Ongoing Proliferation Research Articles

Noninvasive Imaging of Immune Cell Activity in Myocardial Infarction Phases Using 99mTc-HYNIC-mAbKv1.3 SPECT/CT.

Acute myocardial infarction (MI) remains a leading cause of mortality worldwide, with inflammatory and reparative phases playing critical roles in disease progression. Currently, there is a pressing need for in vivo imaging techniques to monitor immune cell infiltration and inflammation activity during these phases. We developed a novel probe, 99mTc-HYNIC-mAbKv1.3, utilizing a monoclonal antibody that targets the voltage-gated potassium channel 1.3 (Kv1.3). This probe enables in vivo visualization of immune cells that express high levels of Kv1.3 proteins. In a murine MI model, SPECT/CT imaging with 99mTc-HYNIC-mAbKv1.3 demonstrated specific uptake in an infarcted myocardium during the inflammatory phase, reflecting immune cell infiltration and activity. During the reparative phase, the probe exhibited prolonged retention in the infarcted area, suggestive of ongoing immune cell proliferation. Immunofluorescence staining confirmed the probe's specificity. Biodistribution analysis indicated preferential accumulation in the infarcted myocardium and liver, consistent with SPECT/CT findings. Combined with [18F]FDG PET/CT, these modalities provided comprehensive insights into myocardial viability and inflammation. This study highlights the potential of 99mTc-HYNIC-mAbKv1.3 SPECT/CT as a noninvasive tool to monitor immune cell activity in different phases of MI, guide therapeutic interventions, and predict disease progression. Further translational studies are warranted to explore its clinical applicability in cardiac pathologies.

International Legal Governance of Space Resources and the Role of National Frameworks: The Case of China

Abstract Following decades long political and legal uncertainty, several space-faring States passed national laws asserting (or reaffirming) private rights on resources extracted in space. This “bottom-up” approach is now shaping the fundamentals of international norms and rules. While the so-called “Artemis Bloc” and the US legislative and policy-making efforts have been examined extensively, what is missing is an in-depth analysis of the stance and response of other major space-faring nations. This article contributes to the scholarship by studying China’s perspective. The article considers the ongoing proliferation of national laws and policy-making efforts and the increased pace of commercialisation in the space sector as the driving force of international law-making. It then notes the absence of a clear-cut national legislation in China governing space operations linked to resource extraction from celestial bodies. The paper argues that China, as a major space-faring and a developing country, is poised to have an assertive voice in international space law-making. It shows how a stronger national legal framework, coupled with international law and policy-making efforts, can elevate China’s contribution in international space law—in particular regarding space resource extraction and utilisation.

Bordering and status-harms

ABSTRACT This paper examines how everyday practices of ‘bordering’, as conceived by Yuval- Davis, Wemyss, and Cassidy (2019) as the ongoing proliferation of border sites where migrants are assessed to be fit for inclusion or exclusion, may violate moral respect by subjecting migrants to a wide array of discriminatory treatment, leading to what I call ‘status-harms’. Section II begins by providing an overview of bordering and the various forms it has taken, such as internal immigration checkpoints or even online visa application processes. Section III develops an account of comparative and non-comparative status-harms and why they constitute violations of moral respect. There, I pay special attention to comparative status-harms by proposing three conditions under which a comparative status-harm can be said to have occurred: (a) if an individual or group is singled out for disadvantageous treatment that others are not subjected to on the basis of a socially salient attribute, (b) if the attribute marks them out as inferior relative to those who are not affected thus, and (c) ascriptions of inferior status occur within a morally objectionable social hierarchy where they are targeted by hostile norms and practices centred around that attribute. I then consider how discriminatory practices of bordering routinely imposes status-harms on migrants. Section IV draws a distinction between two types of discrimination that migrants may be subjected to at border sites, which I term policy-based discrimination and procedure-based discrimination, and explores their relationship to the comparative and non-comparative status-harms suffered by migrants. I conclude in Section V.

Does the job performance of academics’ influence burnout and psychological counselling? A comparative analysis amongst high-, average-, low-, and non-performers

BackgroundExtensive research has been conducted treating burnout as an independent variable and performance as a dependent variable to proffer possible solutions to burnout and job performance among academics. Despite this, the burnout crises persist and are exacerbated by the ongoing global proliferation of higher education. Acknowledging this, the current study explored whether performance may contribute to the emergence of burnout.MethodsThe study’s sample population comprised 689 academics from Jiangsu province, China. Key Performance Indicator (KPI) results served to measure performance. Psychological counselling and Burnout were calculated using mental health results garnered from the universities. Data was collected on respondents' demographic characteristics and work situations. The mean scores were 0.517 (SD = 0.5) for gender and 1.586 (SD = 1.103) for age. The relationship among performance, job burnout, and psychological counselling was analysed via a cross-sectional survey deploying grouped regression.ResultsAcademics’ job performance was found to regulate their burnout (β = -0.058, P < 0.01). Higher performance of academics was significantly associated with lower job burnout and psychological counselling. Furthermore, psychological counselling significantly moderated job burnout (β = -0.012, P < 0.05) among academics without regulating their job performance.ConclusionThe paper supplements the discourse on job burnout and academic performance by suggesting a pre-counselling measure as a strategy to address the crises of burnout. The paper argued that the continued competence of employees should prevent burnout in Higher education and ensure better job performance.

Equity in Digital Health: Assessing Access and Utilization of Remote Patient Monitoring, Medical Apps, and Wearables in Underserved Communities.

This study examined access to, and use of remote patient monitoring (RPM), medical applications, and wearables in a racially diverse, lower-income population. Data were obtained via a cross-sectional survey of adults from low-income communities in Houston, Los Angeles, and New York between April and August 2023. The survey examined access to, and use of RPM, medical applications, and wearables, among respondents. Binary responses to the following questions were examined using logistic regression models: In the past 12 months, have you (i) used RPM, (ii) used a medical app, and (iii) used an electronic wearable device to monitor or track health or activity? A total of 305 surveys were returned, of which 212 were complete (69.5% completion rate). Demographically, 22% self-identified as Hispanic, 41% as non-Hispanic Black individuals, and 33% as non-Hispanic White individuals. Overall, 69% of respondents reported a pre-tax annual household income of less than $35 000 and 96% indicated they own a smart phone. However, only 3 of 10 reported using RPM, 15% reported using a medical app, and 14% reported using wearables. Race was strongly associated with RPM usage, with Black respondents significantly less likely to have used RPM, compared to their white counterparts (OR: 0.31, P = .002). Education (bachelor's degree or more OR: 4.79, P = .03) and higher income ($35 001 + OR: 4.68, P = .008) were strongly associated with medical app usage. In the wearables model, the same trend was observed with education (bachelor's degree or more OR: 4.45, P = .04), and higher income ($35 001 + OR: 5.49, P = .01). Compared to earlier studies that have reported utilization rates of between 50% and 60%, our finding of much lower utilization in economically disadvantaged populations that are at greater risks for sub-optimal health outcomes gives cause for greater concern. Considering the ongoing proliferation of digital health technological modalities, this further highlights the need to explore and address equity-based barriers to these health tools.

The impact of bionic prostheses on users' self-perceptions: A qualitative study

Bionic devices for reestablishing or augmenting users' capabilities (e.g., bionic prostheses or exoskeletons) are becoming increasingly common. While prior research examined how such devices affect others' perceptions of their users, little is known about how these devices affect users' self-image and -perception, and the corresponding theory is scarce. To account for this gap, we conducted semi-structured interviews with users of bionic upper limb prostheses to obtain insights into their self- and meta-perceptions. Results of our qualitative analysis indicate that using bionic prostheses influences the social (self-) perception of bionics users in multiple ways, such that users describe themselves as being seen as more competent by others and treated differently after receiving the bionic prosthesis in comparison to simpler models. Results imply a somewhat complex dual identity among users in the sense that the bionic device instills competence, but disability-related feelings of stigma are present simultaneously. Despite being exploratory, our findings thus indicate that using bionic devices affects users' self-perception, stereotypes, and interpersonal perceptions. The ongoing proliferation of restoring devices and the introduction of augmenting technologies in future work contexts, for example, might thus have unintended social consequences that need to be accounted for.

Extensive Independent Amplification of Platy-1 Retroposons in Tamarins, Genus Saguinus.

Platy-1 retroposons are short interspersed elements (SINEs) unique to platyrrhine primates. Discovered in the common marmoset (Callithrix jacchus) genome in 2016, these 100 bp mobile element insertions (MEIs) appeared to be novel drivers of platyrrhine evolution, with over 2200 full-length members across 62 different subfamilies, and strong evidence of ongoing proliferation in C. jacchus. Subsequent characterization of Platy-1 elements in Aotus, Saimiri and Cebus genera, suggested that the widespread mobilization detected in marmoset (family Callithrichidae) was perhaps an anomaly. Two additional Callithrichidae genomes are now available, a scaffold level genome assembly for Saguinus imperator (tamarin; SagImp_v1) and a chromosome-level assembly for Saguinus midas (Midas tamarin; ASM2_v1). Here, we report that each tamarin genome contains over 11,000 full-length Platy-1 insertions, about 1150 are shared by both Saguinus tamarins, 7511 are unique to S. imperator, and another 8187 are unique to S. midas. Roughly 325 are shared among the three callithrichids. We identified six new Platy-1 subfamilies derived from Platy-1-8, with the youngest new subfamily, Platy-1-8c_Saguinus, being the primary source of the Saguinus amplification burst. This constitutes the largest expansion of Platy-1 MEIs reported to date and the most extensive independent SINE amplification between two closely related species.

Debunking fake ad claims: the moderating role of gender

Countering ads with fake claims represent a significant challenge for marketers and policymakers. We show how gender can help better target debunking efforts toward fake ads. First, we find that females (vs. males) show higher sensitivity to debunking efforts toward fake ads, leading to less favorable attitudes toward the brand and, consequently, lower purchase intentions. We then further probe these effects by introducing processing variables from the tenets of perceived risk (perceived health risk) and information processing confidence (skepticism toward the ad). We find that debunking information induces higher levels of skepticism among females owing to their lower information processing confidence than males, leading to downstream effects of higher perceptions of health risk, less favorable attitudes toward the brand, and lower purchase intentions among females than males. Our findings provide implications for advertisers and policymakers to battle the ongoing proliferation of fake ads.

Editorial Special Section on “Power Quality in the Energy Transition: Selected Papers From ICHQP 2022”

Electrical power quality is a vital aspect when designing or assessing the operation of all modern power systems and forms an important part of the ongoing energy transition to more efficient and multi-vector systems. However, the ongoing proliferation and changing functionality of power electronic devices, coupled with new grid operating paradigms, such as renewable energy sources integration, microgrids, low-voltage dc distribution networks, and the large-scale integration of electric vehicles, present unique opportunities and challenges for grid operators the world over and require new assessment methods and fresh perspectives on the role of power quality.

Corpus compilation for digital humanities in lower– resourced languages: A practical look at compiling thematic digital media corpora in Serbian, Croatian and Slovenian

The digital era has unlocked unprecedented possibilities of compiling corpora of social discourse, which has brought corpus linguistic methods into closer interaction with other methods of discourse analysis and the humanities. Even when not using any specific techniques of corpus linguistics, drawing on some sort of corpus is increasingly resorted to for empirically–grounded social–scientific analysis (sometimes dubbed ‘corpus–assisted discourse analysis’ or ‘corpus–based critical discourse analysis’, cf. Hardt–Mautner 1995; Baker 2016). In the post–Yugoslav space, recent corpus developments have brought table–turning advantages in many areas of discourse research, along with an ongoing proliferation of corpora and tools. Still, for linguists and discourse analysts who embark on collecting specialized corpora for their own research purposes, many questions persist – partly due to the fast–changing background of these issues, but also due to the fact that there is still a gap in the corpus method, and in guidelines for corpus compilation, when applied beyond the anglophone contexts. In this paper we aim to discuss some possible solutions to these difficulties, by presenting one step–by–step account of a corpus building procedure specifically for Croatian, Serbian and Slovenian, through an example of compiling a thematic corpus from digital media sources (news articles and reader comments). Following an overview of corpus types, uses and advantages in social sciences and digital humanities, we present the corpus compilation possibilities in the South Slavic language contexts, including data scraping options, permissions and ethical issues, the factors that facilitate or complicate automated collection, and corpus annotation and processing possibilities. The study shows expanding possibilities for work with the given languages, but also some persistently grey areas where researchers need to make decisions based on research expectations. Overall, the paper aims to recapitulate our own corpus compilation experience in the wider context of South–Slavic corpus linguistics and corpus linguistic approaches in the humanities more generally

Acceptance and commitment therapy and its unacknowledged influences: Some old wine in a new bottle?

Recently, Goldfried suggested that one main reason for the underdevelopment of psychotherapy as a scientific enterprise was the lack of acknowledgment of past contributions. In this article, this issue is illustrated by analysing the particular case of acceptance and commitment therapy (ACT). ACT has clear overlaps with therapies from the systemic tradition, such as strategic therapy in the line of the Mental Research Institute in Palo Alto and with the more recent models of solution-focused therapy and narrative therapy. This article analyses theoretical overlaps with these models (e.g. the paradoxical nature of human problems and the nature of language) as well as examples of similarities in therapeutic strategies (externalization and the miracle question). It concludes by suggesting that this practice of inadvertently obliterating the past does not favour the development of the field or the creation of consensus but rather contributes to the ongoing proliferation of 'new' psychotherapy models. Trends that may contribute to circumventing this problem are discussed.

Responding to “Fake News”: Journalistic Perceptions of and Reactions to a Delegitimising Force

The “fake news” phenomenon has permeated academic scholarship and popular debate since the 2016 US presidential election. Much has been written on the circulation of “fake news” and other forms of mis- and disinformation online. Despite its ongoing proliferation, less effort has been made to better understand the work of those engaged in daily news production—journalists themselves. Funded by the Australian Research Council project Journalism Beyond the Crisis, this study investigates how journalists perceive and respond to this phenomenon at a time when the industry has come under significant attack, and trust in news media has fallen globally. To do so, it draws on in-depth interviews with journalists in Australia and the UK, providing topical insights on their perceptions of and reactions to this profoundly delegitimising force. While on one hand, our findings show journalists expressing significant concern about the rise of “fake news,” they also proactively seek—and, in some cases, implement—deliberate counterstrategies to defend their profession. These strategies range from discursive means—such as stressing and re-asserting journalists’ professional authority and legitimacy—to tangible measures at an organisational level, including newsroom diversity and increased transparency in the news production process.

Digital Print Stock Design: A Framework for the Post-Film Era

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">For most of cinema history, the defining factor in the post-production “look” of captured imagery was the print stock. In addition to serving the technical function of transforming scene-referred imagery for display, print stocks were engineered to impart preferential color characteristics and selected by filmmakers based on these qualities. As the physical medium of the print stock has been retired from image mastering workflows, so too has the principle of a global creative transform. This is neither necessary nor beneficial. With the ongoing proliferation of camera and display standards, unifying the imagery of a given piece of content has become increasingly challenging. This has led to the development of systems that address the technical aspects of the challenge, most notably the Academy Color Encoding System (ACES). Such initiatives and their broad adoption demonstrate an industry-wide recognition that world-class color grading demands world-class engineering. Yet, in spite of this recognition, there exists no initiative aimed at supporting the creative aspects of unifying motion imagery at the macro-level. This article outlines the proposed framework for the design of digital print stocks (DPSs), composed of a set of manipulations whose parameters can be intuitively modified by artists, resulting in a global look that can be deployed within any imaging pipeline</i> .

Durability of and role of AKT in FGF7p urothelial protection against cyclophosphamide.

We previously identified a peptide derived from human fibroblast growth factor 7 (FGF7p) that blocks urothelial apoptosis similar to full‐length FGF7, although effects of FGF7p on urothelial repair are unknown. Also, while urothelial AKT activation downstream of FGF7p correlated with the anti‐apoptotic effects, we have not directly interrogated the role of AKT in mediating the cytoprotection. Our goal was to assess effects of FGF7p on urothelial repair and the role of AKT signaling in mediating the cytoprotective effects of FGF7p. We performed hematoxylin and eosin (H&E), TUNEL, and/or immunofluorescence (IF) staining for various markers in FGF7p‐treated mice 28 days after giving cyclophosphamide or after co‐administering a systemic AKT antagonist with FGF7p 24 h after cyclophosphamide. Vehicle‐treated and injured mice had hyperplastic urothelium, incomplete return of mature superficial cell markers, ongoing proliferation, and continued presence of basal progenitor markers 28 days after injury; conversely, FGF7p‐treated mice had normal numbers of urothelial cell layers, nearly complete return of superficial cell markers, limited proliferation and fewer basal progenitor cells 28 days post‐injury. Vehicle‐treated mice also had ectopic lumenal basal progenitor cell markers, while FGF7p had none 28 days after cyclophosphamide. Co‐administration of an AKT inhibitor largely abrogated FGF7p‐driven AKT activation and cytoprotection in urothelium 24 h after injury. Thus, FGF7p drives faster and higher fidelity urothelial repair by limiting apoptotic injury via AKT signaling, similar to full‐length FGF7. Finally, FGF7p is much less expensive to synthesize and has a longer shelf life and higher purity than FGF7.

Inspiring imagination – embarrassing analogies: coping with the causes of cytoplasmic streaming

ABSTRACT In the late eighteenth and early nineteenth centuries, the observation of a phenomenon that we call today cyclosis or cytoplasmic streaming provoked great astonishment, and also raised great expectations of being able to penetrate into the secrets of living matter. From the outset, the steady circling flow of liquids and granules inside the cells of algae posed an explanatory challenge, because it seemed to contradict the laws of physics. With scarce epistemic support at hand, researchers adopted a series of analogies to give plausibility to their conclusions. None of these enjoyed lasting success. On the contrary, over the years, we can observe an ongoing proliferation of explanations, and a diversification of alleged mechanisms and agents. Moreover, all the adduced analogies were severely criticized by scientific contemporaries; several were even subjected to derision. Nevertheless, it seemed that nobody could do without them. This paper will focus on the period 1774–1840, and will analyze the contributions and analogical arguments of some prominent microscopists of the time, among them Bonaventura Corti, Charles Bonnet, Ludolph Christian Treviranus, Carl Heinrich Schultz-Schultzenstein, Giovanni Battista Amici, Henri Dutrochet, and Franz Meyen.

Genome Replication Is Associated With Release of Immunogenic DNA Waste

Innate DNA sensors detect foreign and endogenous DNA to induce responses to infection and cellular stress or damage. Inappropriate activation by self-DNA triggers severe autoinflammatory conditions, including Aicardi-Goutières syndrome (AGS) that can be caused by defects of the cytosolic DNase 3’repair exonuclease 1 (TREX1). TREX1 loss-of-function alleles are also associated with systemic lupus erythematosus (SLE). Chronic activation of innate antiviral immunity in TREX1-deficient cells depends on the DNA sensor cGAS, implying that accumulating TREX1 DNA substrates cause the inflammatory pathology. Retrotransposon-derived cDNAs were shown to activate cGAS in TREX1-deficient neuronal cells. We addressed other endogenous sources of cGAS ligands in cells lacking TREX1. We find that induced loss of TREX1 in primary cells induces a rapid IFN response that requires ongoing proliferation. The inflammatory phenotype of Trex1-/- mice was partially rescued by additional knock out of exonuclease 1, a multifunctional enzyme providing 5’ flap endonuclease activity for Okazaki fragment processing and postreplicative ribonucleotide excision repair. Our data imply genome replication as a source of DNA waste with pathogenic potential that is efficiently degraded by TREX1.

Multilateralism and public support for drone strikes

The use of armed drones has emerged as a principal counterterrorism tool for western militaries, especially France and the United States. While France submits its strikes to the United Nations for approval, the United States typically does not. Does this difference matter for public support and perceptions of legitimacy? To better understand these dynamics, we fielded original survey experiments across nationally representative samples in France and the United States totaling in over 1800 respondents. Our results reflect that international approval is associated with both higher public support and greater perceived legitimacy for a strike. Further, we find that respondents emphasize international law as the basis for support and legitimacy, suggesting a cross-national belief in multilateralism for normative rather than strictly instrumental reasons. These relationships are moderated by the identity of the country conducting a hypothetical strike, implying both an “othering” effect and the emergence of distinct models of strikes across countries that deserve more study amid the ongoing proliferation of armed drones. Video Abstract: https://www.youtube.com/watch?v=YevyaKThae0

Introduction: Island Narratives of Persistence and Resistance

This introduction to our special issue “Island Narratives of Persistence and Resistance” focuses on the ongoing proliferation of neocolonial, neoimperial and neoliberal constructions of the island in western and continental texts and discourses. It discusses the double and paradoxical logic of the island trope – which simultaneously suggests confinement and freedom, isolation and connection, over- and underdevelopment, inclusion and exclusion – and the evident material effects that these persistent figurations continue to have on the lives of islanders. It then places the focus on the mechanisms of resistance to these island narratives as exemplified in a range of fiction and non-fiction works from or about various island locations: Singapore, Vanuatu, Samoa, Nauru, Manus Island, the Bahamas, St Lucia, New Zealand, Staten Island, and the island continent of Australia. The essays engage with recognizable tropes and uses of the island: islands of exception and offshores, treasure and trash islands, island fortresses and militarized zones, fantasy and tourist islands.

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells.

The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers1-7. However, little is known about the long-term potential and clonal stability of the infused cells. Here we studied long-lasting CD19-redirected chimeric antigen receptor (CAR) T cells in two patients with chronic lymphocytic leukaemia1-4 who achieved a complete remission in 2010. CAR T cells remained detectable more than ten years after infusion, with sustained remission in both patients. Notably, a highly activated CD4+ population emerged in both patients, dominating the CAR T cell population at the later time points. This transition was reflected in the stabilization of the clonal make-up of CAR T cells with a repertoire dominated by a small number of clones. Single-cell profiling demonstrated that these long-persisting CD4+ CAR T cells exhibited cytotoxic characteristics along with ongoing functional activation and proliferation. In addition, longitudinal profiling revealed a population of gamma delta CAR T cells that prominently expanded in one patient concomitant with CD8+ CAR T cells during the initial response phase. Our identification and characterization of these unexpected CAR T cell populations provide novel insight into the CAR T cell characteristics associated with anti-cancer response and long-term remission in leukaemia.

Aims and criteria for advancing technology management research at the Journal of Operations Management

Aims and criteria for advancing technology management research at the <scp>Journal of Operations Management</scp>