Aquasomes are considered an excellent and efficient carrier system for the transport of drugs or biochemically active long chain macromolecules such as proteins and peptides, various hormones, antigens, enzymes, and genes in the recently burgeoning field of nanobiotechnology research. These are three-layer self-collecting structures composed of an oligomeric film covering a strong stage nanocrystalline centre to which biochemically dynamic particles adhere to, independent of changes in the environment and which self-assembles through non-covalent or ionic connections. Aquasomes are circular particles, 60–300 nm in size, that are used to deliver antigens and medications. The structural stability is provided by the solid core, while the active drug molecules are stabilized and protected from dehydration by the polyhydroxy oligomer covering. The most common way to distribute aquasome formulations is parenterally, however recent research indicates that there may be additional, oral, ways as well. A combination of targeted molecular shielding and prolonged release mechanism is used by aquasome to deliver their bioactive chemicals. The present paper offers an overview of the aquasome as a potentially useful medication delivery technique. It covers every facet of aquasome, such as their structure, the processes for preparing them, ways to characterize them, and medical uses as a drug delivery system.