The Noether symmetry and the conserved quantity of a fractional Birkhoffian system are studied within the Riemann—Liouville fractional derivatives. Firstly, the fractional Birkhoff's equations and the corresponding transversality conditions are given. Secondly, from special to general forms, Noether's theorems of a standard Birkhoffian system are given, which provide an approach and theoretical basis for the further research on the Noether symmetry of the fractional Birkhoffian system. Thirdly, the invariances of the fractional Pfaffian action under a special one-parameter group of infinitesimal transformations without transforming the time and a general one-parameter group of infinitesimal transformations with transforming the time are studied, respectively, and the corresponding Noether's theorems are established. Finally, an example is given to illustrate the application of the results.