Ongoing Extension Study Research Articles

Review Article: Second-generation thrombopoietin agents for treatment of chronic idiopathic thrombocytopenic purpura in adults

To review the pharmacology, pharmacokinetics, efficacy, and safety of two new thrombopoietic (TPO) receptor agonists, romiplostim and eltrombopag, in the treatment of chronic idiopathic thrombocytopenic purpura (ITP) in adults. A MEDLINE search was conducted (1966 to March 2009) using the search terms romiplostim, AMG 531, eltrombopag, SB-497115, idiopathic thrombocytopenic purpura. Articles on phases 1-3 clinical trials in patients with ITP were identified and reviewed. References from manufacturer information, and abstracts from recent hematology meetings, were also evaluated. Controlled clinical trials evaluating romiplostim and eltrombopag for treatment of chronic ITP in adults were selected from the data sources. All published relevant abstracts were also included. Limited randomized controlled trials and open-label ongoing long-term extension studies for romiplostim and eltrombopag, have shown that both TPO agonists are effective in improving the platelet count and reducing the bleeding episodes in adult patients with ITP unresponsive to at least one standard treatment. The most common adverse events associated with the drugs are mild to moderate headaches. The use of these agents has also been associated with rare but serious side-effects including bone marrow reticulin fibrosis, thrombotic events, and myeloid malignancies. Until more long-term follow-up data regarding the safety, as well as comparative studies that further define the role of TPO agonists versus other agents in the treatment of chronic ITP are available, these agents should be reserved for patients with ITP refractory or intolerant to standard therapy.

THE ORIGIN OF THE INFRARED EMISSION IN RADIO GALAXIES. II. ANALYSIS OF MID- TO FAR-INFRAREDSPITZEROBSERVATIONS OF THE 2JY SAMPLE

We present an analysis of deep mid- to far-infrared (MFIR) Spitzer photometric observations of the southern 2Jy sample of powerful radio sources (0.05 < z < 0.7), conducting a statistical investigation of the links between radio jet, AGN, starburst activity and MFIR properties. This is part of an ongoing extensive study of powerful radio galaxies that benefits from both complete optical emission line information and a uniquely high detection rate in the far-infrared (far-IR). We find tight correlations between the MFIR and [OIII] emission luminosities, which are significantly better than those between MFIR and extended radio luminosities, or between radio and [OIII] luminosities. Since [OIII] is a known indicator of intrinsic AGN power, these correlations confirm AGN illumination of the circum-nuclear dust as the primary heating mechanism for the dust producing thermal MFIR emission at both 24 and 70 microns. We demonstrate that AGN heating is energetically feasible, and identify the narrow line region clouds as the most likely location of the cool, far-IR emitting dust. Starbursts make a major contribution to the heating of the cool dust in only 15-28% of our targets. We also investigate the orientation dependence of the continuum properties, finding that the broad- and narrow-line objects in our sample with strong emission lines have similar distributions of MFIR luminosities and colours. Therefore our results are entirely consistent with the orientation-based unified schemes for powerful radio galaxies. However, the weak line radio galaxies (WLRG) form a separate class of objects with intrinsically low luminosity AGN in which both the optical emission lines and the MFIR continuum are weak.

Analysis of Allele Distribution for Six Short Tandem Repeat Loci in the French Canadian Population of Québec

Short tandem repeat (STR) loci represent a rich source of highly polymorphic markers in the human genome which are useful for the purposes of forensic identification and determination of biological relatedness of individuals. Here, as a part of an ongoing extensive study, we report the analysis of a multilocus genotype survey of 642 to 870 chromosomes in the French Canadian Caucasian population of Québec at six STR loci. The loci HUMCSF1PO, HUMTPOX, HUMTH01, HUMF13A01, HUMFESFPS, and HUMvWA were typed using two multiplex polymerase chain reactions (PCR). Amplified DNA samples were subsequently analyzed by polyacrylamide gel electrophoresis followed by silver staining. The heterozygote frequencies of the loci range from 0.614 to 0.820 (0.661 to 0.818 expected) and the number of alleles from 7 to 12 per locus. Although statistically significant deviation from Hardy-Weinberg expectations of genotype frequencies was noted at some loci by one or more tests, in general, the genotype frequencies are well estimated from the product of allele frequencies at all loci. The most frequent six-locus genotype is expected to occur in the French Canadian population with a frequency of 3.50 by 10(-5) and together, these six loci have an average probability of discrimination of 0.9999985. The study presented here indicates that these six STR loci are informative genetic markers for identity testing purposes in the French Canadian Caucasian population of Québec.