Oligometastatic Status Research Articles

Evaluating the Utility of Local Therapy for Oligometastatic Lung Cancer

SUMMARY In patients with metastatic non-small-cell lung cancer, limited metastases are identified as ‘oligometastases’, and such patients are expected to be long-term progression-free, or possibly curable by local control of those lesions. Especially for oligometastatic recurrence after complete resection of the original primary tumor, local treatment should be taken into consideration as a choice of treatment. Oligoprogression after the administration of EGF receptor tyrosine kinase inhibitors for EGFR-mutated non-small-cell lung cancer might also be indicated for local treatment while continuing the EGF receptor tyrosine kinase inhibitor treatment. Since stereotactic radiotherapy delivery is now available, its potential for local control is nearly comparable to that of surgery. These two major modalities of local therapy should be selected for the treatment of oligometastases after carefully considering both the oligometastatic status (organs, number) and patient status.

Thermal ablation techniques: a curative treatment of bone metastases in selected patients?

Thermal ablation techniques (radiofrequency-ablation/cryotherapy) can be indicated with a curative intent. The success rate and prognostic factors for complete treatment were analysed. The medical records of all patients who had undergone curatively intended thermal ablation of bone metastases between September 2001 and February 2012 were retrospectively analysed. The goal was to achieve complete treatment of all bone metastases in patients with oligometastatic disease (group 1) or only of bone metastases that could potentially lead to skeletal-related events in patients with a long life expectancy (group 2). We report the rate of complete treatment according to patient characteristics, primary tumour site, bone metastasis characteristics, radiofrequency ablation/cryotherapy and the treatment group (group 1/group 2). Eighty-nine consecutive patients had undergone curatively intended thermal ablation of 122 bone metastases. The median follow-up was 22.8 months [IQR = 12.2-44.4]. In the intent-to-treat analysis, the 1-year complete treatment rate was 67% (95%CI: 50%-76%). In the multivariate analysis the favourable prognostic factors for complete local treatment were oligometastatic status (p = 0.02), metachronous (p = 0.004) and small-sized (p = 0.001) bone metastases, without cortical bone erosion (p = 0.01) or neurological structures in the vicinity (p = 0.002). Thermal ablation should be included in the therapeutic arsenal for the cure of bone metastases. • Thermal ablation techniques are currently performed to palliate pain caused by bone metastases. • In selected patients, thermal ablation can also be indicated with a curative intent. • Oligometastatic and/or metachronous diseases are good prognostic factors for local success. • Small-size (<2 cm) bone metastases and no cortical erosion are good prognostic factors.