Guanzhong Segment of Wei River was studied in this article. Based on water quality observational data (ammonia-nitrogen) and hydrology observational data (flow of the sections) of Guanzhong Segment of Wei River in the rainy, normal and wet season in 2006, improved one-dimensional steady-state river water quality model was calibrated. River water quality was predicted in the normal season which were compared with the observational data in 2005. The results show that the water quality computed by improved one-dimensional steady-state river water quality model is grossly consistent with the observational water quality data and the model may provide the technical supports for the response relationships of water quality and water quantity of Guanzhong Segment of Wei River.