globin chains that make up haemoglobin. In β-thalassaemia there is an underproduction of β-globin chains combined with excess of free α-globin chains. The excess free α-globin chains precipitate in red blood cells, leading to their increased destruction (haemolysis) and ineffective erythropoiesis. The conventional treatment is based on the correction of haemoglobin through regular red blood cell transfusions and treating the iron overload that develops subsequently with iron chelation therapy. Although, early detection and initiations of such supportive treatment has improved the quality of life for people with transfusion-dependent thalassaemia, allogeneic hematopoietic stem cell transplantation is the only widely available therapy with a curative potential. Gene therapy for β-thalassaemia has recently received conditional authorisation for marketing in Europe, and may soon become widely available as another alternative therapy with curative potential for people with transfusion-dependent thalassaemia. This is an update of a previously published Cochrane Review. To evaluate the effectiveness and safety of different types of hematopoietic stem cell transplantation, in people with transfusion-dependent β-thalassaemia. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register comprising references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings. We also searched online trial registries. Date of the most recent search: 07 April 2021. Randomised controlled trials and quasi-randomised controlled trials comparing hematopoietic stem cell transplantation with each other or with standard therapy (regular transfusion and chelation regimen). Two review authors independently screened trials and had planned to extract data and assess risk of bias using standard Cochrane methodologies and assess the quality using GRADE approach, but no trials were identified for inclusion in the current review. No relevant trials were retrieved after a comprehensive search of the literature. We were unable to identify any randomised controlled trials or quasi-randomised controlled trials on the effectiveness and safety of different types of hematopoietic stem cell transplantation in people with transfusion-dependent β-thalassaemia. The absence of high-level evidence for the effectiveness of these interventions emphasises the need for well-designed, adequately-powered, randomised controlled clinical trials.

Mindfulness-Based Online Intervention to Improve Quality of Life in Late-Stage Bipolar Disorder a Randomised Clinical Trial

Background: Adjunctive psychological interventions improve outcomes in bipolar disorder (BD), but people in latter, more refractory illness stages likely have different clinical needs. The objective here was to test the hypothesis that for people with >‾ 10 episodes of BD, an online mindfulness-based intervention improves quality of life (QoL) relative to a quality-matched psychoeducation control. Methods: A rater-blind, pragmatic superiority randomised clinical trial compared Mindfulness with active control (Psychoeducation). Both interventions were 5-week coach-supported self-management programs with treatment as usual continued. Key inclusion criteria were age 18 to 65 years, confirmed diagnosis of BD, and history of >‾ 10 episodes. Measures were collected at baseline, immediate post-intervention, and 3- and 6- month follow-ups. Main outcome was QoL, measured on the self-report Brief Quality of Life in Bipolar Disorder (Brief QoL.BD) at 5 weeks, using intention-to-treat analyses. The study setting was online, and randomisation was automated into the platform. The trial was prospectively registered on 23 June 2017 through ClinicalTrials.gov (http://www.clinicaltrials.gov, NCT03197974). Findings: Recruitment commenced 19 th September 2017, randomisation target reached 28 th November 2018 (N = 302 randomised) and follow-up data collection completed 6 th July 2019. The primary hypothesis of significant improvement in QoL with Mindfulness relative to Psychoeducation was not supported (Treatment X Time β = -0.69, 95% CI: -2·69, 1·31, p = 0·50). Recruitment was feasible, the platform was safe, both interventions were highly acceptable, but usage was suboptimal. Post hoc analyses found both interventions effective for participants not in remission from depression at baseline. Interpretation: In people with latter-stage BD, an online Mindfulness intervention was not superior to Psychoeducation. More effective future variants could combine mindfulness with psychoeducation content, improve engagement via personalised tailoring of QoL goals, and target more symptomatic individuals. Trial Registration: The trial was prospectively registered on 23 June 2017 through ClinicalTrials.gov (http://www.clinicaltrials.gov, NCT03197974). Funding: Supported by Australian National Health and Medical Research Council (NHMRC; APP1102097). Declaration of Interest: GM has received Grant/Research support from National Health and Medical Research Council (NHMRC), BeyondBlue Barbara Dicker Foundation, Readiness P/L, SiSU Wellness P/L – unrelated to this work, with the exception of the NHMRC funding for the project described here. MB has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, Medical Benefits Fund, National Health and Medical Research Council, Medical Research Futures Fund, Beyond Blue, Rotary Health, A2 milk company, Meat and Livestock Board, Woolworths, Avant and the Harry Windsor Foundation, has been a speaker for Abbot, Astra Zeneca, Janssen and Janssen, Lundbeck and Merck and served as a consultant to Allergan, Astra Zeneca, Bioadvantex, Bionomics, Collaborative Medicinal Development, Janssen and Janssen, Lundbeck Merck, Pfizer and Servier – all unrelated to this work. NT has received Grant/Research Support from the Australian Government Department of Health, Australian Government Department of Veterans Affairs, Barbara Dicker Brain Sciences Foundation, NHMRC, Mental Health Commission, VicHealth and Victorian State Government Department of Health and Human Services, all unrelated to this work. LB has received Grant/Research Support from the NIH, Australasian Society for Bipolar & Depressive Disorders Ltd, GMHBA, National Health and Medical Research Council, and Servier – all unrelated to this work. SJ has received Grant/Research support from NIHR HTA, EME, RfPB and PGfAR streams all unrelated to this work. Ethical Approval: Swinburne University of Technology Human Research Ethics Committee approved the online trial (2016/289) with international recruitment.

A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars.

The objective of this article is to study the clinical efficacy and adverse events of laser-assisted drug delivery in the treatment of hypertrophic and keloid scars. We searched the following databases up to 22 October 2020: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (Clinical Trials) in The Cochrane Library, MEDLINE, EMBASE, and reference lists of articles for randomised clinical trials (RCTs) of laser-assisted drug delivery for the treatment of hypertrophic and keloid scars. We also searched online trials registries for ongoing trials and contacted trial authors where appropriate. Our outcomes of interest were objective clinical evaluation of scars, participant satisfaction, and adverse effects of the treatments. Two authors independently extracted data and assessed trial quality using Cochrane Risk of Bias 2. Two authors independently abstracted data. We included 10 RCTs involving a total of 329 participants: six trials utilised parallel-arm RCTs whilst four employed split-scar design. Three trials had high risk of bias with the remaining seven rated as having some concerns. The interventions and outcomes were too varied to be combined statistically. High-quality randomised controlled trials assessing laser-assisted delivery for drugs in the context of hypertrophic and/or keloid scarring are needed. Studies with a larger number of participants, with longer follow-up times, and standardised evaluation of outcome and adverse effects are warranted.

A Novel Mobile App (Heali) for Disease Treatment in Participants With Irritable Bowel Syndrome: Randomized Controlled Pilot Trial.

BackgroundA diet high in fermentable, oligo-, di-, monosaccharides and polyols (FODMAPs) has been shown to exacerbate symptoms of irritable bowel syndrome (IBS). Previous literature reports significant improvement in IBS symptoms with initiation of a low FODMAP diet (LFD) and monitored reintroduction. However, dietary adherence to the LFD is difficult, with patients stating that the information given by health care providers is often generalized and nonspecific, requiring them to search for supplementary information to fit their needs.ObjectiveThe aim of our study was to determine whether Heali, a novel artificial intelligence dietary mobile app can improve adherence to the LFD, IBS symptom severity, and quality of life outcomes in adults with IBS or IBS-like symptoms over a 4-week period.MethodsParticipants were randomized into 2 groups: the control group (CON), in which participants received educational materials, and the experimental group (APP), in which participants received access to the mobile app and educational materials. Over the course of this unblinded online trial, all participants completed a battery of 5 questionnaires at baseline and at the end of the trial to document IBS symptoms, quality of life, LFD knowledge, and LFD adherence.ResultsWe enrolled 58 participants in the study (29 in each group), and 25 participants completed the study in its entirety (11 and 14 for the CON and APP groups, respectively). Final, per-protocol analyses showed greater improvement in quality of life score for the APP group compared to the CON group (31.1 and 11.8, respectively; P=.04). Reduction in total IBS symptom severity score was 24% greater for the APP group versus the CON group. Although this did not achieve significance (–170 vs –138 respectively; P=.37), the reduction in the subscore for bowel habit dissatisfaction was 2-fold greater for the APP group than for the CON group (P=.05).ConclusionsThis initial study provides preliminary evidence that Heali may provide therapeutic benefit to its users, specifically improvements in quality of life and bowel habits. Although this study was underpowered, findings from this study warrant further research in a larger sample of participants to test the efficacy of Heali app use to improve outcomes for patients with IBS.Trial RegistrationClinicalTrials.gov NCT04256551; https://clinicaltrials.gov/ct2/show/NCT04256551

The effect of online multimedia psychoeducational interventions on the resilience and perceived stress of hospitalized patients with COVID-19: a pilot cluster randomized parallel-controlled trial

BackgroundThere is evidence suggesting that quarantine might have undesirable psychological impacts on the patients. Therefore, it is important to seek for ways to increase the resilience and alleviate the psychological pressure of the patients who are quarantined due to infection with COVID-19. The present study was conducted to assess an online multimedia psychoeducational intervention regarding the feasibility, adherence, patient satisfaction and effectiveness on resilience and perceived stress of patients hospitalized with confirmed COVID-19.MethodThis was a pilot cluster randomized parallel-controlled trial with hospital wards as the units of randomization. Participants in this fully online trial were 50 consecutive patients who were hospitalized in 2 hospitals in Shiraz, after being diagnosed with COVID-19. Before the beginning of the intervention, four inpatient wards inside two of the hospitals were randomly assigned to either intervention or control conditions. All eligible participants in the wards allocated to the intervention condition received online multimedia psychoeducational interventions during the 2 weeks, whilst the patients in the wards allocated to the control condition were offered the opportunity to receive telephone-based psychological counseling if needed. Psychoeducational interventions mainly included cognitive–behavioural techniques, stress management techniques, mindfulness-based stress reduction and positive psychotherapy. The patients were assessed regarding resilience and perceived stress at baseline and after two weeks.ResultsOf 27 patients starting multimedia psychoeducational interventions, 26 (96.29%) completed post-assessments. A high level of adherence (80.76%) and satisfaction (Mean = 29.42; SD = 4.18) with the online multimedia psychoeducational interventions was found. Compared with the control group, the patients who used online multimedia psychoeducational interventions reported greater resilience (Meanintervention = 81.74; Meancontrol = 72.86; adjusted t (46) = 2.10; p = 0.04; CI: 0.39 to 17.38; dppc2 = 0.83) and fewer perceived stress (Meanintervention = 22.15; Meancontrol = 29.45; adjusted t (46) = 2.66; p = 0.01; CI: − 12.81 to − 1.78; dppc2 = − 0.77) after 2 weeks.DiscussionThe findings of the present study provided a successful first attempt at implementing feasible online multimedia psychoeducational interventions to promote resilience and mitigate stress among the patients who were hospitalized due to infection with COVID-19. The present results could help mental health professionals to determine which psychological techniques should be emphasized to promote patients’ resilience in the context of COVID-19 disease.Trial registrationIranian Registry of Clinical Trials, IRCT20201001048893N1. Retrospectively registered, 29 Jan 2021.

LAW ENFORCEMENT IN THE DEVELOPMENT CRIMINAL JURISDICTION SYSTEM IN INDONESIA UPHOLDING PANCASILA AND HUMAN RIGHTS VALUES

Law enforcement is the basis for the implementation of the criminal justice system in Indonesia with human rights values protected in the 1945 Constitution, Act No. 8 of 1981 Criminal Procedure Law, Act No. 39 of 1999 about Human Rights, Act No. 12 of 2005 about Ratification of International Convention of Civil and Political Rights and related regulation. Development of criminal justice is not regulated by various evidentiary procedures such as wiretapping, the process of resolving criminal case outside the court, online trials, so it is necessary for discussing: 1. How is development of criminal justice in Indonesia?; 2. How are the regulations in the development of the criminal justice in Indonesia while still human rights values?. The purposes are to analyzing the development of criminal justice in Indonesia and regulation still Pancasila and human rights values. The method used is juridical normative with literature study and analysis descriptive qualitative by describing development of the criminal justice system still human rights values. The development of criminal justice are proof by wiretapping, online trials, regulation about settlement of criminal cases out of court to reduce the convicts, justice collaborators, the extistence of checks and balances mechanisms between law enforcers. The criminal procedure code has not regulate the developmen of the criminal justice. Suggestions that development of the criminal justice should be received by upholding human rights values. So that the criminal procedure drafter to accomadate development of criminal cases and Criminal Code Bill. Keywords: Law Enforcement, Criminal Justice, Human Rights .

THE IMPACT OF COVID-19 PANDEMICON EDUCATION AND JUDICIAL PRACTICEIN INDONESIA

The corona virus has made fundamental changes to educational and legal practices in Indonesia. The large number of Covid-19 cases that have occurred in Indonesia makes holding state policies must be active to tackle the spread of this deadly virus, one of which is changing the pattern and model of education including trial administration using online media depending on the zone categorization set by the government. This paper finds out what happened during the Indonesian pandemic. First, in education, the emergence of covid-19 has made significant changes in the learning process by utilizing online learning media, and students are starting to be sent home, including in the context of higher education. Second, in the field of justice , trial administration in a number of courts is still carried out with due observance of health protocols, some trials are also conducted using an online trial model using various media, so that the law enforcement process continues. This paper also explains that the Covid-19 pandemic has become the center of serious attention of the government, including in providing education and implementing judicial processes in the world of law in Indonesia. Or in other words that even in the midst of a pandemic, activities must continue in various aspects, especially during the new normal era.

Participant views and experiences of sexual health research: The Contraception Choices online trial.

BackgroundOnline sexual health research can be convenient, efficient and low cost, but there are debates about the adequacy of online informed consent, privacy, and the acceptability of different methods of follow-up.ObjectivesTo explore women's views and experiences of the Contraception Choices feasibility trial procedures and the place of digital interventions for contraception decision making.MethodsWe analysed data from two sources: (1) Qualitative interviews. Eighteen interviews were conducted with women who had taken part in the Contraception Choices pre-trial feasibility study, to evaluate recruitment and online trial procedures. (2) Free-text comments. Women in the main Contraception Choices randomised controlled trial were followed up at 3 and 6 months, and asked ‘Please tell us what you liked or disliked about the website’ and ‘Has being in the study had any good or bad effects on your life?’ A total of 387 and 414 comments were made at 3 and 6 months respectively. Data were analysed thematically.ResultsParticipants liked being involved in a study about contraception, although recruitment from an abortion clinic was less acceptable than in other sexual health settings. Women found the trial procedures straightforward, and expressed no major concerns about online self-registration, informed consent or online data collection. Online survey questions about contraception and fertility were acceptable, and participants liked the convenience of being followed up by email or text.ConclusionsParticipants appreciated the advantages of the online research design and did not express concerns about consent or privacy. Women would welcome digital interventions for contraception in a variety of settings.

Management of Criminal Cases Online Trials to Realize the Principles of Fast and Low Cost Justice System at the Tangerang District Court

Management of Criminal Cases Online Trials to Realize the Principles of Fast and Low Cost Justice System at the Tangerang District Court

Virtual Poverty? What Happens when Criminal Trials Go Online?

The challenge posed by the editors of this collection is for authors to reflect on what good can come out of the pandemic. This is far from easy to address in the context of ever more evidence of a divided polity, but this chapter will look at the rapid rise in the use of video hearings caused by the pandemic and their potential to improve the lot of the poor. Academics, including myself, have been sceptical about the extent to which the needs of lay users and open justice are served when technology is used to circumvent the need for everyone to come to a physical court. What is different about developments during the pandemic is that they have prompted experiments in which everyone including elite legal actors have been forced online and made to reflect on the experience. In the sections which follow I outline developments to date before going on to consider the extent to which totally online trials have the potential to create a more level playing field in the criminal justice system. In doing so I argue that there is a danger that critics of the use of technology are in danger of romanticising physical courthouses as places which are better at dignifying lay users of the justice system or encouraging their participation.