Context: India at present is experiencing a phenomenal increase in the number of older adults. Old age is marked by challenges across multiple domains of life. To overcome the challenges of old age, the focus should be on improving the quality of life (QOL) and meaning in life (MIL) of older adults. Aim: This study aimed to determine the effect of leisure activity on QOL and MIL of male and female older adults in old-age homes. Methodology: A cross-sectional study was conducted among 120 male and female retired older adults (65–80 years), living in old-age homes of Hooghly district, West Bengal, using the Older People's Quality of Life Questionnaire (OPQOL-35) by Bowling and Meaning in Life Questionnaire (MLQ) by Steger, Frazier, Oishi, & Kaler. Results: Older adults who engaged in active leisure activities had higher QOL and MIL than those engaged in passive leisure activities. Male older adults had higher QOL and MIL than female older adults. Conclusion: Opportunities to pursue active leisure activities should be promoted among older adults in old-age homes.