One-pot Synthesis Of Benzoxazoles Research Articles

One-Pot Synthesis of Benzoxazoles: A Promising Approach to Aromatic Heterocyclic Compounds Preparation

One-Pot Synthesis of Benzoxazoles: A Promising Approach to Aromatic Heterocyclic Compounds Preparation

One-Pot Synthesis of Benzoxazoles with Copper Nanoparticles

One-Pot Synthesis of Benzoxazoles with Copper Nanoparticles

A Novel Ionic Liquid Based on Imidazolium Cation as an Efficient and Reusable Catalyst for the One‐pot Synthesis of Benzoxazoles, Benzthiazoles, Benzimidazoles and 2‐Arylsubstituted Benzimidazoles

AbstractA novel dicationic ionic liquid based on imidazolium cation is designed, synthesized and successfully used as catalyst for the one‐pot synthesis of benzoxazoles, benzthiazoles, benzimidazoles and 2‐arylsubstituted benzimidazoles. The remarkable feature of this new catalyst is its ethyleneoxy bridge which participates in dissolving organic compound in ionic liquid. The application of this ionic liquid is studied in a new one‐pot method for synthesis of heterocyclic compounds under solvent‐free conditions. Simple and convenient procedure, high conversion, reusability of catalyst, easy purification and shorter reaction time are the advantageous features of this method.

One-pot synthesis of benzoxazoles via the metal-free ortho-C–H functionalization of phenols with nitroalkanes

PPA-activated nitroalkanes are employed in the design of a one-pot cascade transformation involvingortho-C–H functionalization, by Beckman rearrangement, and condensation to produce benzoxazoles and benzobisoxazoles directly from phenols.

Extending the scope of chromium-manganese redox-coupled reactions: a one-pot synthesis of benzoxazoles.

A critically important strategy for synthetic chemistry is the development of "domino" processes: those capable of concatenating multiple transformations into a single step. Such transformations not only provide an increase in synthetic efficiency, but also imply the development of a significant degree of mechanistic understanding. We report herein a new domino reaction, in which a chromium-manganese redox couple is employed both to catalytically reduce an o-hydroxy nitroarene and to oxidatively cyclize a subsequently formed imine. We find that the reaction is most effective for starting o-hydroxy nitroarenes with a strongly electron-withdrawing group at the para position.