Online Databases Research Articles

A five-gene prognosis model based on lysine β-hydroxybutyrylation site genes to predict the survival and therapy response in pancreatic adenocarcinoma

BackgroundPancreatic adenocarcinoma (PAAD) is one of the most malignancy diseases. Lysine β-hydroxybutyrylation (Kbhb) has been reported to involve various metabolism and cancer progression. MethodsData from online databases (TCGA and GEO) were retrieved for the selection of differential expressed Kbhb site genes (DTRGs). Univariate cox and LASSO analysis were performed to identified the prognostic DTRGs. Based on the optimal DTRGs, a prognostic risk score model was established. Kaplan-Meier and Receiver operator characteristic analysis were conducted to evaluate the predicting ability of the prognosis model. Generated with clinical data, independent analysis and nomogram model were performed. Finally, the difference of survival, immune cell levels, immunotherapy response, drug sensitivity between high- and low-risk groups were explored. ResultsA total of 63 DTRGs were identified in PAAD, and these genes were related to cell division and apoptosis biological functions. Through univariate cox regression and LASSO analysis, 30 DTRGs were selected to be related to prognosis and five (KRT18, ANLN, ECT2, RBM5, and RBM6) were identified as the optimal DTRGs in PAAD. Based on the five optimal DTRGs, a prognostic risk score model was constructed, with promising predictive ability in PAAD survival (AUC > 0.70). High-risk group showed lower survival rate (P < 0.05). Moreover, based on the risk score, a nomogram model was also established, which possessed perfect stability. Finally, lower risk score was related to higher immune cell levels, indicating an immune activation in low-risk status, which maybe the reason for the better survival in low-risk group. Furthermore, the immunotherapy response and drug sensitivity were all higher than that in low-risk groups (P < 0.05). ConclusionA five-gene prognosis risk model which exhibit promising predictive ability in survival is constructed for patients with PAAD.

Danggui-Shaoyao-San protects against non-alcoholic steatohepatitis via modulation of hepatic APP protein, Lysosomal CTSB release, and NF-κB activation

BackgroundNon-alcoholic steatohepatitis (NASH), an escalating global health concern, is a primary factor behind cirrhosis, liver transplantation, and hepatocellular carcinoma. Effective treatments remain elusive. Danggui-Shaoyao-San (DGSY), a classic famous prescription employed in treating NASH, could hold promise, although its molecular underpinnings are still under investigation. This study undertakes an exploration of the impacts of DGSY on NASH and seeks to illuminate the mechanisms at play. MethodsUHPLC-Q-Orbitrap HRMS was employed to identify compounds within DGSY. Mice underwent a 25-week regimen of HFHC diet and high-sugar water, with 4 weeks of DGSY treatment for efficacy and pathogenic mechanism exploration in vivo. L02 cells were cultured with 0.2 mM FFA for 24 h, exposed to DGSY at 1 mg/ml and 2 mg/ml for efficacy and pathogenic mechanism exploration in vitro. Using online databases, we sought potential targets for NASH treatment, and through PPI networks, identified key targets. Expression levels of genes and proteins were examined by western blotting, RT-PCR, and immunofluorescence staining. ResultsThirty-four compounds were identified within DGSY. DGSY brought about marked reductions in biochemical indicators and yielded significant improvements in NASH mice histological features. Additionally, it mitigated hepatic steatosis and inflammation both in vivo and in vitro. The top 10 targets from two network pharmacology analyses, one focusing on structural prediction and the other on literature mining, identified APOE and APP as potential therapeutic targets for DGSY in NASH treatment. PCR validation confirmed that DGSY reduced APP expression after treatment, and further investigation revealed that DGSY significantly suppressed hepatic APP and Aβ expression, indicating its effectiveness in treating NASH. Furthermore, it inhibited Aβ-induced Cathepsin B lysosomal release, reducing hepatic inflammation. ConclusionDanggui-Shaoyao-San has anti-steatohepatitis effects in ameliorating hepatic APP protein expression, reducing hepatic lysosomal CTSB release, and suppressing hepatic NF-κB activation. The study provided a more theoretical basis for the future clinical application of DGSY.

Cementless TKA use as an alternative to cemented TKA in high BMI patients: A systematic review and meta-analysis.

Obesity is prevalent, with nearly one-third of the world's population being classified as obese. In patients with high body mass index (BMI)/body mass undergoing total knee arthroplasty (TKA), there is an increase in strain placed on the implant fixation interfaces. As such, component fixation is a potential concern when performing TKA in the obese patient. To address the growing concerns around the longevity of implant fixation, some have advocated cementless over cemented fixation. However, there is no clear consensus on whether a cementless fixation has more favourable outcomes. The aim of this paper was to present a systematic review and meta-analysis of the existing evidence to establish if cementless TKA has a lower rate of aseptic loosening in high BMI patients when compared to cemented TKA procedures. A systematic review was performed, and the following databases Medical Literature Analysis and Retrieval System Online (1946 to date), PubMed (1966 to date) and Excerpta Medica Database (1974 to date) were searched. All studies comparing cementless to cemented TKA in patients with BMI > 30 were considered. Meta-analysis compared aseptic loosening and all-cause revision between cemented and uncemented implant use in BMI > 30 patients. The search returned 91 articles in total; after duplicates were removed, the yield was 44 studies. Of the remaining studies that were assessed, three studies met the inclusion criteria for meta-analysis. The pooled odds ratio for all-cause revisions was 0.17 (95%, 0.08-0.36) in favour of uncemented implants (p < 0.01). The pooled odds ratio for aseptic loosening was 0.15 (95% confidence interval, 0.02-0.90) in favour of uncemented implants (p = 0.04). Meta-analysis demonstrated a significant decrease in all-cause revisions and revisions for aseptic loosening when using uncemented fixation in high BMI patients when compared to the use of cemented implants. The level of evidence is 1 for our systematic review.

"Still work?" Design and effect of interventions used to modify feeding problems in children with autism: A systematic review of studies employing group designs.

Feeding problems in children with autism jeopardize the well-being of both children with autism and their families. Mixed findings were reported from previous interventions, which were mostly evaluated by single subject research design (SSRD) studies. Moreover, feasibility assessment and social validity measurement were unaddressed by these SSRD studies. To fill this substantial knowledge gap, the present review systematically summarized and evaluated feeding interventions implemented in children with autism, which were assessed by studies employing group designs. An extensive literature search in eight established online databases was conducted, and a total of 17 eligible studies published in 2009-2021 were included for further analysis. A descriptive account of the features of the investigations is provided, including assessment of study quality. A total of 449 children with autism and 203 parents/caregivers participated in the included studies. The multiple use of five strategic intervention components were highlighted in this review, including nutrition education/consultations, environmental modifications, sensory exposure, cognitive components, and behaviour interventions. The reviewed interventions showed a preliminarily positive effect for modifying feeding problems in children with autism. Furthermore, the evaluation based on the RE-AIM framework (reach, efficacy, adoption, implementation, and maintenance) demonstrated that an interdisciplinary multi-component intervention strategy may achieve high effectiveness and feasibility in improving feeding problems in a wide range of children with autism. This review found that interventions achieved and maintained a positive effect on modification of feeding problems in groups of children with autism. Information and gaps identified and summarized in the implementation process may assist both researchers and stakeholders to further support these vulnerable children.

Diabetes, glycemic profile and risk of vitiligo: A Mendelian randomization study.

Previous observational studies have shown that vitiligo usually co-manifests with a variety of dysglycemic diseases, such as Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM). Mendelian randomization (MR) analysis was performed to further evaluate the causal association between fasting plasma glucose, glycosylated hemoglobin (HbA1c), T1DM, T2DM and vitiligo. We used aggregated genome-wide association data from the Integrative Epidemiology Unit (IEU) online database of European adults vitiligo; HbA1c data were from IEU. Fasting blood glucose data were obtained from the European Bioinformatics Institute (EBI). T1DM and T2DM data were from FinnGen. We used bidirectional two-sample and multivariate MR analyses to test whether dysglycemic measures (fasting blood glucose, HbA1c), diabetes-related measures (T1DM, T2DM) are causatively associated with vitiligo. Inverse variance weighting (IVW) method was used as the main test method, MR-Egger, Weighted mode and Weighted median were used as supplementary methods. We found no statistically significant evidence to support a causal association between dysglycemic traits and vitiligo, but in the correlation analysis of diabetic traits, our data supported a positive causal association between T1DM and vitiligo (p=0.018). In the follow-up multivariate MR analysis, our results still supported this conclusion (p=0.016), and suggested that HbA1c was not a mediator of T1DM affecting the pathogenesis of vitiligo. No reverse causality was found in any of the reverse MR Analyses of dysglycemic traits and diabetic traits. Our findings support that T1DM is a risk factor for the development of vitiligo, and this conclusion may explain why the co-presentation of T1DM and vitiligo is often seen in observational studies. Clinical use of measures related to T1DM may be a new idea for the prevention or treatment of vitiligo.

Implementation of E-Health Based Technology to Improve the Health Status of the Elderly: A Literature Review

The number of elderly from year to year continues to increase, this has a significant impact on health services. The significant addition of the elderly and the worsening of the situation including decreased health, altered emotional status, inability to do activities independently make some people consider the elderly a burden. Objective: Providing ideas and ideas from the results of literature review on the implementation of E-health-based technology to improve the health status of the elderly, using smartphones to measure elderly activities, security and safety of the elderly. The method used in this research is literature review with keywords namely "technology", "elderly", and "degree of health". Searching for academic journals through Online Databases including: Science Direct, Google Scholar, ProQuest and clinical key from 2015-2022. The results of the review of 10 journals that discuss the technology of monitoring the elderly remotely via smartphones can be concluded if the development of technology to monitor the development of the elderly remotely is very satisfying because it can help caregivers and health workers in monitoring activities, the state of the elderly, and minimizing adverse events. It is hoped that future researchers can examine the ability of users to apply technology and user preparedness and costs in using this technology.

Climate change and health in the Sahel: a systematic review.

The Sahel region is projected to be highly impacted by the more frequent hazards associated with climate change, including increased temperature, drought and flooding. This systematic review examined the evidence for climate change-related health consequences in the Sahel. The databases used were Medline (PubMed), Embase (Ovid), Web of Science (Clarivate) and CABI Global Health. Hand searches were also conducted, which included directly engaging Sahelian researchers and hand-searching in the African Journals Online database. Of the 4153 studies found, 893 were identified as duplicates and the remaining 3260 studies were screened (title and abstract only) and then assessed for eligibility. A total of 81 studies were included in the systematic review. Most studies focused on vector-borne diseases, food security, nutrition and heat-related stress. Findings suggest that mosquito distribution will shift under different climate scenarios, but this relationship will not be linear with temperature, as there are other variables to consider. Food insecurity, stunting (chronic malnutrition) and heat-related mortality are likely to increase if no action is taken owing to the projected impact of climate change on environmental factors and agriculture. Seventy-one per cent of manuscripts (n = 58) had first authors from institutions in North America or Europe, of which 39.7% (n = 23) included co-authors from African institutions.

Unraveling morphology, methylation profiling, and diagnostic challenges in BRAF-Mutant pediatric glial and glioneuronal tumors.

To elucidate the relationship between DNA methylation profiling (DMP) and pathological diagnosis (PD) in pediatric glial and glioneuronal tumors with B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations, addressing their diagnostic challenges. This retrospective study, conducted in Saudi Arabia, analyzed 47 cases from the Children's Brain Tumor Network online database using scanned images, next-generation sequencing data, and methylation profiles processed using the Heidelberg methylation brain tumor classifiers v12.5 and v12.8. The data was last access on 10 November 2023. The highest prevalence of BRAF mutations was observed in pilocytic astrocytoma and ganglioglioma. The DMP was consistent with PD in 23 cases, but discrepancies emerged in others, including diagnostic changes in diffuse leptomeningeal glioneuronal tumor and polymorphous low-grade neuroepithelial tumor of the young. A key inconsistency appeared between a pilocytic astrocytoma MC and a glioneuronal tumor PD. Two high-grade astrocytomas were misclassified as pleomorphic xanthoastrocytomas. Additionally, low variant allelic frequency in gangliogliomas likely contributed to misclassifications as control in 5 cases. This study emphasized the importance of integrating DMP with PD in diagnosing pediatric glial and glioneuronal tumors with BRAF mutations. Although DMP offers significant diagnostic insights, its limitations, particularly in cases with low tumor content, necessitate cautious interpretation, as well as its use as a complementary diagnostic tool, rather than a definitive method.

Unraveling morphology, methylation profiling, and diagnostic challenges in BRAF-Mutant pediatric glial and glioneuronal tumors.

To elucidate the relationship between DNA methylation profiling (DMP) and pathological diagnosis (PD) in pediatric glial and glioneuronal tumors with B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations, addressing their diagnostic challenges. This retrospective study, conducted in Saudi Arabia, analyzed 47 cases from the Children's Brain Tumor Network online database using scanned images, next-generation sequencing data, and methylation profiles processed using the Heidelberg methylation brain tumor classifiers v12.5 and v12.8. The data was last access on 10 November 2023. The highest prevalence of BRAF mutations was observed in pilocytic astrocytoma and ganglioglioma. The DMP was consistent with PD in 23 cases, but discrepancies emerged in others, including diagnostic changes in diffuse leptomeningeal glioneuronal tumor and polymorphous low-grade neuroepithelial tumor of the young. A key inconsistency appeared between a pilocytic astrocytoma MC and a glioneuronal tumor PD. Two high-grade astrocytomas were misclassified as pleomorphic xanthoastrocytomas. Additionally, low variant allelic frequency in gangliogliomas likely contributed to misclassifications as control in 5 cases. This study emphasized the importance of integrating DMP with PD in diagnosing pediatric glial and glioneuronal tumors with BRAF mutations. Although DMP offers significant diagnostic insights, its limitations, particularly in cases with low tumor content, necessitate cautious interpretation, as well as its use as a complementary diagnostic tool, rather than a definitive method.

Opportunities and Challenges of Utilising Big Data on SATUSEHAT Platform in Nursing: A Literature Review

The SATUSEHAT platform which is Indonesia Health Services (IHS) is a form of digital transformation initiated by the Indonesian Ministry of Health. This platform integrates the health data of all Indonesian people including medical records across health facilities which will develop into a national health data center and has the opportunity to become big health data for the Government. To face this, the nursing field must prepare for various opportunities and challenges. Objective: To provide an overview of the opportunities and challenges of utilizing big data through the SATUSEHAT platform in the nursing field. The method used in this research is literature review. The keywords used were Big data in nursing and The Application of big data for the future. Literature searches were conducted using the online database method starting from 2015-2022 through ScienceDirect, ProQuest and Clinical Key. As a result of the literature review with a case study design, it was found that opportunities for big data utilization include personalized care, nursing research development, data-based policy formulation, while challenges include increasing data processing and management competencies, integrating big data education curriculum, privacy and ethical issues and standardizing nursing terminology Recommendations It is hoped that further research can discuss the preparations that must be made to maximize the potential for big data utilization in the future.

Yearly Update of the List of Plant Diseases in Korea (6.2 Edition, 2024)

Since 2009, the Korean Society of Plant Pathology has established the Committee on Common Names of Plant Disease to systematically review and determine plant disease names and related terminologies. The committee published the 6th edition of the List of Plant Diseases in Korea (LPDK) in 2022, and the list has been made publicly accessible online. The online database has significantly enhanced user accessibility, expedited update processes, and improved interoperability with other databases. As a result, the 6.1 edition of the list was released by online LPDK in 2023, detailing new disease names added over the preceding year and revisions to existing names. Subsequently, in 2024, the 6.2 edition was published, encompassing 6,765 diseases caused by 2,503 pathogen taxa across 1,432 host species. The public release of the online database has, however, introduced several challenges and tasks. Addressing these issues necessitates the development of modern, standardized nomenclature guidelines and a robust system for the registration of new disease names. Open communication and collaboration among the diverse members of the Korean Society of Plant Pathology are required to ensure the reliability of the LPDK.

Challenges and Benefits of a Multidisciplinary Approach to Treatment in Clinical Medicine

Introduction: The multidisciplinary approach in healthcare unites professionals from different fields to deliver patient-centered care. This collaborative team, comprising care partners, hospitalists, nurses, pharmacists, and others, operates with shared goals, leveraging electronic records, regular assessments, and patient involvement. Objective: In this review, we aim to investigate the challenges and benefits of a multidisciplinary approach to treatment in clinical medicine. Methodology: In our study, we included English studies from online databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library using the following keywords “delusions”, “pharmacotherapy”, “psychotherapy”, and “antipsychotics” till January 2024. Results: The result of the search using our search strategy was 2367 articles. We screened these articles to choose the articles related to our topic. We did a full-text screening of 344 articles after excluding the remaining articles by title and abstract screening. Finally, we used 50 articles to gather information about our topic and write this review. Scientific Novelty: Lies in its integration of diverse expertise, methodologies, and perspectives to address complex healthcare challenges. Practical Significance of the Results Obtained: Its practical significance lies in improving patient outcomes, optimizing resource utilization, and fostering innovation through collaborative problem-solving and evidence-based practices. Conclusion: This literature review focused on the multidisciplinary approach in medicine to ensure quality healthcare for patients. Stressing the advantages such as decreasing negative patient outcomes and increasing treatment strategies by collaboration among health care professionals.

Challenges and Benefits of a Multidisciplinary Approach to Treatment in Clinical Medicine

Introduction: The multidisciplinary approach in healthcare unites professionals from different fields to deliver patient-centered care. This collaborative team, comprising care partners, hospitalists, nurses, pharmacists, and others, operates with shared goals, leveraging electronic records, regular assessments, and patient involvement. Objective: In this review, we aim to investigate the challenges and benefits of a multidisciplinary approach to treatment in clinical medicine. Methodology: In our study, we included English studies from online databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library using the following keywords “delusions”, “pharmacotherapy”, “psychotherapy”, and “antipsychotics” till January 2024. Results: The result of the search using our search strategy was 2367 articles. We screened these articles to choose the articles related to our topic. We did a full-text screening of 344 articles after excluding the remaining articles by title and abstract screening. Finally, we used 50 articles to gather information about our topic and write this review. Scientific Novelty: Lies in its integration of diverse expertise, methodologies, and perspectives to address complex healthcare challenges. Practical Significance of the Results Obtained: Its practical significance lies in improving patient outcomes, optimizing resource utilization, and fostering innovation through collaborative problem-solving and evidence-based practices. Conclusion: This literature review focused on the multidisciplinary approach in medicine to ensure quality healthcare for patients. Stressing the advantages such as decreasing negative patient outcomes and increasing treatment strategies by collaboration among health care professionals.

Acrylic Resin Denture Base Material Enhancement by Fiber, Filler, and Nano Filler Addition: A Systematic Review

Background: In the current study, two wt. concentrations of strontium titanate (SrTiO3) Nano powder (1% and 1.5% wt.) were added. An evaluation was conducted on some properties of heat-cured Acrylic Resin. Aim: to investigate how introducing SrTiO3 (NPs) Nanoparticles in amounts of 1% weight and 1.5% weight impacted some of the mechanical and physical properties of heat-cured denture base material and describe the results of adding (Strontium Titanate Nanoparticles) to Heat Cure Acrylic Denture Base Material. Materials and methods: An Electronic Systematic Review was conducted in different databases: (Science Direct, PubMed, Web of Science, and Google Scholar searches) were consulted on this topic, as well as on a hand search of the scientific literature. Published writings from 2015 to 2022 were obtained, examined, and relevant articles were chosen for this review. The online databases were used to perform a literature search for publications published until 2022, without any date or language restrictions. The overview highlights the most significant developments in this field, demonstrating how resin technology developed in many ways. Results: Acrylic Resins' Mechanical and Biological Qualities have been enhanced through the surface modification of poly (methyl methacrylate), the addition of Natural or Mineral Fibers, Fillers, including Nano fillers, and/or Fillers. The post-polymerizations activity decreased the quantity of leftover monomer. New Varieties of Acrylic resins were created for the processing of computer-aided design/computer-aided manufacturing systems and three-dimensional printing. The findings suggest that current knowledge is to use acrylic resin in different cases of dentistry with SrTiO3 NPs and acrylic resin. that consider the most esthetic material and more comfortable, good Strength and Resistance to Wear. Conclusions: that addition of SrTiO3 Nanoparticles into denture base acrylic material improves transverse Strength, Surface Hardness Values, and Glass Transition Temperature, with a Negligible decrease in Surface Roughness.

Nutrient dataset development via FAO/INFOODS approach for infant nutritional survey in rural Matiari, Pakistan

To accurately evaluate dietary intake, multiple resources are necessary, including serving-size modules, pictures, and questionnaires that are used to gather information during surveys. One critical component is the accessibility of food composition data at the national or regional level, which is required to determine dietary intake. Food Agriculture Organization/International Network of Food Data Systems (FAO/INFOODs) tools are useful for developing high-quality food composition data. We used these tools to create a nutrient dataset for a nutritional survey in Matiari, Sindh, and to collect dietary information through a 24-hour food recall questionnaire. The survey results indicated 540 distinct types of foods, including 291 ready-to-eat items, 84 foods used as ingredients in recipes, and 164 various composite and mixed recipes. Most food items corresponded to the national and regional Food Composition Tables (FCTs) and the Food and Nutrient Database for Dietary Studies (FNDDS) of the USDA, with the exception of recipe food data. We utilized Eurofir-recipe calculation methods to compute the recipe data. The data were homogenized and standardized utilizing EFSA and Langual™. Because of the obsolescence and inadequacy of Pakistan's food composition table in assessing essential nutrients, we had to source data from various other sources. Consequently, to establish the nutrient dataset, we incorporated approximately 25 % of user data from national sources, with recipe data comprising 46 % and less than 20 % extracted from regional, U.S database, and diverse online sources. This study is the first effort in which we gathered data from reliable sources representing local eating patterns, with some exceptions. Future studies will hugely benefit from this database, especially as we face a high prevalence of undernutrition in our part of the world.

CELIAC DISEASE: NEW POSSIBILITIES FOR DIAGNOSIS AND MANAGEMENT

Вackground. Celiac disease is an autoimmune disease that occurs in genetically predisposed individuals and is characterized by damage to the mucous membrane of the small intestine due to exposure to gluten. The interest of researchers in gluten-associated diseases is growing every year. The true prevalence of celiac disease is not sufficiently studied due to the rarity of "classic" cases and the higher frequency of atypical and various clinical manifestations of this disease. Manifestation of celiac disease is possible at any age, the disease is more often diagnosed in adults. All this dictates the need to develop new algorithms for examining patients for timely detection and treatment of сеliacia. Aim: To review updated key consensus documents on the diagnosis and treatment of celiac disease. Matherials and methods. The results of scientific research related to celiac disease were searched. The studies that are included were selected based on searches in the online databases PubMed, Web of Science, Scopus, Google Scholar and others and relate to the basic methods of diagnosis and management of celiac disease. 110 sources were selected for analysis, of which were used that met the search criteria. Results. Based on the analysis of experimental and clinical studies, difficulties were identified in diagnosing celiac disease associated with a greater prevalence of extraintestinal manifestations and a rarity of "classical" cases. Methods of approach to the diagnosis of celiac disease in children and adults have been developed, taking into account invasiveness and accessibility. The basic approach in the treatment of celiac disease is a observed gluten-free diet. Regarding the selection of products, the individual characteristics of each patient are taken into account. Conclusion. To verify the diagnosis, adults and children with suspected celiac disease are recommended to perform esophagogastroduodenoscopy with biopsy of the duodenal mucosa at several points. An alternative method of diagnosis can be a combination of a very high level of antibodies of the imonoglobulin (Ig) A class to tissue transglutaminase (TGAs) and positive antibodies to endomysium (anti EMA) in two blood samples, however, no single analysis is 100% specific for celiac disease, and the diagnostic accuracy varies significantly between different laboratories. The only proven effective treatment for celiac disease is a lifelong gluten-free diet. In the absence of a complete clinical and serological response to diet, treatment goals are determined individually for each patient. The development of new treatments for celiac disease continues.

Playing Board Games to Increase Emotional Competencies in School-Age Children and Older People: A Systematic Review

Board games have always been a part of our lives. Most studies highlight their potential for learning in childhood and for maintaining cognitive functions in older people. Nevertheless, regarding the benefits in childhood and older people and the social nature of board games, few studies have investigated the emotional nature of these shared play sessions. Thus, we conducted a systematic review of the scientific literature between 2011 and 2024 to identify the benefits of playing board games for both school-age children and older people in terms of emotional competence. First, we collected 1995 articles with defined keywords from online databases. Then, 11 articles were selected. For older people, most studies reported the usefulness of board games for emotional competencies, especially regarding depression, social interactions and communication. In childhood, board games were found to be an interesting tool for emotional competencies, helping reduce problem behaviors, support pro-social behaviors and emotion-related discussion.

Untargeted Metabolomics of the Sea Cucumber, Bohadschia marmorata (Jaeger, 1833)

The marine invertebrates such as sea cucumber are regarded as sources of diverse bioactive compounds with promising health and nutritional benefits. Many commercially traded sea cucumber species have been explored, yet none of the local low-value types in the province of La Union, Philippines. This study aimed to establish a baseline metabolomic profile of Bohadschia marmorata (Jaeger, 1833). The identification of compounds in its body wall utilized an Orbitrap MS-based approach. Metabolites were annotated using Compound Discover 3.2, and similarity searches were performed from online databases. Eleven putatively identified compounds, which included saponin (3beta,5xi,9xi)-28-Hydroxy-28-oxoolean-12-en-3-yl-beta-Dgalac topyranosyl-(1-3)-[beta-D-glucopyranosyl-(1-2)]-beta-D-glucopyranosiduronic acid, fatty acids and their byproducts such as eicosanoid (11,12-Epoxy-(5Z,8Z,11Z)-icosatrienoic acid) and prostanoids (13,14-dihydro Prostaglandin F1?; 13,14-Dihydro-15-keto Prostaglandin A2), dicarboxylic acids (tetradecanedioic acid; dodecanedioic acid; suberic acid; NP-001596), and amino acid (4-Oxoproline). The metabolic profile of the B. marmorata body wall showed a diverse group of representative metabolites common among holothurians associated with innate defense mechanisms, structural composition, and products of metabolic pathways. There is, however, a need to further isolate these compounds using other methods and test their biological activities.

Playing Board Games to Increase Emotional Competencies in School-Age Children and Older People: A Systematic Review

Board games have always been a part of our lives. Most studies highlight their potential for learning in childhood and for maintaining cognitive functions in older people. Nevertheless, regarding the benefits in childhood and older people and the social nature of board games, few studies have investigated the emotional nature of these shared play sessions. Thus, we conducted a systematic review of the scientific literature between 2011 and 2024 to identify the benefits of playing board games for both school-age children and older people in terms of emotional competence. First, we collected 1995 articles with defined keywords from online databases. Then, 11 articles were selected. For older people, most studies reported the usefulness of board games for emotional competencies, especially regarding depression, social interactions and communication. In childhood, board games were found to be an interesting tool for emotional competencies, helping reduce problem behaviors, support pro-social behaviors and emotion-related discussion.

Alternative Treatments for Emotional Experiencing and Processing in People with Migraine or Tension-Type Headache: A Scoping Review.

This narrative review aims to summarize the use of alternative treatments (e.g., relaxation training, meditation, written intervention) for emotional expression, processing, control, or management in patients with migraine and tension-type headaches, which the previous literature has shown to be related to migraine pain perception and headache symptoms. Online databases including PubMed, Scopus, Web of Science, PsycINFO, and Medline were searched to identify studies published between 2000 and 2023. A descriptive synthesis of the included studies was conducted. We included seven articles after screening 1.173 records. A total of 610 patients with a diagnosis of migraine or tension-type headache, and an average age of 19-45.5 years (68-90.4% females) were recruited in the selected studies. Overall, the results show that alternative approaches to headache treatment contribute to the management, reduction, or control of negative emotions and at the same time have a positive impact on pain perception and headache symptoms. However, in some cases, the effects are more promising than others, depending on the peculiarities or limitations of each approach considered. This review provides useful insights from a methodological point of view for future studies on the management or control of negative emotions in patients with migraine and tension-type headache.